Flemming Pociot

Flemming Pociot

Clinical Professor

Member of:

  • Internal Medicine: Endocrinology


  1. 2015
  2. Published

    Residual β-cell function and the insulin-like growth factor system in Danish children and adolescents with type 1 diabetes

    Sorensen, J. S., Birkebaek, N. H., Bjerre, M., Pociot, Flemming, Kristensen, K., Hoejberg, A. S., Frystyk, J. & Danish Society for Diabetes in Childhood and Adolescence, D. S. F. D. I. C. A. A., Mar 2015, In: The Journal of Clinical Endocrinology & Metabolism. 100, 3, p. 1053-61 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Alu Elements as Novel Regulators of Gene Expression in Type 1 Diabetes Susceptibility Genes?

    Kaur, S. & Pociot, Flemming, 2015, In: Genes. 6, 3, p. 577-91 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Transcriptomic landscape of lncRNAs in inflammatory bowel disease

    Mirza, A. H., Bang-Berthelsen, C. H., Seemann, Ernst Stefan, Pan, X., Frederiksen, K. S., Vilien, M., Gorodkin, Jan & Pociot, Flemming, 2015, In: Genome Medicine. 7, 22 p., 39.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. 2014
  6. Published

    Systemic levels of CCL2, CCL3, CCL4 and CXCL8 differ according to age, time period and season among children newly diagnosed with type 1 diabetes and their healthy siblings

    Thorsen, S. U., Eising, S., Mortensen, H. B., Skogstrand, K., Pociot, Flemming, Johannesen, Jesper, Svensson, Jannet & Danish Childhood Diabetes Registry, D. C. D. R., Dec 2014, In: Scandinavian Journal of Immunology. 80, 6, p. 452-461 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    No association between type 1 diabetes and genetic variation in vitamin D metabolism genes: a Danish study

    Thorsen, S. U., Mortensen, H. B., Carstensen, Bendix, Fenger, M., Thuesen, B. H., Husemoen, L., Bergholdt, R., Brorsson, C., Pociot, Flemming, Linneberg, Allan René & Svensson, Jannet, Sep 2014, In: Pediatric Diabetes. 15, 6, p. 416-421 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients

    Fløyel, T., Brorsson, C., Nielsen, L. B., Miani, M., Bang-Berthelsen, C. H., Friedrichsen, M., Overgaard, A. J., Berchtold, L. A., Wiberg, A., Poulsen, P., Hansen, L., Rosinger, S., Boehm, B. O., Ram, R., Nguyen, Q., Mehta, M., Morahan, G., Concannon, P., Bergholdt, R., Nielsen, J. H. & 7 others, Reinheckel, T., von Herrath, M., Vaag, Allan, Eizirik, D. L., Mortensen, H. B., Størling, J. & Pociot, Flemming, 15 Jul 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 28, p. 10305-10310 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Spatially conserved regulatory elements identified within human and mouse Cd247 gene using high-throughput sequencing data from the ENCODE project.

    Pundhir, Sachin, Hannibal, T. D., Bang-Berthelsen, C. H., Wegener, A. K., Pociot, Flemming, Holmberg, D. I. & Gorodkin, Jan, 2 May 2014, In: Gene. 545, 1, p. 80-87 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Circulating MicroRNAs in Plasma of Hepatitis B e Antigen Positive Children Reveal Liver-Specific Target Genes

    Winther, T. N., Jacobsen, K. S., Mirza, A. H., Heiberg, I. L., Bang-Berthelsen, C. H., Pociot, Flemming & Høgh, Birthe, 2014, In: International Journal of Hepatology. 2014, p. 791045

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Genetic versus Non-Genetic Regulation of miR-103, miR-143 and miR-483-3p Expression in Adipose Tissue and Their Metabolic Implications-A Twin Study

    Bork-Jensen, J., Thuesen, A. C. B., Bang-Bertelsen, C. H., Grunnet, Louise Groth, Pociot, Flemming, Beck-Nielsen, H., Ozanne, S. E., Poulsen, P. & Vaag, A., 2014, In: Genes. 5, 3, p. 508-17 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. 2013
  13. Published

    Differential plasma microRNA profiles in HBeAg positive and HBeAg negative children with chronic hepatitis B

    Winther, T. N., Bang-Berthelsen, C. H., Heiberg, I. L., Pociot, Flemming & Høgh, Birthe, 2013, In: PLOS ONE. 8, 3, p. e58236

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Hepatitis B surface antigen quantity positively correlates with plasma levels of microRNAs differentially expressed in immunological phases of chronic hepatitis B in children

    Winther, T. N., Heiberg, I. L., Bang-Berthelsen, C. H., Pociot, Flemming & Høgh, Birthe, 2013, In: PLoS ONE. 8, 11, p. e80384

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    No difference in vitamin d levels between children newly diagnosed with type 1 diabetes and their healthy siblings

    Thorsen, S. U., Mortensen, H. B., Carstensen, Bendix, Fenger, M., Thuesen, B. H., Husemoen, L. L., Bergholdt, R., Brorsson, C., Pociot, Flemming, Linneberg, Allan René & Svensson, Jannet, 2013, In: Diabetes Care. 36, 9, p. e157-e158

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Selenium supplementation for patients with Graves’ hyperthyroidism (the GRASS trial): study protocol for a randomized controlled trial

    Watt, Torquil, Cramon, P., Bjorner, J. B., Bonnema, S. J., Feldt-Rasmussen, Ulla, Gluud, C., Gram, J., Hansen, J. L., Hegedüs, L., Knudsen, Nils Jakob, Bach-Mortensen, P., Nolsöe, R., Nygaard, Birte, Pociot, Flemming, Skoog, M., Winkel, P. & Rasmussen, A. K., 2013, In: Trials. 14, April , p. 1-10 10 p., 119.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. 2012
  18. Published

    TiSH--a robust and sensitive global phosphoproteomics strategy employing a combination of TiO2, SIMAC, and HILIC

    Engholm-Keller, K., Birck, P., Størling, Joachim, Pociot, Flemming, Mandrup-Poulsen, Thomas & Larsen, M. R., 22 Oct 2012, In: International Journal of Proteomics. 75, 18, p. 5749-61 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic ß cell fate in response to cytokines

    Hansen, J. B., Tonnesen, M. F., Madsen, A. N., Hagedorn, P., Friberg, J., Grunnet, L. G., Heller, R. S., Nielsen, A. Ø., Størling, J., Baeyens, L., Anker-Kitai, L., Qvortrup, K., Bouwens, L., Efrat, S., Aalund, M., Andrews, N. C., Billestrup, N., Karlsen, A. E., Holst, B., Pociot, F. & 1 others, Mandrup-Poulsen, Thomas, 2012, In: Cell Metabolism. 16, 4, p. 449-61 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. 2011
  21. Published

    Relationship between ZnT8Ab, the SLC30A8 gene and disease progression in children with newly diagnosed type 1 diabetes

    Nielsen, L. B., Vaziri-Sani, F., Pörksen, S., Andersen, Marie Louise Charlotte M, Svensson, J., Bergholdt, R., Pociot, Flemming, Hougaard, P., de Beaufort, C., Castaño, L., Mortensen, H. B., Lernmark, A., Hansen, L. & Hvidoere Study Group On Childhood Diabetes, H. S. G. O. C. D., Dec 2011, In: Autoimmunity Highlights. 44, 8, p. 616-23 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Hypoglycemia, S-ACE and ACE genotypes in a Danish nationwide population of children and adolescents with type 1 diabetes

    Johannesen, Jesper, Svensson, Jannet, Bergholdt, R., Eising, S., Gramstrup, H., Frandsen, E., Dick-Nielsen, J., Hansen, L., Pociot, Flemming, Mortensen, H. B. & Danish Society for Diabetes in Childhood and Adolescence, D. S. F. D. I. C. A. A., Mar 2011, In: Pediatric Diabetes Online. 12, 2, p. 100-6 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    A possible association between a dysfunctional skin barrier (filaggrin null-mutation status) and diabetes: a cross-sectional study

    Thyssen, Jacob Pontoppidan, Linneberg, Allan René, Carlsen, B. C., Johansen, Jeanne Duus, Engkilde, K., Hansen, Torben, Pociot, Flemming, Pedersen, Oluf Borbye, Meldgaard, M., Szecsi, P. B., Stender, Steen & Menné, T., 1 Jan 2011, In: BMJ Open. 1, 1, p. e000062 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and beta-cell apoptosis

    Berchtold, L. A., Størling, Z. M., Ortis, F., Lage, K., Bang-Berthelsen, C., Bergholdt, R., Hald, J., Brorsson, C. A., Eizirik, D. L., Pociot, Flemming, Brunak, Søren & Størling, Joachim, 2011, In: PNAS Early Edition. 108, 37, p. E681-8

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. 2010
  26. Published

    Finding diabetic nephropathy biomarkers in the plasma peptidome by high-throughput magnetic bead processing and MALDI-TOF-MS analysis

    Hansen, H. G., Overgaard, J., Lajer, M., Hubalek, F., Højrup, P., Pedersen, L., Tarnow, L., Rossing, Peter, Pociot, Flemming & McGuire, J. N., 1 Sep 2010, In: Proteomics - Clinical Applications. 4, 8-9, p. 697-705 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Further evidence that mutations in INS can be a rare cause of Maturity-Onset Diabetes of the Young (MODY)

    Boesgaard, T. W., Pruhova, S., Andersson, E. A., Cinek, O., Obermannova, B., Lauenborg, J., Damm, Peter, Bergholdt, R., Pociot, Flemming, Pisinger, C., Barbetti, F., Lebl, J., Pedersen, Oluf Borbye & Hansen, Torben, 1 Jan 2010, In: B M C Medical Genetics. 11, p. 42

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Plasma proteome analysis of patients with type 1 diabetes with diabetic nephropathy

    Overgaard, A. J., Hansen, H. G., Lajer, M., Pedersen, L., Tarnow, L., Rossing, Peter, McGuire, J. N. & Pociot, Flemming, 2010, In: Proteome Science. 8, p. 4 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. 2009
  30. Published

    Identification of T1D susceptibility genes within the MHC region by combining protein interaction networks and SNP genotyping data

    Brorsson, C., Hansen, N. T., Lage, K., Bergholdt, R., Brunak, Søren, Pociot, Flemming & Diabetes Genetics Consortium, D. G. C., Feb 2009, In: Diabetes, Obesity and Metabolism Online. 11, SUPPL. 1, p. 60-6 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Expression profiling of human genetic and protein interaction networks in type 1 diabetes

    Bergholdt, R., Brorsson, C., Lage, K., Nielsen, Jens Høiriis, Brunak, S. & Pociot, Flemming, 2009, In: PLoS ONE. 4, 7, p. e6250

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Functional SOCS1 polymorphisms are associated with variation in obesity in whites

    Gylvin, T., Ek, J., Nolsøe, R., Albrechtsen, A., Andersen, G., Bergholdt, R., Brorsson, C., Bang-Berthelsen, C. H., Hansen, T., Karlsen, A. E., Billestrup, N., Borch-Johnsen, K., Jørgensen, T., Pedersen, Oluf Borbye, Mandrup-Poulsen, Thomas, Nerup, J. & Pociot, Flemming, 2009, In: Diabetes, Obesity and Metabolism. 11, 3, p. 196-203 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

    Barrett, J. C., Clayton, D. G., Concannon, P., Akolkar, B., Cooper, J. D., Erlich, H. A., Julier, C., Morahan, G., Nerup, J., Nierras, C., Plagnol, V., Pociot, Flemming, Schuilenburg, H., Smyth, D. J., Stevens, H., Todd, J. A., Walker, N. M., Rich, S. S. & The Type 1 Diabetes Genetics Consortium, T. T. 1. D. G. C., 2009, In: Nature Genetics.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the type 1 diabetes genetics consortium

    Concannon, P., Chen, W. M., Julier, C., Morahan, G., Akolkar, B., Erlich, H. A., Hilner, J. E., Nerup, J., Nierras, C., Pociot, Flemming, Todd, J. A. & Rich, S. S., 2009, In: Diabetes. 58, 4, p. 1018-1022 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    No association of the IRS1 and PAX4 genes with type I diabetes

    Bergholdt, R., Brorsson, C., Boehm, B., Morahan, G. & Pociot, Flemming, 2009, In: Genes and Immunity. 10, p. S49-S53 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Reproducible association with type 1 diabetes in the extended class I region of the major histocompatibility complex

    Viken, M. K., Blomhoff, A., Olsson, M., Akselsen, H. E., Pociot, Flemming, Nerup, J., Kockum, I., Cambon-Thomsen, A., Thorsby, E., Undlien, D. E. & Lie, B. A., 2009, In: Genes and Immunity. 10, 4, p. 323-333 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Results of the MHC fine mapping workshop

    Rich, S. S., Akolkar, B., Concannon, P., Erlich, H., Hilner, J., Julier, C., Morahan, G., Nerup, J., Nierras, C., Pociot, Flemming & Todd, J. A., 2009, In: Diabetes, Obesity and Metabolism. 11, SUPPL. 1, p. 108-109 1 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Zinc transporter gene expression is regulated by pro-inflammatory cytokines: A potential role for zinc transporters in beta-cell apoptosis?

    Egefjord, L., Jensen, J. L., Bang-Berthelsen, C. H., Petersen, A. B., Smidt, K., Schmitz, O., Karlsen, A. E., Pociot, Flemming, Chimienti, F., Rungby, J. & Magnusson, N. E., 2009, In: BMC Endocrine Disorders. 9

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. 2008
  40. Published

    A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3

    Concannon, P., Onengut-Gumuscu, S., Todd, J. A., Smyth, D. J., Pociot, Flemming, Bergholdt, R., Akolkar, B., Erlich, H. A., Hilner, J. E., Julier, C., Morahan, G., Nerup, J., Nierras, C. R., Chen, W. M. & Rich, S. S., 2008, In: Diabetes. 57, 10, p. 2858-2861 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population

    Brorsson, C., Bergholdt, R., Sjogren, M., Eising, S., Sorensen, K. M., Hougaard, D. M., Orho-Melander, M., Groop, L. & Pociot, Flemming, 2008, In: Molecular Genetics and Metabolism. 94, 3, p. 386-388 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Mass spectrometry is only one piece of the puzzle in clinical proteomics

    McGuire, J. N., Overgaard, J. & Pociot, Flemming, 2008, In: Briefings in Functional Genomics and Proteomics. 7, 1, p. 74-83 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    The Faroese, a genetic isolate with a strong founder effect, allows the identification of Type 1 diabetes susceptibility regions

    Nolsoe, R., Roin, J., Deckert, M., Bergholdt, R., Kelly, J., Brorsson, C., Harley, J., Olsen, S., Pociot, Flemming & Mandrup-Poulsen, Thomas, 2008, In: Clinical Immunology. 127, Suppl. S, p. S105-S105

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Variation within the PPARG gene is associated with residual beta-cell function and glycemic control in children and adolescents during the first year of clinical type 1 diabetes

    Porksen, S., Nielsen, L. B., Mortensen, H. B., Danne, T., Kocova, M., Castano, L., Pociot, Flemming, Hougaard, P., Ekstrom, C. T., Gammeltoft, S., Knip, M. & Hansen, L., 2008, In: Pediatric Diabetes Online. 9, 4, p. 297-302 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. 2007
  46. Published

    A human phenome-interactome network of protein complexes implicated in genetic disorders

    Lage, K., Karlberg, E. O., Størling, Z. M., Olason, P. I., Pedersen, A. G., Rigina, O., Hinsby, A. M., Tümer, Asuman Zeynep, Pociot, Flemming, Tommerup, Niels, Moreau, Y. & Brunak, S., 2007, In: Nature Biotechnology. 25, 3, p. 309-16 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Integrative analysis for finding genes and networks involved in diabetes and other complex diseases

    Bergholdt, R., Størling, Z. M., Lage, K., Karlberg, E. O., Olason, P. I., Aalund, M., Nerup, J., Brunak, Søren, Workman, C. & Pociot, Flemming, 2007, In: Genome Biology (Online Edition). 8, 11, p. R253

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Transcriptional profiling of type 1 diabetes genes on chromosome 21 in a rat beta-cell line and human pancreatic islets

    Bergholdt, R., Karlsen, A. E., Hagedorn, P. H., Aalund, M., Nielsen, Jens Høiriis, Kruhoffer, M., Orntoft, T., Wang, H., Wollheim, C. B., Nerup, J. & Pociot, Flemming, 2007, In: Genes and Immunity. 8, 3, p. 232-238 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Ætiologi og patogenese, Type 1

    Bergholdt, R., Larsen, C. M., Pociot, Flemming, Mandrup-Poulsen, Thomas, Hilsted, J. C., Christensen, J. S. & Borch-Johnsen, K., 2007, Diabetes. 1 ed. København: Handelshøjskolens Forlag, Vol. 6. p. -

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  50. 2005
  51. Published

    Functional promoter haplotypes of the human FAS gene are associated with the phenotype of SLE characterized by thrombocytopenia

    Nolsøe, R. L., Kelly, J. A., Pociot, Flemming, Moser, K., Kristiansen, O. P., Mandrup-Poulsen, Thomas & Harley, J. B., 1 Dec 2005, In: Genes and Immunity. 6, 8, p. 699-706 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. 2004
  53. Published

    Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways

    Karlsen, A. E., Heding, P. E., Frobøse, H., Rønn, S. G., Kruhøffer, M., Orntoft, T. F., Darville, M., Eizirik, D. L., Pociot, Flemming, Nerup, J., Mandrup-Poulsen, Thomas & Billestrup, Nils, 1 Nov 2004, In: Diabetologia. 47, 11, p. 1998-2011 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity

    Gylvin, T., Nolsøe, R., Hansen, Torben, Nielsen, E. M. D., Bergholdt, R., Karlsen, A. E., Billestrup, Nils, Borch-Johnsen, K., Pedersen, O., Mandrup-Poulsen, Thomas, Nerup, J. & Pociot, Flemming, 1 Jul 2004, In: Diabetologia. 47, 7, p. 1273-7 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Identification of a type 1 diabetes-associated CD4 promoter haplotype with high constitutive activity

    Kristiansen, O. P., Karlsen, A. E., Larsen, Z. M., Johannesen, Jesper, Pociot, Flemming, Mandrup-Poulsen, Thomas & Danish IDDM Epidemiology and Genetics Group and Danish Study Group of IDDM in Childhood, D. I. E. A. G. G. A. D. S. G. O. I. I. C., 1 Jun 2004, In: Scandinavian Journal of Immunology. 59, 6, p. 582-91 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Type 1 database mellitus: an inflammatory disease of the islet.

    Bergholdt, R., Heding, P., Nielsen, K., Nolsøe, R., Sparre, T., Størling, J., Nerup, J., Pociot, Flemming & Mandrup-Poulsen, Thomas, 2004, In: Advances in Experimental Medicine and Biology. 552, p. 129-53 24 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. 2003
  58. Published

    Association of a functional 17beta-estradiol sensitive IL6-174G/C promoter polymorphism with early-onset type 1 diabetes in females

    Kristiansen, O. P., Nolsøe, R. L., Larsen, L., Gjesing, A. M. P., Johannesen, J., Larsen, Z. M. E., Lykkesfeldt, A. E., Karlsen, A. E., Pociot, Flemming, Mandrup-Poulsen, Thomas & DIEGG, D., 15 May 2003, In: Human Molecular Genetics. 12, 10, p. 1101-10 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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