Degradation of the organic phase of bone by osteoclasts: a secondary role for lysosomal acidification
Research output: Contribution to journal › Journal article › Research › peer-review
Osteoclasts degrade bone matrix by secretion of hydrochloric acid and proteases. We studied the processes involved in the degradation of the organic matrix of bone in detail and found that lysosomal acidification is involved in this process and that MMPs are capable of degrading the organic matrix in the absence of cathepsin K.
| Original language | English |
|---|---|
| Journal | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research |
| Volume | 21 |
| Issue number | 1 |
| Pages (from-to) | 58-66 |
| Number of pages | 9 |
| ISSN | 0884-0431 |
| DOIs | |
| Publication status | Published - Jan 2006 |
- Adult, Aged, Bone Resorption, Cathepsin K, Cathepsins, Cells, Cultured, Chloride Channels, Chromosome Disorders, Collagenases, Female, Humans, Male, Middle Aged, Osteoclasts, Osteoporosis, Vacuolar Proton-Translocating ATPases
Research areas
ID: 47556731