Exercise training to increase tumour natural killer-cell infiltration in men with localised prostate cancer: a randomised controlled trial
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Exercise training to increase tumour natural killer-cell infiltration in men with localised prostate cancer : a randomised controlled trial. / Djurhuus, Sissal Sigmundsdóttir; Simonsen, Casper; Toft, Birgitte Grønkær; Thomsen, Simon Nørskov; Wielsøe, Sabrina; Røder, Martin Andreas; Hasselager, Thomas; Østergren, Peter Busch; Jakobsen, Henrik; Pedersen, Bente Klarlund; Hojman, Pernille; Brasso, Klaus; Christensen, Jesper Frank.
In: BJU International, Vol. 131, No. 1, 2023, p. 116-124.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Exercise training to increase tumour natural killer-cell infiltration in men with localised prostate cancer
T2 - a randomised controlled trial
AU - Djurhuus, Sissal Sigmundsdóttir
AU - Simonsen, Casper
AU - Toft, Birgitte Grønkær
AU - Thomsen, Simon Nørskov
AU - Wielsøe, Sabrina
AU - Røder, Martin Andreas
AU - Hasselager, Thomas
AU - Østergren, Peter Busch
AU - Jakobsen, Henrik
AU - Pedersen, Bente Klarlund
AU - Hojman, Pernille
AU - Brasso, Klaus
AU - Christensen, Jesper Frank
N1 - Publisher Copyright: © 2022 The Authors. BJU International published by John Wiley & Sons Ltd on behalf of BJU International.
PY - 2023
Y1 - 2023
N2 - Objectives: To explore the effects of preoperative high-intensity interval training (HIIT) compared to usual care on tumour natural killer (NK)-cell infiltration in men with localised prostate cancer (PCa), as NK-cell infiltration has been proposed as one of the key mechanisms whereby exercise can modulate human tumours. Patients and Methods: A total of 30 patients with localised PCa undergoing radical prostatectomy (RP) were randomised (2:1) to either preoperative aerobic HIIT four-times weekly (EX; n = 20) or usual care (CON; n = 10) from time of inclusion until scheduled surgery. Tumour NK-cell infiltration was assessed by immunohistochemistry (CD56+) in diagnostic core needle biopsies and corresponding prostatic tissue from the RP. Changes in cardiorespiratory fitness, body composition, blood biochemistry, and health-related quality of life were also evaluated. Results: The change in tumour NK-cell infiltration did not differ between the EX and CON groups (between-group difference: −0.09 cells/mm2, 95% confidence interval [CI] –1.85 to 1.66; P = 0.913) in the intention-to-treat analysis. The total number of exercise sessions varied considerably from four to 30 sessions. The per-protocol analysis showed a significant increase in tumour NK-cell infiltration of 1.60 cells/mm2 (95% CI 0.59 to 2.62; P = 0.004) in the EX group. Further, the total number of training sessions was positively correlated with the change in NK-cell infiltration (r = 0.526, P = 0.021), peak oxygen uptake (r = 0.514, P = 0.035) and peak power output (r = 0.506, P = 0.038). Conclusion: Preoperative HIIT did not result in between-group differences in tumour NK-cell infiltration. Per-protocol and exploratory analyses demonstrate an enhanced NK-cell infiltration in PCa. Future studies are needed to test the capability of exercise to increase tumour immune cell infiltration.
AB - Objectives: To explore the effects of preoperative high-intensity interval training (HIIT) compared to usual care on tumour natural killer (NK)-cell infiltration in men with localised prostate cancer (PCa), as NK-cell infiltration has been proposed as one of the key mechanisms whereby exercise can modulate human tumours. Patients and Methods: A total of 30 patients with localised PCa undergoing radical prostatectomy (RP) were randomised (2:1) to either preoperative aerobic HIIT four-times weekly (EX; n = 20) or usual care (CON; n = 10) from time of inclusion until scheduled surgery. Tumour NK-cell infiltration was assessed by immunohistochemistry (CD56+) in diagnostic core needle biopsies and corresponding prostatic tissue from the RP. Changes in cardiorespiratory fitness, body composition, blood biochemistry, and health-related quality of life were also evaluated. Results: The change in tumour NK-cell infiltration did not differ between the EX and CON groups (between-group difference: −0.09 cells/mm2, 95% confidence interval [CI] –1.85 to 1.66; P = 0.913) in the intention-to-treat analysis. The total number of exercise sessions varied considerably from four to 30 sessions. The per-protocol analysis showed a significant increase in tumour NK-cell infiltration of 1.60 cells/mm2 (95% CI 0.59 to 2.62; P = 0.004) in the EX group. Further, the total number of training sessions was positively correlated with the change in NK-cell infiltration (r = 0.526, P = 0.021), peak oxygen uptake (r = 0.514, P = 0.035) and peak power output (r = 0.506, P = 0.038). Conclusion: Preoperative HIIT did not result in between-group differences in tumour NK-cell infiltration. Per-protocol and exploratory analyses demonstrate an enhanced NK-cell infiltration in PCa. Future studies are needed to test the capability of exercise to increase tumour immune cell infiltration.
KW - #PCSM
KW - #ProstateCancer
KW - #uroonc
KW - exercise
KW - high-intensity exercise training
KW - immune cells
KW - NK cells
KW - preoperative
KW - prostate cancer
U2 - 10.1111/bju.15842
DO - 10.1111/bju.15842
M3 - Journal article
C2 - 35753072
AN - SCOPUS:85134170952
VL - 131
SP - 116
EP - 124
JO - BJU International
JF - BJU International
SN - 1464-4096
IS - 1
ER -
ID: 321951144