Prostate artery embolization for lower urinary tract symptoms in men unfit for surgery
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Prostate artery embolization for lower urinary tract symptoms in men unfit for surgery. / Malling, Brian; Lönn, Lars; Jensen, Ruben Juhl; Lindh, Mats; Frevert, Susanne; Brasso, Klaus; Røder, Martin Andreas.
In: Diagnostics, Vol. 9, No. 2, 46, 2019.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Prostate artery embolization for lower urinary tract symptoms in men unfit for surgery
AU - Malling, Brian
AU - Lönn, Lars
AU - Jensen, Ruben Juhl
AU - Lindh, Mats
AU - Frevert, Susanne
AU - Brasso, Klaus
AU - Røder, Martin Andreas
PY - 2019
Y1 - 2019
N2 - Nearly one in three men develop lower urinary tract symptoms (LUTS) and 10% clinically progress despite medication. Transurethral resection of the prostate (TURP) is the reference standard for symptoms refractory to medical treatment. However, some patients cannot tolerate TURP for medical (e.g., comorbidity) or technical (e.g., large prostate) reasons. This study estimated the safety and effect of prostate artery embolization (PAE) in men unfit for surgery. A prospective, single-centre trial including men with LUTS or urinary retention secondary to benign prostatic hyperplasia (BPH) who were unfit for surgery. The primary objective was to treat urinary retention and LUTS. Outcome measures included International Prostate Symptom Score (IPSS), quality of life (IPSS-QoL), International Index of Erectile Function (IIEF-5), prostate volume (PV), prostate-specific antigen (PSA), peak void flow (Qmax), post-void residual (PVR), and complications. A p-value < 0.05 was considered statistically significant. Eleven consecutive patients with a mean age of 75.2 (SD ± 8.2) underwent PAE. Catheter removal was successful in 60%. IPSS-QoL improved 4.5 points (95% CI: −5.6; −3.4), and PV was reduced by 26.2 cm3 (95% CI: −50.9; −2.3). None of the remaining outcomes changed. No major complications occurred. PAE was effective and safe for LUTS and urinary retention associated with BPH in men unfit for surgery.
AB - Nearly one in three men develop lower urinary tract symptoms (LUTS) and 10% clinically progress despite medication. Transurethral resection of the prostate (TURP) is the reference standard for symptoms refractory to medical treatment. However, some patients cannot tolerate TURP for medical (e.g., comorbidity) or technical (e.g., large prostate) reasons. This study estimated the safety and effect of prostate artery embolization (PAE) in men unfit for surgery. A prospective, single-centre trial including men with LUTS or urinary retention secondary to benign prostatic hyperplasia (BPH) who were unfit for surgery. The primary objective was to treat urinary retention and LUTS. Outcome measures included International Prostate Symptom Score (IPSS), quality of life (IPSS-QoL), International Index of Erectile Function (IIEF-5), prostate volume (PV), prostate-specific antigen (PSA), peak void flow (Qmax), post-void residual (PVR), and complications. A p-value < 0.05 was considered statistically significant. Eleven consecutive patients with a mean age of 75.2 (SD ± 8.2) underwent PAE. Catheter removal was successful in 60%. IPSS-QoL improved 4.5 points (95% CI: −5.6; −3.4), and PV was reduced by 26.2 cm3 (95% CI: −50.9; −2.3). None of the remaining outcomes changed. No major complications occurred. PAE was effective and safe for LUTS and urinary retention associated with BPH in men unfit for surgery.
KW - Clinical trial
KW - Embolization
KW - Interventional
KW - Lower urinary tract symptoms
KW - Prostatic hyperplasia
KW - Radiology
KW - Therapeutic
KW - Urinary retention
U2 - 10.3390/diagnostics9020046
DO - 10.3390/diagnostics9020046
M3 - Journal article
C2 - 31027211
AN - SCOPUS:85066629626
VL - 9
JO - Diagnostics
JF - Diagnostics
SN - 2075-4418
IS - 2
M1 - 46
ER -
ID: 236018565