Personal Care Product Use in Men and Urinary Concentrations of Select Phthalate Metabolites and Parabens: Results from the Environment And Reproductive Health (EARTH) Study
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Personal Care Product Use in Men and Urinary Concentrations of Select Phthalate Metabolites and Parabens : Results from the Environment And Reproductive Health (EARTH) Study. / Nassan, Feiby L; Coull, Brent A; Gaskins, Audrey J; Williams, Michelle A; Skakkebaek, Niels E; Ford, Jennifer B; Ye, Xiaoyun; Calafat, Antonia M; Braun, Joseph M; Hauser, Russ.
In: Environmental Health Perspectives, Vol. 125, No. 8, 087012, 2017.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Personal Care Product Use in Men and Urinary Concentrations of Select Phthalate Metabolites and Parabens
T2 - Results from the Environment And Reproductive Health (EARTH) Study
AU - Nassan, Feiby L
AU - Coull, Brent A
AU - Gaskins, Audrey J
AU - Williams, Michelle A
AU - Skakkebaek, Niels E
AU - Ford, Jennifer B
AU - Ye, Xiaoyun
AU - Calafat, Antonia M
AU - Braun, Joseph M
AU - Hauser, Russ
PY - 2017
Y1 - 2017
N2 - BACKGROUND: Personal care products (PCPs) are exposure sources to phthalates and parabens; however, their contribution to men's exposure is understudied.OBJECTIVES: We examined the association between PCP use and urinary concentrations of phthalate metabolites and parabens in men.METHODS: In a prospective cohort, at multiple study visits, men self-reported their use of 14 PCPs and provided a urine sample (2004-2015, Boston, MA). We measured urinary concentrations of 9 phthalate metabolites and methylparaben, propylparaben, and butylparaben. We estimated the covariate-adjusted percent change in urinary concentrations associated with PCP use using linear mixed and Tobit mixed regressions. We also estimated weights for each PCP in a weighted binary score regression and modeled the resulting composite weighted PCP use.RESULTS: Four hundred men contributed 1,037 urine samples (mean of 3/man). The largest percent increase in monoethyl phthalate (MEP) was associated with use of cologne/perfume (83%, p-value<0.01) and deodorant (74%, p-value<0.01). In contrast, the largest percent increase for parabens was associated with the use of suntan/sunblock lotion (66-156%) and hand/body lotion (79-147%). Increases in MEP and parabens were generally greater with PCP use within 6 h of urine collection. A subset of 10 PCPs that were used within 6 h of urine collection contributed to at least 70% of the weighted score and predicted a 254-1,333% increase in MEP and parabens concentrations. Associations between PCP use and concentrations of the other phthalate metabolites were not statistically significant.CONCLUSIONS: We identified 10 PCPs of relevance and demonstrated that their use within 6 h of urine collection strongly predicted MEP and paraben urinary concentrations. https://doi.org/10.1289/EHP1374.
AB - BACKGROUND: Personal care products (PCPs) are exposure sources to phthalates and parabens; however, their contribution to men's exposure is understudied.OBJECTIVES: We examined the association between PCP use and urinary concentrations of phthalate metabolites and parabens in men.METHODS: In a prospective cohort, at multiple study visits, men self-reported their use of 14 PCPs and provided a urine sample (2004-2015, Boston, MA). We measured urinary concentrations of 9 phthalate metabolites and methylparaben, propylparaben, and butylparaben. We estimated the covariate-adjusted percent change in urinary concentrations associated with PCP use using linear mixed and Tobit mixed regressions. We also estimated weights for each PCP in a weighted binary score regression and modeled the resulting composite weighted PCP use.RESULTS: Four hundred men contributed 1,037 urine samples (mean of 3/man). The largest percent increase in monoethyl phthalate (MEP) was associated with use of cologne/perfume (83%, p-value<0.01) and deodorant (74%, p-value<0.01). In contrast, the largest percent increase for parabens was associated with the use of suntan/sunblock lotion (66-156%) and hand/body lotion (79-147%). Increases in MEP and parabens were generally greater with PCP use within 6 h of urine collection. A subset of 10 PCPs that were used within 6 h of urine collection contributed to at least 70% of the weighted score and predicted a 254-1,333% increase in MEP and parabens concentrations. Associations between PCP use and concentrations of the other phthalate metabolites were not statistically significant.CONCLUSIONS: We identified 10 PCPs of relevance and demonstrated that their use within 6 h of urine collection strongly predicted MEP and paraben urinary concentrations. https://doi.org/10.1289/EHP1374.
KW - Adult
KW - Cosmetics
KW - Environmental Exposure/statistics & numerical data
KW - Hazardous Substances/urine
KW - Humans
KW - Male
KW - Parabens/metabolism
KW - Phthalic Acids/urine
U2 - 10.1289/EHP1374
DO - 10.1289/EHP1374
M3 - Journal article
C2 - 28886595
VL - 125
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
SN - 0091-6765
IS - 8
M1 - 087012
ER -
ID: 197346361