Alterations in osteoclast function and phenotype induced by different inhibitors of bone resorption--implications for osteoclast quality
Research output: Contribution to journal › Journal article › Research › peer-review
Normal osteoclasts resorb bone by secretion of acid and proteases. Recent studies of patients with loss of function mutations affecting either of these processes have indicated a divergence in osteoclastic phenotypes. These difference in osteoclast phenotypes may directly or indirectly have secondary effects on bone remodeling, a process which is of importance for the pathogenesis of both osteoporosis and osteoarthritis. We treated human osteoclasts with different inhibitors and characterized their resulting function.
Original language | English |
---|---|
Journal | B M C Musculoskeletal Disorders |
Volume | 11 |
Pages (from-to) | 109 |
ISSN | 1471-2474 |
DOIs | |
Publication status | Published - 1 Jan 2010 |
ID: 34184481