Identification of women at high risk of postpartum psychiatric episodes

Identification of women at high risk of postpartum psychiatric episodes: A population-based study quantifying relative and absolute risks following exposure to selected risk factors and genetic liability

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Identification of women at high risk of postpartum psychiatric episodes : A population-based study quantifying relative and absolute risks following exposure to selected risk factors and genetic liability. / Johannsen, Benedicte M. W.; Larsen, Janne Tidselbak; Liu, Xiaoqin; Madsen, Kathrine Bang; Mægbæk, Merete Lund; Albiñana, Clara; Bergink, Veerle; Laursen, Thomas M.; Bech, Bodil H.; Mortensen, Preben Bo; Nordentoft, Merete; Børglum, Anders D.; Werge, Thomas; Hougaard, David M.; Agerbo, Esben; Petersen, Liselotte Vogdrup; Munk-Olsen, Trine.

In: Acta Psychiatrica Scandinavica, 23.10.2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Johannsen, BMW, Larsen, JT, Liu, X, Madsen, KB, Mægbæk, ML, Albiñana, C, Bergink, V, Laursen, TM, Bech, BH, Mortensen, PB, Nordentoft, M, Børglum, AD, Werge, T, Hougaard, DM, Agerbo, E, Petersen, LV & Munk-Olsen, T 2023, 'Identification of women at high risk of postpartum psychiatric episodes: A population-based study quantifying relative and absolute risks following exposure to selected risk factors and genetic liability', Acta Psychiatrica Scandinavica. https://doi.org/10.1111/acps.13622

APA

Johannsen, B. M. W., Larsen, J. T., Liu, X., Madsen, K. B., Mægbæk, M. L., Albiñana, C., Bergink, V., Laursen, T. M., Bech, B. H., Mortensen, P. B., Nordentoft, M., Børglum, A. D., Werge, T., Hougaard, D. M., Agerbo, E., Petersen, L. V., & Munk-Olsen, T. (2023). Identification of women at high risk of postpartum psychiatric episodes: A population-based study quantifying relative and absolute risks following exposure to selected risk factors and genetic liability. Acta Psychiatrica Scandinavica. https://doi.org/10.1111/acps.13622

Vancouver

Johannsen BMW, Larsen JT, Liu X, Madsen KB, Mægbæk ML, Albiñana C et al. Identification of women at high risk of postpartum psychiatric episodes: A population-based study quantifying relative and absolute risks following exposure to selected risk factors and genetic liability. Acta Psychiatrica Scandinavica. 2023 Oct 23. https://doi.org/10.1111/acps.13622

Author

Johannsen, Benedicte M. W. ; Larsen, Janne Tidselbak ; Liu, Xiaoqin ; Madsen, Kathrine Bang ; Mægbæk, Merete Lund ; Albiñana, Clara ; Bergink, Veerle ; Laursen, Thomas M. ; Bech, Bodil H. ; Mortensen, Preben Bo ; Nordentoft, Merete ; Børglum, Anders D. ; Werge, Thomas ; Hougaard, David M. ; Agerbo, Esben ; Petersen, Liselotte Vogdrup ; Munk-Olsen, Trine. / Identification of women at high risk of postpartum psychiatric episodes : A population-based study quantifying relative and absolute risks following exposure to selected risk factors and genetic liability. In: Acta Psychiatrica Scandinavica. 2023.

Bibtex

@article{6bf8fd3dfa8b4bb8bbb6c25ab567cdc7,

title = "Identification of women at high risk of postpartum psychiatric episodes: A population-based study quantifying relative and absolute risks following exposure to selected risk factors and genetic liability",

abstract = "Background: We quantified relative and absolute risks of postpartum psychiatric episodes (PPE) following risk factors: Young age, past personal or family history of psychiatric disorders, and genetic liability. Methods: We conducted a register-based study using the iPSYCH2012 case-cohort sample. Exposures were personal history of psychiatric episodes prior to childbirth, being a young mother (giving birth before the age of 21.5 years), having a family history of psychiatric disorders, and a high (highest quartile) polygenic score (PGS) for major depression. PPE was defined within 12 months postpartum by prescription of psychotropic medication or in- and outpatient contact to a psychiatric facility. We included primiparous women born 1981–1999, giving birth before January 1st, 2016. We conducted Cox regression to calculate hazard ratios (HRs) of PPE, absolute risks were calculated using cumulative incidence functions. Results: We included 8174 primiparous women, and the estimated baseline PPE risk was 6.9% (95% CI 6.0%–7.8%, number of PPE cases: 2169). For young mothers with a personal and family history of psychiatric disorders, the absolute risk of PPE was 21.6% (95% CI 15.9%–27.8%). Adding information on high genetic liability to depression, the risk increased to 29.2% (95% CI 21.3%–38.4%) for PPE. Conclusions: Information on prior personal and family psychiatric episodes as well as age may assist in estimating a personalized risk of PPE. Furthermore, additional information on genetic liability could add even further to this risk assessment.",

keywords = "epidemiology, perinatal mental health",

author = "Johannsen, {Benedicte M. W.} and Larsen, {Janne Tidselbak} and Xiaoqin Liu and Madsen, {Kathrine Bang} and M{\ae}gb{\ae}k, {Merete Lund} and Clara Albi{\~n}ana and Veerle Bergink and Laursen, {Thomas M.} and Bech, {Bodil H.} and Mortensen, {Preben Bo} and Merete Nordentoft and B{\o}rglum, {Anders D.} and Thomas Werge and Hougaard, {David M.} and Esben Agerbo and Petersen, {Liselotte Vogdrup} and Trine Munk-Olsen",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Acta Psychiatrica Scandinavica published by John Wiley & Sons Ltd.",

year = "2023",

month = oct,

day = "23",

doi = "10.1111/acps.13622",

language = "English",

journal = "Acta Psychiatrica Scandinavica",

issn = "0001-690X",

publisher = "Wiley",

}

RIS

TY - JOUR

T1 - Identification of women at high risk of postpartum psychiatric episodes

T2 - A population-based study quantifying relative and absolute risks following exposure to selected risk factors and genetic liability

AU - Johannsen, Benedicte M. W.

AU - Larsen, Janne Tidselbak

AU - Liu, Xiaoqin

AU - Madsen, Kathrine Bang

AU - Mægbæk, Merete Lund

AU - Albiñana, Clara

AU - Bergink, Veerle

AU - Laursen, Thomas M.

AU - Bech, Bodil H.

AU - Mortensen, Preben Bo

AU - Nordentoft, Merete

AU - Børglum, Anders D.

AU - Werge, Thomas

AU - Hougaard, David M.

AU - Agerbo, Esben

AU - Petersen, Liselotte Vogdrup

AU - Munk-Olsen, Trine

PY - 2023/10/23

Y1 - 2023/10/23

N2 - Background: We quantified relative and absolute risks of postpartum psychiatric episodes (PPE) following risk factors: Young age, past personal or family history of psychiatric disorders, and genetic liability. Methods: We conducted a register-based study using the iPSYCH2012 case-cohort sample. Exposures were personal history of psychiatric episodes prior to childbirth, being a young mother (giving birth before the age of 21.5 years), having a family history of psychiatric disorders, and a high (highest quartile) polygenic score (PGS) for major depression. PPE was defined within 12 months postpartum by prescription of psychotropic medication or in- and outpatient contact to a psychiatric facility. We included primiparous women born 1981–1999, giving birth before January 1st, 2016. We conducted Cox regression to calculate hazard ratios (HRs) of PPE, absolute risks were calculated using cumulative incidence functions. Results: We included 8174 primiparous women, and the estimated baseline PPE risk was 6.9% (95% CI 6.0%–7.8%, number of PPE cases: 2169). For young mothers with a personal and family history of psychiatric disorders, the absolute risk of PPE was 21.6% (95% CI 15.9%–27.8%). Adding information on high genetic liability to depression, the risk increased to 29.2% (95% CI 21.3%–38.4%) for PPE. Conclusions: Information on prior personal and family psychiatric episodes as well as age may assist in estimating a personalized risk of PPE. Furthermore, additional information on genetic liability could add even further to this risk assessment.

AB - Background: We quantified relative and absolute risks of postpartum psychiatric episodes (PPE) following risk factors: Young age, past personal or family history of psychiatric disorders, and genetic liability. Methods: We conducted a register-based study using the iPSYCH2012 case-cohort sample. Exposures were personal history of psychiatric episodes prior to childbirth, being a young mother (giving birth before the age of 21.5 years), having a family history of psychiatric disorders, and a high (highest quartile) polygenic score (PGS) for major depression. PPE was defined within 12 months postpartum by prescription of psychotropic medication or in- and outpatient contact to a psychiatric facility. We included primiparous women born 1981–1999, giving birth before January 1st, 2016. We conducted Cox regression to calculate hazard ratios (HRs) of PPE, absolute risks were calculated using cumulative incidence functions. Results: We included 8174 primiparous women, and the estimated baseline PPE risk was 6.9% (95% CI 6.0%–7.8%, number of PPE cases: 2169). For young mothers with a personal and family history of psychiatric disorders, the absolute risk of PPE was 21.6% (95% CI 15.9%–27.8%). Adding information on high genetic liability to depression, the risk increased to 29.2% (95% CI 21.3%–38.4%) for PPE. Conclusions: Information on prior personal and family psychiatric episodes as well as age may assist in estimating a personalized risk of PPE. Furthermore, additional information on genetic liability could add even further to this risk assessment.

KW - epidemiology

KW - perinatal mental health

U2 - 10.1111/acps.13622

DO - 10.1111/acps.13622

M3 - Journal article

C2 - 37871908

AN - SCOPUS:85174633399

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

SN - 0001-690X

ER -

ID: 371465996

Department of Clinical Medicine