Parental occupational exposures in wood-related jobs and risk of testicular germ cell tumours in offspring in NORD-TEST a registry-based case–control study in Finland, Norway, and Sweden
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Parental occupational exposures in wood-related jobs and risk of testicular germ cell tumours in offspring in NORD-TEST a registry-based case–control study in Finland, Norway, and Sweden. / Corbin, Sara; Togawa, Kayo; Schüz, Joachim; Le Cornet, Charlotte; Fervers, Beatrice; Feychting, Maria; Wiebert, Pernilla; Hansen, Johnni; Dalton, Susanne Oksbjerg; Kjærheim, Kristina; Nordby, Karl Christian; Østrem, Ragnhild Strand; Skakkebæk, Niels E.; Uuksulainen, Sanni; Pukkala, Eero; Olsson, Ann.
In: International Archives of Occupational and Environmental Health, Vol. 95, 2022, p. 1243–1253.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Parental occupational exposures in wood-related jobs and risk of testicular germ cell tumours in offspring in NORD-TEST a registry-based case–control study in Finland, Norway, and Sweden
AU - Corbin, Sara
AU - Togawa, Kayo
AU - Schüz, Joachim
AU - Le Cornet, Charlotte
AU - Fervers, Beatrice
AU - Feychting, Maria
AU - Wiebert, Pernilla
AU - Hansen, Johnni
AU - Dalton, Susanne Oksbjerg
AU - Kjærheim, Kristina
AU - Nordby, Karl Christian
AU - Østrem, Ragnhild Strand
AU - Skakkebæk, Niels E.
AU - Uuksulainen, Sanni
AU - Pukkala, Eero
AU - Olsson, Ann
N1 - Publisher Copyright: © 2021, The Author(s).
PY - 2022
Y1 - 2022
N2 - Objective: We assessed the association between parental prenatal exposures in wood-related jobs and risk of testicular germ cell tumours (TGCT) in offspring. Methods: NORD-TEST, a registry-based case–control study in Sweden, Finland and Norway, included 8112 TGCT cases diagnosed at ages 14–49 years between 1978 and 2012 with no history of prior cancer, and up to four controls matched to each case on year and country of birth. Parents of cases and controls were identified via linkages with the population registries and their occupational information was retrieved from censuses. The Nordic Occupational Cancer Study Job-Exposure Matrix was used to assign occupational exposures to each parent. Logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results: Maternal wood-related job was not associated with the risk of TGCT in offspring (OR 1.08, CI 0.55–2.14), while paternal wood-related job was associated with a decreased risk of TGCT in offspring (OR 0.85, CI 0.75–0.96). None of the specific wood-related jobs, such as upholsterers, sawyers, or construction carpenters, were significantly associated with a risk of TGCT. Only exception was observed in a sensitivity analysis which showed an increased risk in the small group of sons of fathers working as ‘cabinetmakers and joiners’ the year before conception (OR of 2.06, CI 1.00–4.25). Conclusion: This large-scale NORD-TEST analysis provided no evidence of an association between parental prenatal exposures in wood-related jobs and TGCT in sons.
AB - Objective: We assessed the association between parental prenatal exposures in wood-related jobs and risk of testicular germ cell tumours (TGCT) in offspring. Methods: NORD-TEST, a registry-based case–control study in Sweden, Finland and Norway, included 8112 TGCT cases diagnosed at ages 14–49 years between 1978 and 2012 with no history of prior cancer, and up to four controls matched to each case on year and country of birth. Parents of cases and controls were identified via linkages with the population registries and their occupational information was retrieved from censuses. The Nordic Occupational Cancer Study Job-Exposure Matrix was used to assign occupational exposures to each parent. Logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results: Maternal wood-related job was not associated with the risk of TGCT in offspring (OR 1.08, CI 0.55–2.14), while paternal wood-related job was associated with a decreased risk of TGCT in offspring (OR 0.85, CI 0.75–0.96). None of the specific wood-related jobs, such as upholsterers, sawyers, or construction carpenters, were significantly associated with a risk of TGCT. Only exception was observed in a sensitivity analysis which showed an increased risk in the small group of sons of fathers working as ‘cabinetmakers and joiners’ the year before conception (OR of 2.06, CI 1.00–4.25). Conclusion: This large-scale NORD-TEST analysis provided no evidence of an association between parental prenatal exposures in wood-related jobs and TGCT in sons.
KW - Nordic countries
KW - Occupational exposure
KW - Prenatal exposure delayed effects
KW - Testicular germ cell tumours
KW - Testicular neoplasms
KW - Wood-related jobs
U2 - 10.1007/s00420-021-01818-4
DO - 10.1007/s00420-021-01818-4
M3 - Journal article
C2 - 34853884
AN - SCOPUS:85120373291
VL - 95
SP - 1243
EP - 1253
JO - International Archives of Occupational and Environmental Health
JF - International Archives of Occupational and Environmental Health
SN - 0340-0131
ER -
ID: 306895842