Reproductive Markers of Testicular Function and Size During Puberty in Boys With and Without a History of Cryptorchidism
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Reproductive Markers of Testicular Function and Size During Puberty in Boys With and Without a History of Cryptorchidism. / Rodprasert, Wiwat; Koskenniemi, Jaakko J; Virtanen, Helena E; Sadov, Sergey; Perheentupa, Antti; Ollila, Helena; Albrethsen, Jakob; Andersson, Anna-Maria; Juul, Anders; Skakkebaek, Niels E; Main, Katharina M; Toppari, Jorma.
In: The Journal of clinical endocrinology and metabolism, Vol. 107, No. 12, 2022, p. 3353-3361.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Reproductive Markers of Testicular Function and Size During Puberty in Boys With and Without a History of Cryptorchidism
AU - Rodprasert, Wiwat
AU - Koskenniemi, Jaakko J
AU - Virtanen, Helena E
AU - Sadov, Sergey
AU - Perheentupa, Antti
AU - Ollila, Helena
AU - Albrethsen, Jakob
AU - Andersson, Anna-Maria
AU - Juul, Anders
AU - Skakkebaek, Niels E
AU - Main, Katharina M
AU - Toppari, Jorma
N1 - © The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society.
PY - 2022
Y1 - 2022
N2 - CONTEXT: Longitudinal data on levels of hypothalamic-pituitary-gonadal axis hormones and insulin-like growth factor I (IGF-I) during puberty in boys with a history of cryptorchidism are largely missing.OBJECTIVE: We aimed to compare pubertal hormone levels between boys with a history of congenital cryptorchidism who experienced spontaneous testicular descent or underwent orchiopexy and boys without a history of cryptorchidism.METHODS: This was a nested case-control study within a population-based birth cohort, with a prospective, longitudinal pubertal follow-up every 6 months (2005 to 2019). Participants were 109 Finnish boys, including boys with a history of unilateral cryptorchidism who underwent orchiopexy (n = 15), unilateral cryptorchidism who had spontaneous testicular descent (n = 15), bilateral cryptorchidism who underwent orchiopexy (n = 9), bilateral cryptorchidism who had spontaneous testicular descent (n = 7), and controls (n = 63). Serum reproductive hormone levels and testicular volumes were measured.RESULTS: From around onset of puberty, boys with bilateral cryptorchidism who underwent orchiopexy had significantly higher follicle-stimulating hormone (FSH) and lower inhibin B levels than controls. Boys with unilateral cryptorchidism who underwent orchiopexy had significantly higher FSH than controls, whereas inhibin B levels were similar. Testosterone, luteinizing hormone, insulin-like factor 3, and IGF-I were generally similar between groups. Testicular volume of boys with unilateral or bilateral cryptorchidism who underwent orchiopexy was smaller than that of the controls from 1 year after pubertal onset (P < 0.05).CONCLUSION: Cryptorchid boys, particularly those with bilateral cryptorchidism who underwent orchiopexy, had altered levels of serum biomarkers of Sertoli cells and germ cells and smaller testicular volumes compared with controls.
AB - CONTEXT: Longitudinal data on levels of hypothalamic-pituitary-gonadal axis hormones and insulin-like growth factor I (IGF-I) during puberty in boys with a history of cryptorchidism are largely missing.OBJECTIVE: We aimed to compare pubertal hormone levels between boys with a history of congenital cryptorchidism who experienced spontaneous testicular descent or underwent orchiopexy and boys without a history of cryptorchidism.METHODS: This was a nested case-control study within a population-based birth cohort, with a prospective, longitudinal pubertal follow-up every 6 months (2005 to 2019). Participants were 109 Finnish boys, including boys with a history of unilateral cryptorchidism who underwent orchiopexy (n = 15), unilateral cryptorchidism who had spontaneous testicular descent (n = 15), bilateral cryptorchidism who underwent orchiopexy (n = 9), bilateral cryptorchidism who had spontaneous testicular descent (n = 7), and controls (n = 63). Serum reproductive hormone levels and testicular volumes were measured.RESULTS: From around onset of puberty, boys with bilateral cryptorchidism who underwent orchiopexy had significantly higher follicle-stimulating hormone (FSH) and lower inhibin B levels than controls. Boys with unilateral cryptorchidism who underwent orchiopexy had significantly higher FSH than controls, whereas inhibin B levels were similar. Testosterone, luteinizing hormone, insulin-like factor 3, and IGF-I were generally similar between groups. Testicular volume of boys with unilateral or bilateral cryptorchidism who underwent orchiopexy was smaller than that of the controls from 1 year after pubertal onset (P < 0.05).CONCLUSION: Cryptorchid boys, particularly those with bilateral cryptorchidism who underwent orchiopexy, had altered levels of serum biomarkers of Sertoli cells and germ cells and smaller testicular volumes compared with controls.
KW - Male
KW - Humans
KW - Cryptorchidism
KW - Insulin-Like Growth Factor I
KW - Case-Control Studies
KW - Prospective Studies
KW - Inhibins
KW - Follicle Stimulating Hormone
KW - Testis/metabolism
KW - Puberty
KW - Biomarkers
U2 - 10.1210/clinem/dgac520
DO - 10.1210/clinem/dgac520
M3 - Journal article
C2 - 36073163
VL - 107
SP - 3353
EP - 3361
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 12
ER -
ID: 345015410