Estimation of SARS-CoV-2 Infection Fatality Rate by Age and Comorbidity Status Using Antibody Screening of Blood Donors during the COVID-19 Epidemic in Denmark
Research output: Contribution to journal › Journal article › Research › peer-review
Background: Studies presenting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) for healthy individuals are warranted. We estimate IFR by age and comorbidity status using data from a large serosurvey among Danish blood donors and nationwide data on coronavirus disease 2019 (COVID-19) mortality. Methods: Danish blood donors aged 17-69 years donating blood October 2020-February 2021 were tested with a commercial SARS-CoV-2 total antibody assay. IFR was estimated for weeks 11 to 42, 2020 and week 43, 2020 to week 6, 2021, representing the first 2 waves of COVID-19 epidemic in Denmark. Results: In total, 84944 blood donors were tested for antibodies. The seroprevalence was 2% in October 2020 and 7% in February 2021. Among 3898039 Danish residents aged 17-69 years, 249 deaths were recorded. The IFR was low for people <51 years without comorbidity during the 2 waves (combined IFR=3.36 per 100000 infections). The IFR was below 3‰ for people aged 61-69 years without comorbidity. IFR increased with age and comorbidity but declined from the first to second wave. Conclusions: In this nationwide study, the IFR was very low among people <51 years without comorbidity.
Original language | English |
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Journal | Journal of Infectious Diseases |
Volume | 225 |
Issue number | 2 |
Pages (from-to) | 219-228 |
Number of pages | 10 |
ISSN | 0022-1899 |
DOIs | |
Publication status | Published - 2022 |
Bibliographical note
Publisher Copyright:
© 2021 The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
- blood donors, infection fatality rate, SARS-CoV-2, seroprevalence
Research areas
Links
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689980/pdf/jiab566.pdf
Final published version
ID: 321550546