Epidemiology of hepatitis E virus infection in a cohort of 4023 immunocompromised patients
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Epidemiology of hepatitis E virus infection in a cohort of 4023 immunocompromised patients. / Harritshøj, Lene H.; Hother, Christoffer E.; Sengeløv, Henrik; Daugaard, Gedske; Sørensen, Søren S.; Jacobsen, Søren; Perch, Michael; Holm, Dorte K.; Sækmose, Susanne G.; Aagaard, Bitten; Erikstrup, Christian; Hogema, Boris M.; Lundgren, Jens D.; Ullum, Henrik.
In: International Journal of Infectious Diseases, Vol. 91, 2020, p. 188-195.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Epidemiology of hepatitis E virus infection in a cohort of 4023 immunocompromised patients
AU - Harritshøj, Lene H.
AU - Hother, Christoffer E.
AU - Sengeløv, Henrik
AU - Daugaard, Gedske
AU - Sørensen, Søren S.
AU - Jacobsen, Søren
AU - Perch, Michael
AU - Holm, Dorte K.
AU - Sækmose, Susanne G.
AU - Aagaard, Bitten
AU - Erikstrup, Christian
AU - Hogema, Boris M.
AU - Lundgren, Jens D.
AU - Ullum, Henrik
PY - 2020
Y1 - 2020
N2 - Objectives: The prevalence of active, chronic, and former hepatitis E virus (HEV) infections was investigated in a cohort of immunocompromised patients. The association with transfusion transmitted HEV was evaluated, and the HEV seroprevalence was compared with that in healthy blood donors. Study design and methods: Serum samples from 4023 immunocompromised patients at Rigshospitalet, Denmark were retrospectively tested for HEV RNA and anti-HEV IgG. HEV RNA-positive patients were followed up by HEV testing, clinical symptoms, and transfusion history. Factors associated with anti-HEV were explored by multivariable logistic regression analysis. Samples from 1226 blood donors were retrospectively tested for anti-HEV IgG. Results: HEV RNA was detected in six patients (0.15%) with no indications of chronic HEV infection. HEV RNA prevalence rates among recipients of allogeneic haematopoietic stem cell transplantation (allo-HSCT) and solid organ transplantation (SOT) were 0.58% and 0.21%, respectively. Transfusion transmitted infections were refuted, and transfusion history was not associated with anti-HEV positivity. The difference in HEV seroprevalence between patients (22.0%) and blood donors (10.9%) decreased when adjusting for age and sex (odds ratio 1.20, 95% confidence interval 0.97–1.48). Conclusions: HEV viremia among allo-HSCT and SOT recipients suggests that clinicians should be aware of this diagnosis. The lack of association of blood transfusion with anti-HEV positivity supports food-borne transmission as the main transmission route of HEV common to both patients and blood donors.
AB - Objectives: The prevalence of active, chronic, and former hepatitis E virus (HEV) infections was investigated in a cohort of immunocompromised patients. The association with transfusion transmitted HEV was evaluated, and the HEV seroprevalence was compared with that in healthy blood donors. Study design and methods: Serum samples from 4023 immunocompromised patients at Rigshospitalet, Denmark were retrospectively tested for HEV RNA and anti-HEV IgG. HEV RNA-positive patients were followed up by HEV testing, clinical symptoms, and transfusion history. Factors associated with anti-HEV were explored by multivariable logistic regression analysis. Samples from 1226 blood donors were retrospectively tested for anti-HEV IgG. Results: HEV RNA was detected in six patients (0.15%) with no indications of chronic HEV infection. HEV RNA prevalence rates among recipients of allogeneic haematopoietic stem cell transplantation (allo-HSCT) and solid organ transplantation (SOT) were 0.58% and 0.21%, respectively. Transfusion transmitted infections were refuted, and transfusion history was not associated with anti-HEV positivity. The difference in HEV seroprevalence between patients (22.0%) and blood donors (10.9%) decreased when adjusting for age and sex (odds ratio 1.20, 95% confidence interval 0.97–1.48). Conclusions: HEV viremia among allo-HSCT and SOT recipients suggests that clinicians should be aware of this diagnosis. The lack of association of blood transfusion with anti-HEV positivity supports food-borne transmission as the main transmission route of HEV common to both patients and blood donors.
KW - Anti-HEV IgG
KW - Chronic HEV infection
KW - Epidemiology
KW - Hepatitis E
KW - HEV RNA
KW - Immunocompromised
KW - Transfusion transmission
U2 - 10.1016/j.ijid.2019.11.014
DO - 10.1016/j.ijid.2019.11.014
M3 - Journal article
C2 - 31756566
AN - SCOPUS:85076685441
VL - 91
SP - 188
EP - 195
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
SN - 1201-9712
ER -
ID: 235589790