For men enrolled in active surveillance, pre-biopsy biparametric magnetic resonance imaging significantly reduces the risk of reclassification and disease progression after 1 year
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For men enrolled in active surveillance, pre-biopsy biparametric magnetic resonance imaging significantly reduces the risk of reclassification and disease progression after 1 year. / Kortenbach, Karen Cecilie; Boesen, Lars; Løgager, Vibeke; Thomsen, Henrik S.
In: Scandinavian Journal of Urology, Vol. 55, No. 3, 2021, p. 215-220.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - For men enrolled in active surveillance, pre-biopsy biparametric magnetic resonance imaging significantly reduces the risk of reclassification and disease progression after 1 year
AU - Kortenbach, Karen Cecilie
AU - Boesen, Lars
AU - Løgager, Vibeke
AU - Thomsen, Henrik S.
N1 - Publisher Copyright: © 2021 Acta Chirurgica Scandinavica Society.
PY - 2021
Y1 - 2021
N2 - Aims: To assess the level of disease progression at confirmatory staging biopsies after 1 year of active surveillance (AS) and compare the detection rate of significant prostate cancers (PCas) in patients who underwent pre-biopsy biparametric magnetic resonance imaging (bpMRI) before the first set of diagnostic transrectal ultrasonography-guided biopsies (TRUS-bx) with the detection rate in patients who did not undergo pre-biopsy bpMRI. Materials and methods: Comparison of two patient groups enrolled in AS. Patients in Group A (n = 127) underwent pre-biopsy bpMRI followed by TRUS-bx ± targeted biopsies. Patients in Group B (n = 127) were enrolled in AS based on biopsy results from TRUS-bx only. Results: Overall, 6% of the patients in Group A and 20% of the patients in Group B had an upgrade in Gleason grade from insignificant to significant PCa at confirmatory staging biopsies (odds ratio [OR], 3.5; p =.002; 95% confidence interval [CI], 1.6–7.9). Conclusions: Patients who underwent pre-biopsy bpMRI before the first set of diagnostic biopsies had a reduced risk of reclassification and disease progression after 1 year of AS. Thus, pre-biopsy bpMRI improves the selection of men who should be enrolled in AS.
AB - Aims: To assess the level of disease progression at confirmatory staging biopsies after 1 year of active surveillance (AS) and compare the detection rate of significant prostate cancers (PCas) in patients who underwent pre-biopsy biparametric magnetic resonance imaging (bpMRI) before the first set of diagnostic transrectal ultrasonography-guided biopsies (TRUS-bx) with the detection rate in patients who did not undergo pre-biopsy bpMRI. Materials and methods: Comparison of two patient groups enrolled in AS. Patients in Group A (n = 127) underwent pre-biopsy bpMRI followed by TRUS-bx ± targeted biopsies. Patients in Group B (n = 127) were enrolled in AS based on biopsy results from TRUS-bx only. Results: Overall, 6% of the patients in Group A and 20% of the patients in Group B had an upgrade in Gleason grade from insignificant to significant PCa at confirmatory staging biopsies (odds ratio [OR], 3.5; p =.002; 95% confidence interval [CI], 1.6–7.9). Conclusions: Patients who underwent pre-biopsy bpMRI before the first set of diagnostic biopsies had a reduced risk of reclassification and disease progression after 1 year of AS. Thus, pre-biopsy bpMRI improves the selection of men who should be enrolled in AS.
KW - Active surveillance
KW - biparametric magnetic resonance imaging
KW - multiparametric magnetic resonance imaging
KW - prostate cancer
UR - http://www.scopus.com/inward/record.url?scp=85102947564&partnerID=8YFLogxK
U2 - 10.1080/21681805.2021.1897158
DO - 10.1080/21681805.2021.1897158
M3 - Journal article
C2 - 33749511
AN - SCOPUS:85102947564
VL - 55
SP - 215
EP - 220
JO - Scandinavian Journal of Urology
JF - Scandinavian Journal of Urology
SN - 2168-1805
IS - 3
ER -
ID: 305002194