Ten-Year Trends of Clinicopathologic Features and Surgical Treatment of Lung Cancer in China
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Ten-Year Trends of Clinicopathologic Features and Surgical Treatment of Lung Cancer in China. / Zang, Ruochuan; Shi, Ju-Fang; Lerut, Toni E; Wang, Le; Liu, Chia-Chuan; Brunelli, Alessandro; Petersen, René Horsleben; Ng, Calvin Sze Hang; Lim, Eric; Gao, Shugeng; AME Thoracic Surgery Collaborative Group.
In: The Annals of Thoracic Surgery, Vol. 109, No. 2, 2020, p. 389-395.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Ten-Year Trends of Clinicopathologic Features and Surgical Treatment of Lung Cancer in China
AU - Zang, Ruochuan
AU - Shi, Ju-Fang
AU - Lerut, Toni E
AU - Wang, Le
AU - Liu, Chia-Chuan
AU - Brunelli, Alessandro
AU - Petersen, René Horsleben
AU - Ng, Calvin Sze Hang
AU - Lim, Eric
AU - Gao, Shugeng
AU - AME Thoracic Surgery Collaborative Group
N1 - Copyright © 2020 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
PY - 2020
Y1 - 2020
N2 - BACKGROUND: Lung cancer has changed significantly during the past 2 decades in its epidemiology and treatment. This retrospective analysis used data from 7 major areas of China over 10 years to evaluate clinicopathologic and surgical treatment trends of lung cancer in China during the past decade.METHODS: Data from 7184 patients with primary lung cancer who were treated between 2005 and 2014 in 8 provinces of China were retrospectively collected. Their clinicopathologic features and surgical treatment information were recorded. Simple linear regression models and the Cochrane-Armitage trend test were used to assess temporal trends.RESULTS: The proportion of female patients (from 57.4% to 59.6%; P < .001) and nonsmoking patients (from 37.1% to 48.9%; P < .001) and of patients with a family history of malignant tumors (from 7.0% to 11.5%; P < .001) increased significantly. The percentage of adenocarcinomas increased significantly (from 36.4% to 53.5%; P < .001), with a decrease in squamous cell carcinomas (from 45.4% to 34.4%; P < .001). After 2008, the application of minimally invasive surgery significantly increased in China (from 2.4% in 2008 to 34.4% in 2014; P < .001), with a decline in the rate of conversion to open operation (from 14.3% in 2008 to 4.8% in 2014; P = .146) and an increase in the proportion of systematic mediastinal lymph node dissection (from 50.0% in 2008 to 84.1% in 2014; P = .001).CONCLUSIONS: This study investigated recent 10-year trends in the clinicopathologic features and surgical treatment of lung cancer in China and found significant important changes. These findings provide valuable information and evidence for the future control of the disease in China.
AB - BACKGROUND: Lung cancer has changed significantly during the past 2 decades in its epidemiology and treatment. This retrospective analysis used data from 7 major areas of China over 10 years to evaluate clinicopathologic and surgical treatment trends of lung cancer in China during the past decade.METHODS: Data from 7184 patients with primary lung cancer who were treated between 2005 and 2014 in 8 provinces of China were retrospectively collected. Their clinicopathologic features and surgical treatment information were recorded. Simple linear regression models and the Cochrane-Armitage trend test were used to assess temporal trends.RESULTS: The proportion of female patients (from 57.4% to 59.6%; P < .001) and nonsmoking patients (from 37.1% to 48.9%; P < .001) and of patients with a family history of malignant tumors (from 7.0% to 11.5%; P < .001) increased significantly. The percentage of adenocarcinomas increased significantly (from 36.4% to 53.5%; P < .001), with a decrease in squamous cell carcinomas (from 45.4% to 34.4%; P < .001). After 2008, the application of minimally invasive surgery significantly increased in China (from 2.4% in 2008 to 34.4% in 2014; P < .001), with a decline in the rate of conversion to open operation (from 14.3% in 2008 to 4.8% in 2014; P = .146) and an increase in the proportion of systematic mediastinal lymph node dissection (from 50.0% in 2008 to 84.1% in 2014; P = .001).CONCLUSIONS: This study investigated recent 10-year trends in the clinicopathologic features and surgical treatment of lung cancer in China and found significant important changes. These findings provide valuable information and evidence for the future control of the disease in China.
KW - Adenocarcinoma/mortality
KW - Aged
KW - Aged, 80 and over
KW - Carcinoma, Squamous Cell/mortality
KW - China
KW - Cross-Sectional Studies
KW - Databases, Factual
KW - Disease-Free Survival
KW - Female
KW - Humans
KW - Linear Models
KW - Lung Neoplasms/mortality
KW - Lymphatic Metastasis
KW - Male
KW - Middle Aged
KW - Neoplasm Invasiveness/pathology
KW - Neoplasm Staging
KW - Pneumonectomy/methods
KW - Prognosis
KW - Retrospective Studies
KW - Risk Assessment
KW - Survival Analysis
KW - Thoracic Surgery, Video-Assisted/methods
KW - Treatment Outcome
U2 - 10.1016/j.athoracsur.2019.08.017
DO - 10.1016/j.athoracsur.2019.08.017
M3 - Journal article
C2 - 31526778
VL - 109
SP - 389
EP - 395
JO - The Annals of Thoracic Surgery
JF - The Annals of Thoracic Surgery
SN - 0003-4975
IS - 2
ER -
ID: 241943574