Neutralizing antibodies hamper IFNbeta bioactivity and treatment effect on MRI in patients with MS

Research output: Contribution to journalJournal articleResearchpeer-review

We measured neutralizing antibodies (NABs) and the in vivo biologic response to interferon-beta on neopterin and beta(2)-microglobulin blood levels. All NAB-negative patients had an in vivo biologic response (full or partial), whereas all high-level positive patients had no response. High-level NAB patients had more MRI activity than NAB-negative patients (p = 0.031). Patients with a full response had less MRI activity than patients without biologic response (p = 0.032).
Original languageEnglish
JournalNeurology
Volume67
Issue number9
Pages (from-to)1681-83
ISSN0028-3878
DOIs
Publication statusPublished - 2006

ID: 34074971