Evaluation of MIC Strip Isavuconazole test for susceptibility testing of wild-type and non-wild-type Aspergillus fumigatus isolates
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- Evaluation of MIC Strip Isavuconazole Test for Susceptibility Testing of Wild- Type and Non-Wild-Type Aspergillus fumigatus Isolates
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We evaluated the MIC Strip Isavuconazole test against EUCAST E.Def 9.3 by using 40 wild-type and 39 CYP51A mutant Aspergillus fumigatus strains. The strip full inhibition endpoint (FIE) and 80% growth inhibition endpoint were determined by two independent readers, reader 1 (R1) and R2. The essential (within ±0, ±1, and ±2 twofold dilutions) and categorical agreements were best with the FIE (for R1/R2, 42%/41%, 75%/73%, and 90%/89% for essential agreement, and 91.1%/92.4% categorical agreement, with 6.3/8.9% very major errors and 0/1.3% major errors, respectively). The MIC Strip Isavuconazole test with the FIE appears to be useful.
Original language | English |
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Article number | e01659-16 |
Journal | Antimicrobial Agents and Chemotherapy |
Volume | 61 |
Issue number | 1 |
Number of pages | 5 |
ISSN | 0066-4804 |
DOIs | |
Publication status | Published - Jan 2017 |
- Antifungal susceptibility testing, Aspergillus fumigatus, Cyp51A mutants, EUCAST, Gradient strip, Isavuconazole, MIC, Wild type
Research areas
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