Prognostic thresholds of FDG-PET SUVmean and SUVmax for survival and nodal involvement in lung neuroendocrine neoplasms
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Prognostic thresholds of FDG-PET SUVmean and SUVmax for survival and nodal involvement in lung neuroendocrine neoplasms. / Soldath, Patrick; Binderup, Tina; Kjaer, Andreas; Knigge, Ulrich; Langer, Seppo W; Petersen, René H.
In: European Journal of Cardio-thoracic Surgery, Vol. 65, No. 2, ezae030, 2024.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Prognostic thresholds of FDG-PET SUVmean and SUVmax for survival and nodal involvement in lung neuroendocrine neoplasms
AU - Soldath, Patrick
AU - Binderup, Tina
AU - Kjaer, Andreas
AU - Knigge, Ulrich
AU - Langer, Seppo W
AU - Petersen, René H.
N1 - © The Author(s) 2024. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.
PY - 2024
Y1 - 2024
N2 - OBJECTIVES: The mean and maximum standardized uptake values (SUVmean and SUVmax) on fluorine-18 fluorodeoxyglucose (FDG)-positron emission tomography (PET) are prognostic biomarkers for survival and nodal involvement in non-small cell lung cancer but their prognostic value in lung neuroendocrine neoplasms (NENs) remains unexplored. In this study, we aimed to examine whether they are also prognostic biomarkers for survival and nodal involvement in lung NENs.METHODS: We retrospectively studied patients with typical carcinoid, atypical carcinoid, or large cell neuroendocrine carcinoma who had been radically resected at our institution between 2008 and 2020. We measured SUVmean and SUVmax on all primary tumors and lymph nodes that were clinically and/or pathologically involved. We dichotomized the patients into groups of high or low SUVmean and SUVmax of the primary tumour using time-dependent receiver operating characteristic curves and compared their overall survival using Kaplan-Meier curves and Cox models. Lastly, we predicted the patients' pathological nodal status with SUVmean and SUVmax of the lymph nodes using binomial logistic models.RESULTS: The study included 245 patients. Patients died earlier if their SUVmean of the primary tumour exceeded 3.9 (HR 1.97, 95% CI 1.27-3.04, p = 0.002) or SUVmax exceeded 5.3 (HR 1.85, 95% CI 1.20-2.87, p = 0.006). Likewise, patients had a higher risk of pathological nodal involvement if their SUVmean of the lymph nodes exceeded 3.3 (OR 10.00, 95% CI 2.59-51.01, p = 0.002) or SUVmax exceeded 4.2 (OR 4.00, 95% CI 1.20-14.65, p = 0.028).CONCLUSIONS: The FDG-PET SUVmean and SUVmax are strong prognostic biomarkers for survival and nodal involvement in lung NENs and could be important guides for making treatment decisions.
AB - OBJECTIVES: The mean and maximum standardized uptake values (SUVmean and SUVmax) on fluorine-18 fluorodeoxyglucose (FDG)-positron emission tomography (PET) are prognostic biomarkers for survival and nodal involvement in non-small cell lung cancer but their prognostic value in lung neuroendocrine neoplasms (NENs) remains unexplored. In this study, we aimed to examine whether they are also prognostic biomarkers for survival and nodal involvement in lung NENs.METHODS: We retrospectively studied patients with typical carcinoid, atypical carcinoid, or large cell neuroendocrine carcinoma who had been radically resected at our institution between 2008 and 2020. We measured SUVmean and SUVmax on all primary tumors and lymph nodes that were clinically and/or pathologically involved. We dichotomized the patients into groups of high or low SUVmean and SUVmax of the primary tumour using time-dependent receiver operating characteristic curves and compared their overall survival using Kaplan-Meier curves and Cox models. Lastly, we predicted the patients' pathological nodal status with SUVmean and SUVmax of the lymph nodes using binomial logistic models.RESULTS: The study included 245 patients. Patients died earlier if their SUVmean of the primary tumour exceeded 3.9 (HR 1.97, 95% CI 1.27-3.04, p = 0.002) or SUVmax exceeded 5.3 (HR 1.85, 95% CI 1.20-2.87, p = 0.006). Likewise, patients had a higher risk of pathological nodal involvement if their SUVmean of the lymph nodes exceeded 3.3 (OR 10.00, 95% CI 2.59-51.01, p = 0.002) or SUVmax exceeded 4.2 (OR 4.00, 95% CI 1.20-14.65, p = 0.028).CONCLUSIONS: The FDG-PET SUVmean and SUVmax are strong prognostic biomarkers for survival and nodal involvement in lung NENs and could be important guides for making treatment decisions.
U2 - 10.1093/ejcts/ezae030
DO - 10.1093/ejcts/ezae030
M3 - Journal article
C2 - 38305412
VL - 65
JO - European Journal of Cardio-thoracic Surgery
JF - European Journal of Cardio-thoracic Surgery
SN - 1010-7940
IS - 2
M1 - ezae030
ER -
ID: 383212074