Copy Number Variants and Polygenic Risk Scores Predict Need of Care in Autism and/or ADHD Families
Research output: Contribution to journal › Journal article › Research › peer-review
Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are highly heritable neurodevelopmental disorders that frequently co-occur. Both rare and common genetic variants are important for ASD and ADHD risk but their combined contribution to clinical heterogeneity is unclear. In a sample of 39 ASD and/or ADHD families we estimated the overall variance explained by known rare copy number variants (CNVs) and polygenic risk score (PRS) from common variants to be 10% in comorbid ASD/ADHD, 4% in ASD and 2% in ADHD. We show that burden of large, rare CNVs and PRS is significantly higher in adult ASD and/or ADHD patients with sustained need for specialist care compared to their unaffected relatives, while affected relatives fall in-between the two.
Original language | English |
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Journal | Journal of Autism and Developmental Disorders |
Volume | 51 |
Issue number | 1 |
Pages (from-to) | 276-285 |
Number of pages | 10 |
ISSN | 0162-3257 |
DOIs | |
Publication status | Published - Jan 2021 |
- Adolescent, Adult, Attention Deficit Disorder with Hyperactivity/diagnosis, Autistic Disorder/diagnosis, Child, Comorbidity, DNA Copy Number Variations/genetics, Denmark/epidemiology, Female, Humans, Male, Multifactorial Inheritance/genetics, Predictive Value of Tests, Risk Factors
Research areas
ID: 288278431