Testicular descent: INSL3, testosterone, genes and the intrauterine milieu

Research output: Contribution to journal › Journal article › Research

Standard

Testicular descent: INSL3, testosterone, genes and the intrauterine milieu. / Bay, Katrine; Main, Katharina M; Toppari, Jorma; Skakkebæk, Niels E; Medscape.

In: Nature Reviews. Urology, 15.03.2011.

Research output: Contribution to journal › Journal article › Research

Harvard

Bay, K, Main, KM, Toppari, J, Skakkebæk, NE & Medscape 2011, 'Testicular descent: INSL3, testosterone, genes and the intrauterine milieu', Nature Reviews. Urology. https://doi.org/10.1038/nrurol.2011.23, https://doi.org/10.1038/nrurol.2011.23

APA

Bay, K., Main, K. M., Toppari, J., Skakkebæk, N. E., & Medscape (2011). Testicular descent: INSL3, testosterone, genes and the intrauterine milieu. Nature Reviews. Urology. https://doi.org/10.1038/nrurol.2011.23, https://doi.org/10.1038/nrurol.2011.23

Vancouver

Bay K, Main KM, Toppari J, Skakkebæk NE, Medscape. Testicular descent: INSL3, testosterone, genes and the intrauterine milieu. Nature Reviews. Urology. 2011 Mar 15. https://doi.org/10.1038/nrurol.2011.23, https://doi.org/10.1038/nrurol.2011.23

Author

Bay, Katrine ; Main, Katharina M ; Toppari, Jorma ; Skakkebæk, Niels E ; Medscape. / Testicular descent: INSL3, testosterone, genes and the intrauterine milieu. In: Nature Reviews. Urology. 2011.

Bibtex

@article{4f895f04b19d4d11b47698b47865a868,
title = "Testicular descent: INSL3, testosterone, genes and the intrauterine milieu",
abstract = "Complete testicular descent is a sign of, and a prerequisite for, normal testicular function in adult life. The process of testis descent is dependent on gubernacular growth and reorganization, which is regulated by the Leydig cell hormones insulin-like peptide 3 (INSL3) and testosterone. Investigation of the role of INSL3 and its receptor, relaxin-family peptide receptor 2 (RXFP2), has contributed substantially to our understanding of the hormonal control of testicular descent. Cryptorchidism is a common congenital malformation, which is seen in 2-9% of newborn boys, and confers an increased risk of infertility and testicular cancer in adulthood. Although some cases of isolated cryptorchidism in humans can be ascribed to known genetic defects, such as mutations in INSL3 or RXFP2, the cause of cryptorchidism remains unknown in most patients. Several animal and human studies are currently underway to test the hypothesis that in utero factors, including environmental and maternal lifestyle factors, may be involved in the etiology of cryptorchidism. Overall, the etiology of isolated cryptorchidism seems to be complex and multifactorial, involving both genetic and nongenetic components.",
author = "Katrine Bay and Main, {Katharina M} and Jorma Toppari and Skakkeb{\ae}k, {Niels E} and Main, {Katharina Maria}",
year = "2011",
month = mar,
day = "15",
doi = "10.1038/nrurol.2011.23",
language = "English",
journal = "Nature Reviews. Urology",
issn = "1759-4812",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Testicular descent: INSL3, testosterone, genes and the intrauterine milieu

AU - Bay, Katrine

AU - Main, Katharina M

AU - Toppari, Jorma

AU - Skakkebæk, Niels E

AU - Medscape

PY - 2011/3/15

Y1 - 2011/3/15

N2 - Complete testicular descent is a sign of, and a prerequisite for, normal testicular function in adult life. The process of testis descent is dependent on gubernacular growth and reorganization, which is regulated by the Leydig cell hormones insulin-like peptide 3 (INSL3) and testosterone. Investigation of the role of INSL3 and its receptor, relaxin-family peptide receptor 2 (RXFP2), has contributed substantially to our understanding of the hormonal control of testicular descent. Cryptorchidism is a common congenital malformation, which is seen in 2-9% of newborn boys, and confers an increased risk of infertility and testicular cancer in adulthood. Although some cases of isolated cryptorchidism in humans can be ascribed to known genetic defects, such as mutations in INSL3 or RXFP2, the cause of cryptorchidism remains unknown in most patients. Several animal and human studies are currently underway to test the hypothesis that in utero factors, including environmental and maternal lifestyle factors, may be involved in the etiology of cryptorchidism. Overall, the etiology of isolated cryptorchidism seems to be complex and multifactorial, involving both genetic and nongenetic components.

AB - Complete testicular descent is a sign of, and a prerequisite for, normal testicular function in adult life. The process of testis descent is dependent on gubernacular growth and reorganization, which is regulated by the Leydig cell hormones insulin-like peptide 3 (INSL3) and testosterone. Investigation of the role of INSL3 and its receptor, relaxin-family peptide receptor 2 (RXFP2), has contributed substantially to our understanding of the hormonal control of testicular descent. Cryptorchidism is a common congenital malformation, which is seen in 2-9% of newborn boys, and confers an increased risk of infertility and testicular cancer in adulthood. Although some cases of isolated cryptorchidism in humans can be ascribed to known genetic defects, such as mutations in INSL3 or RXFP2, the cause of cryptorchidism remains unknown in most patients. Several animal and human studies are currently underway to test the hypothesis that in utero factors, including environmental and maternal lifestyle factors, may be involved in the etiology of cryptorchidism. Overall, the etiology of isolated cryptorchidism seems to be complex and multifactorial, involving both genetic and nongenetic components.

U2 - 10.1038/nrurol.2011.23

DO - 10.1038/nrurol.2011.23

M3 - Journal article

C2 - 21403659

JO - Nature Reviews. Urology

JF - Nature Reviews. Urology

SN - 1759-4812

ER -

ID: 34138353