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Degradation of the organic phase of bone by osteoclasts : a secondary role for lysosomal acidification. / Henriksen, Kim; Sørensen, Mette G; Nielsen, Rasmus H; Gram, Jeppe; Schaller, Sophie; Dziegiel, Morten Hanefeld; Everts, Vincent; Bollerslev, Jens; Karsdal, Morten A.
In:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 21, No. 1, 01.2006, p. 58-66.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Henriksen, K, Sørensen, MG, Nielsen, RH, Gram, J, Schaller, S
, Dziegiel, MH, Everts, V, Bollerslev, J & Karsdal, MA 2006, '
Degradation of the organic phase of bone by osteoclasts: a secondary role for lysosomal acidification',
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, vol. 21, no. 1, pp. 58-66.
https://doi.org/10.1359/JBMR.050905APA
Henriksen, K., Sørensen, M. G., Nielsen, R. H., Gram, J., Schaller, S.
, Dziegiel, M. H., Everts, V., Bollerslev, J., & Karsdal, M. A. (2006).
Degradation of the organic phase of bone by osteoclasts: a secondary role for lysosomal acidification.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
21(1), 58-66.
https://doi.org/10.1359/JBMR.050905Vancouver
Henriksen K, Sørensen MG, Nielsen RH, Gram J, Schaller S
, Dziegiel MH et al.
Degradation of the organic phase of bone by osteoclasts: a secondary role for lysosomal acidification.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2006 Jan;21(1):58-66.
https://doi.org/10.1359/JBMR.050905Author
Henriksen, Kim ; Sørensen, Mette G ; Nielsen, Rasmus H ; Gram, Jeppe ; Schaller, Sophie ; Dziegiel, Morten Hanefeld ; Everts, Vincent ; Bollerslev, Jens ; Karsdal, Morten A. / Degradation of the organic phase of bone by osteoclasts : a secondary role for lysosomal acidification. In: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2006 ; Vol. 21, No. 1. pp. 58-66.
Bibtex
@article{464fe2844935409c96ab55e6e6a44a01,
title = "Degradation of the organic phase of bone by osteoclasts: a secondary role for lysosomal acidification",
abstract = "Osteoclasts degrade bone matrix by secretion of hydrochloric acid and proteases. We studied the processes involved in the degradation of the organic matrix of bone in detail and found that lysosomal acidification is involved in this process and that MMPs are capable of degrading the organic matrix in the absence of cathepsin K.",
keywords = "Adult, Aged, Bone Resorption, Cathepsin K, Cathepsins, Cells, Cultured, Chloride Channels, Chromosome Disorders, Collagenases, Female, Humans, Male, Middle Aged, Osteoclasts, Osteoporosis, Vacuolar Proton-Translocating ATPases",
author = "Kim Henriksen and S{\o}rensen, {Mette G} and Nielsen, {Rasmus H} and Jeppe Gram and Sophie Schaller and Dziegiel, {Morten Hanefeld} and Vincent Everts and Jens Bollerslev and Karsdal, {Morten A}",
year = "2006",
month = jan,
doi = "10.1359/JBMR.050905",
language = "English",
volume = "21",
pages = "58--66",
journal = "Journal of Bone and Mineral Research",
issn = "0884-0431",
publisher = "Wiley-Blackwell",
number = "1",
}
RIS
TY - JOUR
T1 - Degradation of the organic phase of bone by osteoclasts
T2 - a secondary role for lysosomal acidification
AU - Henriksen, Kim
AU - Sørensen, Mette G
AU - Nielsen, Rasmus H
AU - Gram, Jeppe
AU - Schaller, Sophie
AU - Dziegiel, Morten Hanefeld
AU - Everts, Vincent
AU - Bollerslev, Jens
AU - Karsdal, Morten A
PY - 2006/1
Y1 - 2006/1
N2 - Osteoclasts degrade bone matrix by secretion of hydrochloric acid and proteases. We studied the processes involved in the degradation of the organic matrix of bone in detail and found that lysosomal acidification is involved in this process and that MMPs are capable of degrading the organic matrix in the absence of cathepsin K.
AB - Osteoclasts degrade bone matrix by secretion of hydrochloric acid and proteases. We studied the processes involved in the degradation of the organic matrix of bone in detail and found that lysosomal acidification is involved in this process and that MMPs are capable of degrading the organic matrix in the absence of cathepsin K.
KW - Adult
KW - Aged
KW - Bone Resorption
KW - Cathepsin K
KW - Cathepsins
KW - Cells, Cultured
KW - Chloride Channels
KW - Chromosome Disorders
KW - Collagenases
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Osteoclasts
KW - Osteoporosis
KW - Vacuolar Proton-Translocating ATPases
U2 - 10.1359/JBMR.050905
DO - 10.1359/JBMR.050905
M3 - Journal article
C2 - 16355274
VL - 21
SP - 58
EP - 66
JO - Journal of Bone and Mineral Research
JF - Journal of Bone and Mineral Research
SN - 0884-0431
IS - 1
ER -
