Alterations in osteoclast function and phenotype induced by different inhibitors of bone resorption--implications for osteoclast quality
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Alterations in osteoclast function and phenotype induced by different inhibitors of bone resorption--implications for osteoclast quality. / Neutzsky-Wulff, Anita V; Sørensen, Mette Guldmann; Kocijancic, Dino; Leeming, Diana Julie; Dziegiel, Morten H; Karsdal, Morten A; Henriksen, Kim Steen.
In: B M C Musculoskeletal Disorders, Vol. 11, 01.01.2010, p. 109.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Alterations in osteoclast function and phenotype induced by different inhibitors of bone resorption--implications for osteoclast quality
AU - Neutzsky-Wulff, Anita V
AU - Sørensen, Mette Guldmann
AU - Kocijancic, Dino
AU - Leeming, Diana Julie
AU - Dziegiel, Morten H
AU - Karsdal, Morten A
AU - Henriksen, Kim Steen
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Normal osteoclasts resorb bone by secretion of acid and proteases. Recent studies of patients with loss of function mutations affecting either of these processes have indicated a divergence in osteoclastic phenotypes. These difference in osteoclast phenotypes may directly or indirectly have secondary effects on bone remodeling, a process which is of importance for the pathogenesis of both osteoporosis and osteoarthritis. We treated human osteoclasts with different inhibitors and characterized their resulting function.
AB - Normal osteoclasts resorb bone by secretion of acid and proteases. Recent studies of patients with loss of function mutations affecting either of these processes have indicated a divergence in osteoclastic phenotypes. These difference in osteoclast phenotypes may directly or indirectly have secondary effects on bone remodeling, a process which is of importance for the pathogenesis of both osteoporosis and osteoarthritis. We treated human osteoclasts with different inhibitors and characterized their resulting function.
U2 - http://dx.doi.org/10.1186/1471-2474-11-109
DO - http://dx.doi.org/10.1186/1471-2474-11-109
M3 - Journal article
VL - 11
SP - 109
JO - B M C Musculoskeletal Disorders
JF - B M C Musculoskeletal Disorders
SN - 1471-2474
ER -
ID: 34184481