Urinary phthalate excretion in 555 healthy Danish boys with and without pubertal gynaecomastia
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Urinary phthalate excretion in 555 healthy Danish boys with and without pubertal gynaecomastia. / Mieritz, Mikkel G; Frederiksen, Hanne; Sørensen, Kaspar; Aksglaede, Lise; Mouritsen, Annette; Hagen, Casper P; Skakkebaek, Niels E; Andersson, Anna-Maria; Juul, Anders.
In: International Journal of Andrology, Vol. 35, No. 3, 2012, p. 227-35.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Urinary phthalate excretion in 555 healthy Danish boys with and without pubertal gynaecomastia
AU - Mieritz, Mikkel G
AU - Frederiksen, Hanne
AU - Sørensen, Kaspar
AU - Aksglaede, Lise
AU - Mouritsen, Annette
AU - Hagen, Casper P
AU - Skakkebaek, Niels E
AU - Andersson, Anna-Maria
AU - Juul, Anders
N1 - © 2012 The Authors. International Journal of Andrology © 2012 European Academy of Andrology.
PY - 2012
Y1 - 2012
N2 - Pubertal gynaecomastia is a clinical sign of an oestrogen-androgen imbalance, which occurs in 40-60% of adolescent Caucasian boys. In most cases no underlying endocrinopathy can be identified. A recent study reports higher plasma phthalate levels in Turkish boys with pubertal gynaecomastia. Therefore, we asked whether there was an association between concurrent measures of urinary phthalate metabolites and pubertal timing as well as the presence of gynaecomastia in otherwise healthy boys. We studied a total of 555 healthy boys (age 6.07-19.83 years) as part of the COPENHAGEN Puberty Study. Anthropometry and pubertal stages (PH1-6 and G1-5) were evaluated, and the presence of gynaecomastia was assessed. Non-fasting blood samples were analysed for serum testosterone and morning urine samples were analysed for the total content of 12 phthalate metabolites (MEP, MnBP, MiBP, MBzP, MEHP, MEHHP, MEOHP, MECPP, MiNP, MHiNP, MiONP and MCiOP) by LC-MS/MS. A statistically significant negative correlation was observed between chronological age and the urinary concentration of the sum of measured metabolites DEHP (¿DEHPm) (r = -0.164) and DiNP (¿DiNPm) (r = -0.224), respectively, and the sum of monobutyl phthalate (MBP) isomers (¿MBP((i+n)) ) (r = -0.139) (all with p
AB - Pubertal gynaecomastia is a clinical sign of an oestrogen-androgen imbalance, which occurs in 40-60% of adolescent Caucasian boys. In most cases no underlying endocrinopathy can be identified. A recent study reports higher plasma phthalate levels in Turkish boys with pubertal gynaecomastia. Therefore, we asked whether there was an association between concurrent measures of urinary phthalate metabolites and pubertal timing as well as the presence of gynaecomastia in otherwise healthy boys. We studied a total of 555 healthy boys (age 6.07-19.83 years) as part of the COPENHAGEN Puberty Study. Anthropometry and pubertal stages (PH1-6 and G1-5) were evaluated, and the presence of gynaecomastia was assessed. Non-fasting blood samples were analysed for serum testosterone and morning urine samples were analysed for the total content of 12 phthalate metabolites (MEP, MnBP, MiBP, MBzP, MEHP, MEHHP, MEOHP, MECPP, MiNP, MHiNP, MiONP and MCiOP) by LC-MS/MS. A statistically significant negative correlation was observed between chronological age and the urinary concentration of the sum of measured metabolites DEHP (¿DEHPm) (r = -0.164) and DiNP (¿DiNPm) (r = -0.224), respectively, and the sum of monobutyl phthalate (MBP) isomers (¿MBP((i+n)) ) (r = -0.139) (all with p
U2 - 10.1111/j.1365-2605.2012.01279.x
DO - 10.1111/j.1365-2605.2012.01279.x
M3 - Journal article
C2 - 22612475
VL - 35
SP - 227
EP - 235
JO - International Journal of Andrology
JF - International Journal of Andrology
SN - 0105-6263
IS - 3
ER -
ID: 40167080