Metabolic Profiling Early Post-Allogeneic Haematopoietic Cell Transplantation in the Context of CMV Infection
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Metabolic Profiling Early Post-Allogeneic Haematopoietic Cell Transplantation in the Context of CMV Infection. / Rasmussen, Kirstine K.; dos Santos, Quenia; MacPherson, Cameron Ross; Zucco, Adrian G.; Gjærde, Lars Klingen; Ilett, Emma E.; Lodding, Isabelle; Helleberg, Marie; Lundgren, Jens D.; Nielsen, Susanne D.; Brix, Susanne; Sengeløv, Henrik; Murray, Daniel D.
In: Metabolites, Vol. 13, No. 9, 968, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Metabolic Profiling Early Post-Allogeneic Haematopoietic Cell Transplantation in the Context of CMV Infection
AU - Rasmussen, Kirstine K.
AU - dos Santos, Quenia
AU - MacPherson, Cameron Ross
AU - Zucco, Adrian G.
AU - Gjærde, Lars Klingen
AU - Ilett, Emma E.
AU - Lodding, Isabelle
AU - Helleberg, Marie
AU - Lundgren, Jens D.
AU - Nielsen, Susanne D.
AU - Brix, Susanne
AU - Sengeløv, Henrik
AU - Murray, Daniel D.
N1 - Publisher Copyright: © 2023 by the authors.
PY - 2023
Y1 - 2023
N2 - Immune dysfunction resulting from allogeneic haematopoietic stem cell transplantation (aHSCT) predisposes one to an elevated risk of cytomegalovirus (CMV) infection. Changes in metabolism have been associated with adverse outcomes, and in this study, we explored the associations between metabolic profiles and post-transplantation CMV infection using plasma samples collected 7–33 days after aHSCT. We included 68 aHSCT recipients from Rigshospitalet, Denmark, 50% of whom experienced CMV infection between days 34–100 post-transplantation. First, we investigated whether 12 metabolites selected based on the literature were associated with an increased risk of post-transplantation CMV infection. Second, we conducted an exploratory network-based analysis of the complete metabolic and lipidomic profiles in relation to clinical phenotypes and biological pathways. Lower levels of trimethylamine N-oxide were associated with subsequent CMV infection (multivariable logistic regression: OR = 0.63; 95% CI = [0.41; 0.87]; p = 0.01). Explorative analysis revealed 12 clusters of metabolites or lipids, among which one was predictive of CMV infection, and the others were associated with conditioning regimens, age upon aHSCT, CMV serostatus, and/or sex. Our results provide evidence for an association between the metabolome and CMV infection post-aHSCT that is independent of known risk factors.
AB - Immune dysfunction resulting from allogeneic haematopoietic stem cell transplantation (aHSCT) predisposes one to an elevated risk of cytomegalovirus (CMV) infection. Changes in metabolism have been associated with adverse outcomes, and in this study, we explored the associations between metabolic profiles and post-transplantation CMV infection using plasma samples collected 7–33 days after aHSCT. We included 68 aHSCT recipients from Rigshospitalet, Denmark, 50% of whom experienced CMV infection between days 34–100 post-transplantation. First, we investigated whether 12 metabolites selected based on the literature were associated with an increased risk of post-transplantation CMV infection. Second, we conducted an exploratory network-based analysis of the complete metabolic and lipidomic profiles in relation to clinical phenotypes and biological pathways. Lower levels of trimethylamine N-oxide were associated with subsequent CMV infection (multivariable logistic regression: OR = 0.63; 95% CI = [0.41; 0.87]; p = 0.01). Explorative analysis revealed 12 clusters of metabolites or lipids, among which one was predictive of CMV infection, and the others were associated with conditioning regimens, age upon aHSCT, CMV serostatus, and/or sex. Our results provide evidence for an association between the metabolome and CMV infection post-aHSCT that is independent of known risk factors.
KW - aHSCT
KW - CMV
KW - correlation network analysis
KW - cytomegalovirus
KW - lipidomics
KW - metabolomics
KW - TMAO
KW - WGCNA
U2 - 10.3390/metabo13090968
DO - 10.3390/metabo13090968
M3 - Journal article
C2 - 37755248
AN - SCOPUS:85172475835
VL - 13
JO - Metabolites
JF - Metabolites
SN - 2218-1989
IS - 9
M1 - 968
ER -
ID: 369290817