Genetically determined serum levels of mannose-binding lectin correlate negatively with common carotid intima-media thickness in systemic lupus erythematosus

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Genetically determined serum levels of mannose-binding lectin correlate negatively with common carotid intima-media thickness in systemic lupus erythematosus. / Troelsen, Lone N; Garred, Peter; Christiansen, Buris; Torp-Pedersen, Christian; Jacobsen, Søren.

In: Journal of Rheumatology, Vol. 37, No. 9, 01.09.2010, p. 1815-21.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Troelsen, LN, Garred, P, Christiansen, B, Torp-Pedersen, C & Jacobsen, S 2010, 'Genetically determined serum levels of mannose-binding lectin correlate negatively with common carotid intima-media thickness in systemic lupus erythematosus', Journal of Rheumatology, vol. 37, no. 9, pp. 1815-21. https://doi.org/10.3899/jrheum.100158

APA

Troelsen, L. N., Garred, P., Christiansen, B., Torp-Pedersen, C., & Jacobsen, S. (2010). Genetically determined serum levels of mannose-binding lectin correlate negatively with common carotid intima-media thickness in systemic lupus erythematosus. Journal of Rheumatology, 37(9), 1815-21. https://doi.org/10.3899/jrheum.100158

Vancouver

Troelsen LN, Garred P, Christiansen B, Torp-Pedersen C, Jacobsen S. Genetically determined serum levels of mannose-binding lectin correlate negatively with common carotid intima-media thickness in systemic lupus erythematosus. Journal of Rheumatology. 2010 Sep 1;37(9):1815-21. https://doi.org/10.3899/jrheum.100158

Author

Troelsen, Lone N ; Garred, Peter ; Christiansen, Buris ; Torp-Pedersen, Christian ; Jacobsen, Søren. / Genetically determined serum levels of mannose-binding lectin correlate negatively with common carotid intima-media thickness in systemic lupus erythematosus. In: Journal of Rheumatology. 2010 ; Vol. 37, No. 9. pp. 1815-21.

Bibtex

@article{dc5d9038c9ec4178b534b892cbcac144,
title = "Genetically determined serum levels of mannose-binding lectin correlate negatively with common carotid intima-media thickness in systemic lupus erythematosus",
abstract = "Patients with systemic lupus erythematosus (SLE) have excess cardiovascular morbidity and mortality due to accelerated atherosclerosis that cannot be attributed to traditional cardiovascular risk factors alone. Variant alleles of the mannose-binding lectin gene (MBL2) causing low serum concentrations of functional mannose-binding lectin (MBL) are associated with SLE and development of atherosclerosis. Recent studies show that these variant alleles are associated with increased risk of arterial thrombosis and cardiovascular disease in patients with SLE. Intima-media thickness of the common carotid artery (ccIMT) is a validated noninvasive anatomic measure of subclinical atherosclerosis. In a cross-sectional study we examined the relation among ccIMT, MBL2 genotypes, and serum concentrations of MBL.",
author = "Troelsen, {Lone N} and Peter Garred and Buris Christiansen and Christian Torp-Pedersen and S{\o}ren Jacobsen",
year = "2010",
month = sep,
day = "1",
doi = "http://dx.doi.org/10.3899/jrheum.100158",
language = "English",
volume = "37",
pages = "1815--21",
journal = "Journal of Rheumatology",
issn = "0315-162X",
publisher = "Journal of Rheumatology Publishing Co. Ltd.",
number = "9",

}

RIS

TY - JOUR

T1 - Genetically determined serum levels of mannose-binding lectin correlate negatively with common carotid intima-media thickness in systemic lupus erythematosus

AU - Troelsen, Lone N

AU - Garred, Peter

AU - Christiansen, Buris

AU - Torp-Pedersen, Christian

AU - Jacobsen, Søren

PY - 2010/9/1

Y1 - 2010/9/1

N2 - Patients with systemic lupus erythematosus (SLE) have excess cardiovascular morbidity and mortality due to accelerated atherosclerosis that cannot be attributed to traditional cardiovascular risk factors alone. Variant alleles of the mannose-binding lectin gene (MBL2) causing low serum concentrations of functional mannose-binding lectin (MBL) are associated with SLE and development of atherosclerosis. Recent studies show that these variant alleles are associated with increased risk of arterial thrombosis and cardiovascular disease in patients with SLE. Intima-media thickness of the common carotid artery (ccIMT) is a validated noninvasive anatomic measure of subclinical atherosclerosis. In a cross-sectional study we examined the relation among ccIMT, MBL2 genotypes, and serum concentrations of MBL.

AB - Patients with systemic lupus erythematosus (SLE) have excess cardiovascular morbidity and mortality due to accelerated atherosclerosis that cannot be attributed to traditional cardiovascular risk factors alone. Variant alleles of the mannose-binding lectin gene (MBL2) causing low serum concentrations of functional mannose-binding lectin (MBL) are associated with SLE and development of atherosclerosis. Recent studies show that these variant alleles are associated with increased risk of arterial thrombosis and cardiovascular disease in patients with SLE. Intima-media thickness of the common carotid artery (ccIMT) is a validated noninvasive anatomic measure of subclinical atherosclerosis. In a cross-sectional study we examined the relation among ccIMT, MBL2 genotypes, and serum concentrations of MBL.

U2 - http://dx.doi.org/10.3899/jrheum.100158

DO - http://dx.doi.org/10.3899/jrheum.100158

M3 - Journal article

VL - 37

SP - 1815

EP - 1821

JO - Journal of Rheumatology

JF - Journal of Rheumatology

SN - 0315-162X

IS - 9

ER -

ID: 34077989