Non-BRCA1/BRCA2 high-risk familial breast cancers are not associated with a high prevalence of BRCAness
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Background: Familial breast cancer is in most cases unexplained due to the lack of identifiable pathogenic variants in the BRCA1 and BRCA2 genes. The somatic mutational landscape and in particular the extent of BRCA-like tumour features (BRCAness) in these familial breast cancers where germline BRCA1 or BRCA2 mutations have not been identified is to a large extent unknown. Methods: We performed whole-genome sequencing on matched tumour and normal samples from high-risk non-BRCA1/BRCA2 breast cancer families to understand the germline and somatic mutational landscape and mutational signatures. We measured BRCAness using HRDetect. As a comparator, we also analysed samples from BRCA1 and BRCA2 germline mutation carriers. Results: We noted for non-BRCA1/BRCA2 tumours, only a small proportion displayed high HRDetect scores and were characterized by concomitant promoter hypermethylation or in one case a RAD51D splice variant previously reported as having unknown significance to potentially explain their BRCAness. Another small proportion showed no features of BRCAness but had mutationally active tumours. The remaining tumours lacked features of BRCAness and were mutationally quiescent. Conclusions: A limited fraction of high-risk familial non-BRCA1/BRCA2 breast cancer patients is expected to benefit from treatment strategies against homologue repair deficient cancer cells.
Original language | English |
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Article number | 69 |
Journal | Breast Cancer Research |
Volume | 25 |
Issue number | 1 |
Number of pages | 10 |
ISSN | 1465-5411 |
DOIs | |
Publication status | Published - 2023 |
Bibliographical note
Funding Information:
Open access funding provided by University Library of Southern Denmark. This work was supported by funding from the Danish Cancer Society (Journal number R146-A9247-16-S2), Dansk Kræftforskningfond (Journal number 153/1), The Odense University Hospital Fund for Free Research, Faculty of Health Sciences at the University of Southern Denmark, Karen Elise Jensen Foundation, Dagmar Marshalls Foundation, Snedkermester Sophus Jacobsens og hustru Astrid Jacobsens Foundation, Arvid Nilssons Foundation and Overlægerådets Research Foundation.
Publisher Copyright:
© 2023, The Author(s).
- BRCAness, Breast cancer, Hereditary breast cancer, HRDetect, Mutational signatures, Non-BRCA1/BRCA2, Whole genome sequencing
Research areas
ID: 373036569