Diabetes complications and extracellular vesicle therapy

Research output: Contribution to journal › Review › Research › peer-review

Standard

Diabetes complications and extracellular vesicle therapy. / Soltani, Setareh; Mansouri, Kamran; Parvaneh, Shahram; Thakor, Avnesh S; Pociot, Flemming; Yarani, Reza.

In: Reviews in Endocrine and Metabolic Disorders, Vol. 23, 2022, p. 357–385.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Soltani, S, Mansouri, K, Parvaneh, S, Thakor, AS, Pociot, F & Yarani, R 2022, 'Diabetes complications and extracellular vesicle therapy', Reviews in Endocrine and Metabolic Disorders, vol. 23, pp. 357–385. https://doi.org/10.1007/s11154-021-09680-y

APA

Soltani, S., Mansouri, K., Parvaneh, S., Thakor, A. S., Pociot, F., & Yarani, R. (2022). Diabetes complications and extracellular vesicle therapy. Reviews in Endocrine and Metabolic Disorders, 23, 357–385. https://doi.org/10.1007/s11154-021-09680-y

Vancouver

Soltani S, Mansouri K, Parvaneh S, Thakor AS, Pociot F, Yarani R. Diabetes complications and extracellular vesicle therapy. Reviews in Endocrine and Metabolic Disorders. 2022;23:357–385. https://doi.org/10.1007/s11154-021-09680-y

Author

Soltani, Setareh ; Mansouri, Kamran ; Parvaneh, Shahram ; Thakor, Avnesh S ; Pociot, Flemming ; Yarani, Reza. / Diabetes complications and extracellular vesicle therapy. In: Reviews in Endocrine and Metabolic Disorders. 2022 ; Vol. 23. pp. 357–385.

Bibtex

@article{58921c90cd1644769db254862c7ba119,

title = "Diabetes complications and extracellular vesicle therapy",

abstract = "Diabetes is a chronic disorder characterized by dysregulated glycemic conditions. Diabetic complications include microvascular and macrovascular abnormalities and account for high morbidity and mortality rates in patients. Current clinical approaches for diabetic complications are limited to symptomatic treatments and tight control of blood sugar levels. Extracellular vesicles (EVs) released by somatic and stem cells have recently emerged as a new class of potent cell-free therapeutic delivery packets with a great potential to treat diabetic complications. EVs contain a mixture of bioactive molecules and can affect underlying pathological processes in favor of tissue healing. In addition, EVs have low immunogenicity and high storage capacity while maintaining nearly the same regenerative and immunomodulatory effects compared to current cell-based therapies. Therefore, EVs have received increasing attention for diabetes-related complications in recent years. In this review, we provide an outlook on diabetic complications and summarizes new knowledge and advances in EV applications. Moreover, we highlight recommendations for future EV-related research.",

author = "Setareh Soltani and Kamran Mansouri and Shahram Parvaneh and Thakor, {Avnesh S} and Flemming Pociot and Reza Yarani",

note = "{\textcopyright} 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",

year = "2022",

doi = "10.1007/s11154-021-09680-y",

language = "English",

volume = "23",

pages = "357–385",

journal = "Reviews in Endocrine and Metabolic Disorders",

issn = "1389-9155",

publisher = "Springer",

}

RIS

TY - JOUR

T1 - Diabetes complications and extracellular vesicle therapy

AU - Soltani, Setareh

AU - Mansouri, Kamran

AU - Parvaneh, Shahram

AU - Thakor, Avnesh S

AU - Pociot, Flemming

AU - Yarani, Reza

PY - 2022

Y1 - 2022

N2 - Diabetes is a chronic disorder characterized by dysregulated glycemic conditions. Diabetic complications include microvascular and macrovascular abnormalities and account for high morbidity and mortality rates in patients. Current clinical approaches for diabetic complications are limited to symptomatic treatments and tight control of blood sugar levels. Extracellular vesicles (EVs) released by somatic and stem cells have recently emerged as a new class of potent cell-free therapeutic delivery packets with a great potential to treat diabetic complications. EVs contain a mixture of bioactive molecules and can affect underlying pathological processes in favor of tissue healing. In addition, EVs have low immunogenicity and high storage capacity while maintaining nearly the same regenerative and immunomodulatory effects compared to current cell-based therapies. Therefore, EVs have received increasing attention for diabetes-related complications in recent years. In this review, we provide an outlook on diabetic complications and summarizes new knowledge and advances in EV applications. Moreover, we highlight recommendations for future EV-related research.

AB - Diabetes is a chronic disorder characterized by dysregulated glycemic conditions. Diabetic complications include microvascular and macrovascular abnormalities and account for high morbidity and mortality rates in patients. Current clinical approaches for diabetic complications are limited to symptomatic treatments and tight control of blood sugar levels. Extracellular vesicles (EVs) released by somatic and stem cells have recently emerged as a new class of potent cell-free therapeutic delivery packets with a great potential to treat diabetic complications. EVs contain a mixture of bioactive molecules and can affect underlying pathological processes in favor of tissue healing. In addition, EVs have low immunogenicity and high storage capacity while maintaining nearly the same regenerative and immunomodulatory effects compared to current cell-based therapies. Therefore, EVs have received increasing attention for diabetes-related complications in recent years. In this review, we provide an outlook on diabetic complications and summarizes new knowledge and advances in EV applications. Moreover, we highlight recommendations for future EV-related research.

U2 - 10.1007/s11154-021-09680-y

DO - 10.1007/s11154-021-09680-y

M3 - Review

C2 - 34647239

VL - 23

SP - 357

EP - 385

JO - Reviews in Endocrine and Metabolic Disorders

JF - Reviews in Endocrine and Metabolic Disorders

SN - 1389-9155

ER -

ID: 304785859