Global constructive work is associated with ventricular arrhythmias after cardiac resynchronization therapy

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Standard

Global constructive work is associated with ventricular arrhythmias after cardiac resynchronization therapy. / Saffi, Hillah; Winsløw, Ulrik; Sakthivel, Tharsika; Højgaard, Emma Vinther; Linde, Jesper; Philbert, Berit; Vinther, Michael; Jøns, Christian; Bundgaard, Henning; Risum, Niels.

In: European Heart Journal Cardiovascular Imaging, Vol. 25, No. 1, 2024, p. 29-36.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Saffi, H, Winsløw, U, Sakthivel, T, Højgaard, EV, Linde, J, Philbert, B, Vinther, M, Jøns, C, Bundgaard, H & Risum, N 2024, 'Global constructive work is associated with ventricular arrhythmias after cardiac resynchronization therapy', European Heart Journal Cardiovascular Imaging, vol. 25, no. 1, pp. 29-36. https://doi.org/10.1093/ehjci/jead180

APA

Saffi, H., Winsløw, U., Sakthivel, T., Højgaard, E. V., Linde, J., Philbert, B., Vinther, M., Jøns, C., Bundgaard, H., & Risum, N. (2024). Global constructive work is associated with ventricular arrhythmias after cardiac resynchronization therapy. European Heart Journal Cardiovascular Imaging, 25(1), 29-36. https://doi.org/10.1093/ehjci/jead180

Vancouver

Saffi H, Winsløw U, Sakthivel T, Højgaard EV, Linde J, Philbert B et al. Global constructive work is associated with ventricular arrhythmias after cardiac resynchronization therapy. European Heart Journal Cardiovascular Imaging. 2024;25(1):29-36. https://doi.org/10.1093/ehjci/jead180

Author

Saffi, Hillah ; Winsløw, Ulrik ; Sakthivel, Tharsika ; Højgaard, Emma Vinther ; Linde, Jesper ; Philbert, Berit ; Vinther, Michael ; Jøns, Christian ; Bundgaard, Henning ; Risum, Niels. / Global constructive work is associated with ventricular arrhythmias after cardiac resynchronization therapy. In: European Heart Journal Cardiovascular Imaging. 2024 ; Vol. 25, No. 1. pp. 29-36.

Bibtex

@article{0ed38c5527ae4dddbf530bcd72240552,

title = "Global constructive work is associated with ventricular arrhythmias after cardiac resynchronization therapy",

abstract = "Aims Non-invasive left ventricular (LV) pressure–strain loops provide a novel method for quantifying myocardial work by incorporating LV pressure in measurements of myocardial deformation. Early studies suggest that myocardial work parameters such as global constructive work (GCW) could be useful and reliable in arrhythmia prediction, particularly in patients undergoing cardiac resynchronization therapy (CRT). The aim of this study was to evaluate whether the magnitude of GCW was associated with the occurrence of ventricular arrhythmias in patients after CRT. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Methods Patients on guideline-recommended treatment with a CRT defibrillator (CRT-D) were evaluated by 2D speckle-tracking and results echocardiography including measurements of GCW at least 6 months after implantation. The primary outcome was a composite of appropriate defibrillator therapy and sustained ventricular arrhythmia under the monitor zone. A total of 162 patients [mean age 66 years (±10), 122 males (75%)] were included. Sixteen (10%) patients experienced the primary outcome during a median follow-up of 18 months (interquartile range: 12–25) after the performance of index echocardiography. Patients with a below-median GCW (<1473 mmHg%) had a hazard ratio (HR) for the outcome of 8.14 [95% confidence interval (CI): 1.83–36.08], P = 0.006 compared with patients above the median in a univariate model and remained an independent predictor after multivariate adjustment for the estimated glomerular filtration rate and QRS duration [HR 4.75 (95% CI: 1.01–22.28), P < 0.05]. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Conclusion In patients treated with CRT-D, a GCW below median level was associated with a five-fold increase in the risk of ventricular arrhythmias.",

keywords = "cardiac resynchronization therapy defibrillator, dyssynchrony, global constructive work, global longitudinal strain, speckle tracking, ventricular arrhythmias",

author = "Hillah Saffi and Ulrik Winsl{\o}w and Tharsika Sakthivel and H{\o}jgaard, {Emma Vinther} and Jesper Linde and Berit Philbert and Michael Vinther and Christian J{\o}ns and Henning Bundgaard and Niels Risum",

year = "2024",

doi = "10.1093/ehjci/jead180",

language = "English",

volume = "25",

pages = "29--36",

journal = "European Heart Journal Cardiovascular Imaging",

issn = "2047-2404",

publisher = "Oxford University Press",

number = "1",

}

RIS

TY - JOUR

T1 - Global constructive work is associated with ventricular arrhythmias after cardiac resynchronization therapy

AU - Saffi, Hillah

AU - Winsløw, Ulrik

AU - Sakthivel, Tharsika

AU - Højgaard, Emma Vinther

AU - Linde, Jesper

AU - Philbert, Berit

AU - Vinther, Michael

AU - Jøns, Christian

AU - Bundgaard, Henning

AU - Risum, Niels

PY - 2024

Y1 - 2024

N2 - Aims Non-invasive left ventricular (LV) pressure–strain loops provide a novel method for quantifying myocardial work by incorporating LV pressure in measurements of myocardial deformation. Early studies suggest that myocardial work parameters such as global constructive work (GCW) could be useful and reliable in arrhythmia prediction, particularly in patients undergoing cardiac resynchronization therapy (CRT). The aim of this study was to evaluate whether the magnitude of GCW was associated with the occurrence of ventricular arrhythmias in patients after CRT. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Methods Patients on guideline-recommended treatment with a CRT defibrillator (CRT-D) were evaluated by 2D speckle-tracking and results echocardiography including measurements of GCW at least 6 months after implantation. The primary outcome was a composite of appropriate defibrillator therapy and sustained ventricular arrhythmia under the monitor zone. A total of 162 patients [mean age 66 years (±10), 122 males (75%)] were included. Sixteen (10%) patients experienced the primary outcome during a median follow-up of 18 months (interquartile range: 12–25) after the performance of index echocardiography. Patients with a below-median GCW (<1473 mmHg%) had a hazard ratio (HR) for the outcome of 8.14 [95% confidence interval (CI): 1.83–36.08], P = 0.006 compared with patients above the median in a univariate model and remained an independent predictor after multivariate adjustment for the estimated glomerular filtration rate and QRS duration [HR 4.75 (95% CI: 1.01–22.28), P < 0.05]. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Conclusion In patients treated with CRT-D, a GCW below median level was associated with a five-fold increase in the risk of ventricular arrhythmias.

AB - Aims Non-invasive left ventricular (LV) pressure–strain loops provide a novel method for quantifying myocardial work by incorporating LV pressure in measurements of myocardial deformation. Early studies suggest that myocardial work parameters such as global constructive work (GCW) could be useful and reliable in arrhythmia prediction, particularly in patients undergoing cardiac resynchronization therapy (CRT). The aim of this study was to evaluate whether the magnitude of GCW was associated with the occurrence of ventricular arrhythmias in patients after CRT. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Methods Patients on guideline-recommended treatment with a CRT defibrillator (CRT-D) were evaluated by 2D speckle-tracking and results echocardiography including measurements of GCW at least 6 months after implantation. The primary outcome was a composite of appropriate defibrillator therapy and sustained ventricular arrhythmia under the monitor zone. A total of 162 patients [mean age 66 years (±10), 122 males (75%)] were included. Sixteen (10%) patients experienced the primary outcome during a median follow-up of 18 months (interquartile range: 12–25) after the performance of index echocardiography. Patients with a below-median GCW (<1473 mmHg%) had a hazard ratio (HR) for the outcome of 8.14 [95% confidence interval (CI): 1.83–36.08], P = 0.006 compared with patients above the median in a univariate model and remained an independent predictor after multivariate adjustment for the estimated glomerular filtration rate and QRS duration [HR 4.75 (95% CI: 1.01–22.28), P < 0.05]. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Conclusion In patients treated with CRT-D, a GCW below median level was associated with a five-fold increase in the risk of ventricular arrhythmias.

KW - cardiac resynchronization therapy defibrillator

KW - dyssynchrony

KW - global constructive work

KW - global longitudinal strain

KW - speckle tracking

KW - ventricular arrhythmias

U2 - 10.1093/ehjci/jead180

DO - 10.1093/ehjci/jead180

M3 - Journal article

C2 - 37490039

AN - SCOPUS:85181176339

VL - 25

SP - 29

EP - 36

JO - European Heart Journal Cardiovascular Imaging

JF - European Heart Journal Cardiovascular Imaging

SN - 2047-2404

IS - 1

ER -

ID: 382382937