Biochemistry of the Endocrine Heart

Research output: Contribution to journal › Review › Research › peer-review

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Biochemistry of the Endocrine Heart. / Goetze, Jens P.; Bartels, Emil D.; Shalmi, Theodor W.; Andraud‐dang, Lilian; Rehfeld, Jens F.

In: Biology, Vol. 11, No. 7, 971, 2022.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Goetze, JP, Bartels, ED, Shalmi, TW, Andraud‐dang, L & Rehfeld, JF 2022, 'Biochemistry of the Endocrine Heart', Biology, vol. 11, no. 7, 971. https://doi.org/10.3390/biology11070971

APA

Goetze, J. P., Bartels, E. D., Shalmi, T. W., Andraud‐dang, L., & Rehfeld, J. F. (2022). Biochemistry of the Endocrine Heart. Biology, 11(7), [971]. https://doi.org/10.3390/biology11070971

Vancouver

Goetze JP, Bartels ED, Shalmi TW, Andraud‐dang L, Rehfeld JF. Biochemistry of the Endocrine Heart. Biology. 2022;11(7). 971. https://doi.org/10.3390/biology11070971

Author

Goetze, Jens P. ; Bartels, Emil D. ; Shalmi, Theodor W. ; Andraud‐dang, Lilian ; Rehfeld, Jens F. / Biochemistry of the Endocrine Heart. In: Biology. 2022 ; Vol. 11, No. 7.

Bibtex

@article{4afc05ec3203449a9e28c4c5dbb247cc,

title = "Biochemistry of the Endocrine Heart",

abstract = "Production and release of natriuretic peptides and other vasoactive peptides are tightly regulated in mammalian physiology and involved in cardiovascular homeostasis. As endocrine cells, the cardiac myocytes seem to possess almost all known chemical necessities for translation, post‐translational modifications, and complex peptide proteolysis. In several ways, intracellular granules in the cells contain not only peptides destined for secretion but also important granin molecules involved in maintaining a regulated secretory pathway. In this review, we will highlight the biochemical phenotype of the endocrine heart recapitulating that the cardiac myocytes are capable endocrine cells. Understanding the basal biochemistry of the endocrine heart in producing and se-creting peptides to circulation could lead to new discoveries concerning known peptide products as well as hitherto unidentified cardiac peptide products. In perspective, studies on natriuretic peptides in the heart have shown that the post‐translational phase of gene expression is not only rele-vant for human physiology but may prove implicated also in the development and, perhaps one day, cure of human cardiovascular disease.",

keywords = "ANP, BNP, cholecystokinin, CNP, natriuretic peptide, PAM",

author = "Goetze, {Jens P.} and Bartels, {Emil D.} and Shalmi, {Theodor W.} and Lilian Andraud‐dang and Rehfeld, {Jens F.}",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

doi = "10.3390/biology11070971",

language = "English",

volume = "11",

journal = "Biology",

issn = "2079-7737",

publisher = "MDPI AG",

number = "7",

}

RIS

TY - JOUR

T1 - Biochemistry of the Endocrine Heart

AU - Goetze, Jens P.

AU - Bartels, Emil D.

AU - Shalmi, Theodor W.

AU - Andraud‐dang, Lilian

AU - Rehfeld, Jens F.

PY - 2022

Y1 - 2022

N2 - Production and release of natriuretic peptides and other vasoactive peptides are tightly regulated in mammalian physiology and involved in cardiovascular homeostasis. As endocrine cells, the cardiac myocytes seem to possess almost all known chemical necessities for translation, post‐translational modifications, and complex peptide proteolysis. In several ways, intracellular granules in the cells contain not only peptides destined for secretion but also important granin molecules involved in maintaining a regulated secretory pathway. In this review, we will highlight the biochemical phenotype of the endocrine heart recapitulating that the cardiac myocytes are capable endocrine cells. Understanding the basal biochemistry of the endocrine heart in producing and se-creting peptides to circulation could lead to new discoveries concerning known peptide products as well as hitherto unidentified cardiac peptide products. In perspective, studies on natriuretic peptides in the heart have shown that the post‐translational phase of gene expression is not only rele-vant for human physiology but may prove implicated also in the development and, perhaps one day, cure of human cardiovascular disease.

AB - Production and release of natriuretic peptides and other vasoactive peptides are tightly regulated in mammalian physiology and involved in cardiovascular homeostasis. As endocrine cells, the cardiac myocytes seem to possess almost all known chemical necessities for translation, post‐translational modifications, and complex peptide proteolysis. In several ways, intracellular granules in the cells contain not only peptides destined for secretion but also important granin molecules involved in maintaining a regulated secretory pathway. In this review, we will highlight the biochemical phenotype of the endocrine heart recapitulating that the cardiac myocytes are capable endocrine cells. Understanding the basal biochemistry of the endocrine heart in producing and se-creting peptides to circulation could lead to new discoveries concerning known peptide products as well as hitherto unidentified cardiac peptide products. In perspective, studies on natriuretic peptides in the heart have shown that the post‐translational phase of gene expression is not only rele-vant for human physiology but may prove implicated also in the development and, perhaps one day, cure of human cardiovascular disease.

KW - ANP

KW - BNP

KW - cholecystokinin

KW - CNP

KW - natriuretic peptide

KW - PAM

U2 - 10.3390/biology11070971

DO - 10.3390/biology11070971

M3 - Review

C2 - 36101352

AN - SCOPUS:85133328984

VL - 11

JO - Biology

JF - Biology

SN - 2079-7737

IS - 7

M1 - 971

ER -

ID: 323982326