Implementation of TERT promoter mutations improve prognostication of the WHO classification in meningioma
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TERT promoter mutations have been associated with increased risk of recurrence in meningioma cohorts, thus a potential biomarker for aggressive phenotypes. A main purpose of refining tumour classification is better predictions on the patient level. We compiled data from previous published cohorts to investigate patient-level predictions of recurrence based on TERTp-mut status. Implementation of TERTp-mut into the WHO grading led to better patient prognostication by improved prediction of recurrence. Our results support implementation of TERTp-mut into diagnostics and classification of meningiomas
Original language | English |
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Article number | e12773 |
Journal | Neuropathology and Applied Neurobiology |
Volume | 48 |
Issue number | 3 |
Number of pages | 5 |
ISSN | 0305-1846 |
DOIs | |
Publication status | Published - 2022 |
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