Filip Krag Knop
Clinical Professor
Department of Clinical Medicine
Borgmester Ib Juuls Vej 1, 2730 Herlev
Member of:
Internal Medicine: Endocrinology
- Published
Postprandial incretin and islet hormone responses and dipeptidyl-peptidase 4 enzymatic activity in patients with maturity onset diabetes of the young
Østoft, S. H., Bagger, J. I., Hansen, Torben, Hartmann, Bolette, Pedersen, Oluf Borbye, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 1 Aug 2015, In: European Journal of Endocrinology. 173, 2, p. 205-215 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A role for exogenous GLP-1 in the management of postprandial hypoglycaemia after Roux-en-Y gastric bypass?
Øhrstrøm, C. C. & Knop, Filip Krag, 2019, In: European Journal of Endocrinology. 181, 3, p. C5-C8Research output: Contribution to journal › Comment/debate › Research
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Clinical relevance of the bile acid receptor TGR5 in metabolism
van Nierop, F. S., Scheltema, M. J., Eggink, H. M., Pols, T. W., Sonne, David Peick, Knop, Filip Krag & Soeters, M. R., Mar 2017, In: The Lancet Diabetes and Endocrinology. 5, 3, p. 224–233Research output: Contribution to journal › Review › Research › peer-review
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INPP4B protects from metabolic syndrome and associated disorders
Zhang, M., Ceyhan, Y., Kaftanovskaya, E. M., Vasquez, J. L., Vacher, J., Knop, Filip Krag, Nathanson, L., Agoulnik, A. I., Ittmann, M. M. & Agoulnik, I. U., 2021, In: Communications Biology . 4, 1, 416.Research output: Contribution to journal › Journal article › Research › peer-review
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Prediabetes Defined by First Measured HbA1c Predicts Higher Cardiovascular Risk Compared With HbA1c in the Diabetes Range: A Cohort Study of Nationwide Registries
Yahyavi, S. K., Snorgaard, O., Knop, Filip Krag, Schou, Morten, Lee, C., Selmer, C., Gislason, Gunnar Hilmar, Torp-Pedersen, Christian, Blomberg Jensen, M. & Nissen Bonde, A., 2021, In: Diabetes Care. 44, 12, p. 2767-2774 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- E-pub ahead of print
Determinants of plasma levels of proglucagon and the metabolic impact of glucagon receptor signalling: a UK Biobank study
Winther-Sørensen, Marie, Garcia, S. L., Bartholdy, Andreas, Ottenheijm, Maud Eline, Banasik, Karina, Brunak, Søren, Sorensen, Charlotte Mehlin, Gluud, Lise Lotte, Knop, Filip Krag, Holst, Jens Juul, Rosenkilde, Mette, Jensen, Majken Karoline & Albrechtsen, Nicolai Jacob Wewer, 6 May 2024, (E-pub ahead of print) In: Diabetologia.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon acutely regulates hepatic amino acid catabolism and the effect may be disturbed by steatosis
Winther-Sørensen, M., Galsgaard, K. D., Santos, A., Trammell, S. A. J., Sulek, K., Kuhre, R. E., Pedersen, J., Andersen, D. B., Hassing, A. S., Dall, M., Treebak, J. T., Gillum, M. P., Torekov, S. S., Windeløv, J. A., Hunt, J. E., Kjeldsen, S. A. S., Jepsen, S. L., Vasilopoulou, C. G., Knop, F. K., Ørskov, C. & 7 others, , 2020, In: Molecular Metabolism. 42, 18 p., 101080.Research output: Contribution to journal › Journal article › Research › peer-review
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Hepatic steatosis and glucagon resistance develope in parallel resulting in hyperglucagonaemia and hyperaminoacidaemia
Winther-Sørensen, Marie, Galsgaard, Katrine Douglas, Santos, A., Pedersen, J., Hassing, Anna Skab, Dall, M., Treebak, Jonas Thue, Kjeldsen, Sasha Alexandra Sampson, Knop, Filip Krag, Werge, M. P., Eriksen, P. L., Vilstrup, H., Gluud, Lise Lotte, Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2020, In: Diabetologia. 63, SUPPL 1, p. S71-S72 142.Research output: Contribution to journal › Conference abstract in journal › Research
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The liver-alpha cell axis and type 2 diabetes
Albrechtsen, Nicolai Jacob Wewer, Pedersen, Jens, Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Suppli, M. P., Janah, L., Gromada, J., Vilstrup, H., Knop, Filip Krag & Holst, Jens Juul, 2019, In: Endocrine Reviews. 40, 5, p. 1353-1366Research output: Contribution to journal › Review › Research › peer-review
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Oxyntomodulin Identified as a Marker of Type 2 Diabetes and Gastric Bypass Surgery by Mass-spectrometry Based Profiling of Human Plasma
Albrechtsen, Nicolai Jacob Wewer, Hornburg, D., Albrechtsen, Reidar, Svendsen, B., Toräng, S., Jepsen, Sara Lind, Kuhre, Rune Ehrenreich, Hansen, M., Janus, C., Floyd, A., Lund, Asger Bach, Vilsbøll, Tina, Knop, Filip Krag, drb459, drb459, Deacon, Carolyn F., Meissner, F., Mann, Matthias, Holst, Jens Juul & Hartmann, Bolette, May 2016, In: EBioMedicine. 7, p. 112-120 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inability of Some Commercial Assays to Measure Suppression of Glucagon Secretion
Albrechtsen, Nicolai Jacob Wewer, Veedfald, Simon, Plamboeck, A., Deacon, Carolyn F., Hartmann, Bolette, Knop, Filip Krag, Vilsbøll, Tina & Holst, Jens Juul, 2016, In: Journal of Diabetes Research. 2016, 5 p., 8352957.Research output: Contribution to journal › Journal article › Research › peer-review
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The biology of glucagon and the consequences of hyperglucagonemia
Albrechtsen, Nicolai Jacob Wewer, Kuhre, Rune Ehrenreich, Pedersen, Jens, Knop, Filip Krag & Holst, Jens Juul, 9 Sep 2016, In: Biomarkers in Medicine. 10, 11, p. 1141-1151 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Evidence of a liver-alpha cell axis in humans: hepatic insulin resistance attenuates relationship between fasting plasma glucagon and glucagonotropic amino acids
Albrechtsen, Nicolai Jacob Wewer, Færch, K., Jensen, T. M., Witte, D. R., Pedersen, Jens, Mahendran, Y., Jonsson, Anna Elisabet, Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Torekov, Signe Sørensen, Lauritzen, T., Pedersen, Oluf Borbye, Knop, Filip Krag, Hansen, Torben, Jørgensen, M. E., Vistisen, D. & Holst, Jens Juul, 2018, In: Diabetologia. 61, 3, p. 671-680Research output: Contribution to journal › Journal article › Research › peer-review
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100 years of glucagon and 100 more
Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Cherrington, A. D., Finan, B., Gluud, Lise Lotte, Dean, E. D., Campbell, J. E., Bloom, S. R., Tan, T. M., Knop, Filip Krag & Müller, T. D., 2023, In: Diabetologia. 66, p. 1378–1394Research output: Contribution to journal › Review › Research › peer-review
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Hyperglucagonemia correlates with plasma levels of non-branched-chain amino acids in patients with liver disease independent of type 2 diabetes
Albrechtsen, Nicolai Jacob Wewer, Junker, A. E., Christensen, M., Hædersdal, S., Wibrand, F., Lund, A. M., Galsgaard, Katrine Douglas, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2018, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 314, 1, p. G91-G96Research output: Contribution to journal › Journal article › Research › peer-review
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A sandwich ELISA for measurement of the primary glucagon-like peptide-1 metabolite
Albrechtsen, Nicolai Jacob Wewer, Asmar, A., Jensen, F., Törang, S., Simonsen, L., Kuhre, Rune Ehrenreich, Asmar, M., Veedfald, Simon, Plamboeck, A., Knop, Filip Krag, Vilsbøll, Tina, Madsbad, Sten, Nauck, M. A., Deacon, Carolyn F., Bülow, J., Holst, Jens Juul & Hartmann, Bolette, 1 Sep 2017, In: American Journal of Physiology: Endocrinology and Metabolism. 313, 3, p. E284-E291Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity
Vrieze, A., Out, C., Fuentes, S., Jonker, L., Reuling, I., Kootte, R. S., van Nood, E., Holleman, F., Knaapen, M., Romijn, J. A., Soeters, M. R., Blaak, E. E., Dallinga-Thie, G. M., Reijnders, D., Ackermans, M. T., Serlie, M. J., Knop, F. K., Holst, J. J., van der Ley, C., Kema, I. P. & 6 others, , Apr 2014, In: Journal of Hepatology. 60, 4, p. 824-31 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon-like peptide-1 and diabetes treatment
Vilsbøll, Tina, Hare, K., Bagger, J. O. & Knop, Filip Krag, 2009, In: International Diabetes Monitor. 21, p. 1-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Incretin hormones and diabetes mellitus
Vilsbøll, Tina, Knop, Filip Krag, Deacon, Carolyn F. & Holst, Jens Juul, 2009, Therapeutic Strategies in Diabetes. Stehouwer, C. D. A. & Schaper, N. (eds.). Oxford: Clinical Publishing, p. 99-114Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
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Long-acting GLP-1 analogs for the treatment of type 2 diabetes mellitus
Vilsbøll, Tina & Knop, Filip Krag, 1 Jan 2008, In: BioDrugs. 22, 4, p. 251-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The spectrum of antidiabetic actions of GLP-1 in patients with diabetes
Vilsbøll, Tina, Holst, Jens Juul & Knop, Filip Krag, 2009, In: Best Practice & Research: Clinical Endocrinology & Metabolism. 23, 4, p. 453-62 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Betydningen af inkretinhormonerne glucose-dependent insulinotropic peptide og glucagon-like peptide-1 for patogenesen ved type 2-diabetes mellitus
Vilsbøll, Tina & Knop, Filip Krag, 28 May 2007, In: Ugeskrift for Laeger. 169, 22, p. 2101-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of glucagon-like peptide-1 receptor agonists on weight loss: systematic review and meta-analyses of randomised controlled trials
Vilsbøll, Tina, Christensen, M., Junker, A. E., Knop, Filip Krag & Gluud, C. N., 2012, In: B M J (Clinical Research Edition). 344, p. d7771Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The pathophysiology of diabetes involves a defective amplification of the late-phase insulin response to glucose by glucose-dependent insulinotropic polypeptide-regardless of etiology and phenotype
Vilsbøll, Tina, Knop, Filip Krag, Krarup, T., Johansen, A., Madsbad, Sten, Larsen, S., Hansen, T., Pedersen, O., Holst, J. M. & Johansen, A., 1 Oct 2003, In: Journal of Clinical Endocrinology and Metabolism. 88, 10, p. 4897-903 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
THERAPY Liraglutide: preventing or postponing T2DM diagnosis?
Vilsbøll, Tina & Knop, Filip Krag, 2017, In: Nature Reviews Endocrinology. 13, p. 320-322Research output: Contribution to journal › Comment/debate › Research › peer-review
ID: 40100368
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439
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L-cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling
Research output: Contribution to journal › Journal article › Research › peer-review
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372
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Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease
Research output: Contribution to journal › Journal article › Research › peer-review
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303
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Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production
Research output: Contribution to journal › Journal article › Research › peer-review
Published