Genetically determined serum levels of mannose-binding lectin correlate negatively with common carotid intima-media thickness in systemic lupus erythematosus
Research output: Contribution to journal › Journal article › Research › peer-review
Patients with systemic lupus erythematosus (SLE) have excess cardiovascular morbidity and mortality due to accelerated atherosclerosis that cannot be attributed to traditional cardiovascular risk factors alone. Variant alleles of the mannose-binding lectin gene (MBL2) causing low serum concentrations of functional mannose-binding lectin (MBL) are associated with SLE and development of atherosclerosis. Recent studies show that these variant alleles are associated with increased risk of arterial thrombosis and cardiovascular disease in patients with SLE. Intima-media thickness of the common carotid artery (ccIMT) is a validated noninvasive anatomic measure of subclinical atherosclerosis. In a cross-sectional study we examined the relation among ccIMT, MBL2 genotypes, and serum concentrations of MBL.
Original language | English |
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Journal | Journal of Rheumatology |
Volume | 37 |
Issue number | 9 |
Pages (from-to) | 1815-21 |
Number of pages | 7 |
ISSN | 0315-162X |
DOIs | |
Publication status | Published - 1 Sep 2010 |
ID: 34077989