Leif Breum

Leif Breum

Clinical Associate Professor

Member of:

  • Internal Medicine: Endocrinology


Publication year:
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1 - 22 out of 22Page size: 25
  1. 2023
  2. Published

    Quality of life, patient satisfaction, and cardiovascular outcomes of the randomised 2 x 3 factorial Copenhagen insulin and Metformin therapy (CIMT) trial – A detailed statistical analysis plan

    Olsen, M. H., Almdal, Thomas Peter, Madsbad, Sten, Ovesen, C., Gluud, C., Sneppen, S. B., Breum, Leif, Hedetoft, C., Krarup, T., Lundby-Christensen, L., Mathiesen, Elisabeth, Røder, M. E., drb459, drb459, Wiinberg, N. & Jakobsen, J. C., 2023, In: Contemporary Clinical Trials Communications. 33, 101095.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. 2022
  4. Published

    Effects of 18-months metformin versus placebo in combination with three insulin regimens on RNA and DNA oxidation in individuals with type 2 diabetes: A post-hoc analysis of a randomized clinical trial

    Larsen, E. L., Kjær, L. K., Lundby-Christensen, L., Boesgaard, T. W., Breum, Leif, Gluud, C., Hedetoft, C., Krarup, T., Lund, S. S., Mathiesen, Elisabeth, Perrild, Hans, Sneppen, S. B., Tarnow, L., Thorsteinsson, B., drb459, drb459, Poulsen, Henrik Enghusen, Madsbad, Sten & Almdal, Thomas Peter, 2022, In: Free Radical Biology and Medicine. 178, p. 18-25 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. 2021
  6. Published

    Effect of metformin and insulin vs. placebo and insulin on whole body composition in overweight patients with type 2 diabetes: a randomized placebo-controlled trial

    Nordklint, A. K., Almdal, Thomas Peter, Vestergaard, P., Lundby-Christensen, L., Boesgaard, T. W., Breum, Leif, Gade-Rasmussen, B., Sneppen, S. B., Gluud, C., Hemmingsen, B., Perrild, Hans, Madsbad, Sten, Mathiesen, Elisabeth, Tarnow, L., Thorsteinsson, B., drb459, drb459, Lund, S. S. & Eiken, P., 2021, In: Osteoporosis International. 32, p. 1837–1848

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. 2020
  8. Published

    Prediction of carotid intima-media thickness and its relation to cardiovascular events in persons with type 2 diabetes

    Winckler, K., Thorsteinsson, B., Wiinberg, N., Jensen, Andreas Kryger, Lundby-Christensen, L., Heitmann, Berit, Lund, S. S., Krarup, T., Jensen, T., Vestergaard, H., Breum, Leif, Sneppen, S., Boesgaard, T., Madsbad, Sten, Gluud, C., Vaag, A., Almdal, Thomas Peter, Tarnow, L. & The CIMT trial group, T. C. T. G., Oct 2020, In: Journal of Diabetes and its Complications. 34, 10, 107681.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Effect of Metformin vs. Placebo in Combination with Insulin Analogues on Bone Markers P1NP and CTX in Patients with Type 2 Diabetes Mellitus

    Nordklint, A. K., Almdal, Thomas Peter, Vestergaard, P., Lundby-Christensen, L., Jørgensen, Niklas Rye, Boesgaard, T. W., Breum, Leif, Gade-Rasmussen, B., Sneppen, S. B., Gluud, C., Hemmingsen, B., Krarup, T., Madsbad, Sten, Mathiesen, Elisabeth, Perrild, Hans, Tarnow, L., Thorsteinsson, B., Vestergaard, H., Lund, S. S. & Eiken, P., 2020, In: Calcified Tissue International. 107, 2, p. 160-169 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. 2018
  11. Published

    The effect of metformin versus placebo in combination with insulin analogues on bone mineral density and trabecular bone score in patients with type 2 diabetes mellitus: a randomized placebo-controlled trial

    Nordklint, A. K., Almdal, Thomas Peter, Vestergaard, P., Lundby-Christensen, L., Boesgaard, T. W., Breum, Leif, Gade-Rasmussen, B., Sneppen, S. B., Gluud, C., Hemmingsen, B., Jensen, T., Krarup, T., Madsbad, Sten, Mathiesen, Elisabeth, Perrild, Hans, Tarnow, L., Thorsteinsson, B., drb459, drb459, Lund, S. S. & Eiken, P., 2018, In: Osteoporosis International. 29, 11, p. 2517-2526

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. 2016
  13. Published

    Search for supersymmetry at root s=13 TeV in final states with jets and two same-sign leptons or three leptons with the ATLAS detector

    Aad, G., Abbott, B., Abdallah, J., Abdinov, O., Abeloos, B., Aben, R., Abolins, M., AbouZeid, O. S., Abramowicz, H., Abreu, H., Breum, L., Abreu, R., Adye, T., Dam, M., Hansen, J. D., Hansen, J. B., Xella, S., Hansen, P. H., Petersen, T. C., Thomsen, L. A. & 7 others, Pingel, A. M., Løvschall-Jensen, A. E., Alonso Diaz, A., Monk, J. W., Pedersen, L. E., Wiglesworth, Graig & Galster, G. A. G. K., 7 May 2016, In: European Physical Journal C. 76, 5, 259.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Effects of biphasic, basal-bolus or basal insulin analogue treatments on carotid intima-media thickness in patients with type 2 diabetes mellitus: the randomised Copenhagen Insulin and Metformin Therapy (CIMT) trial

    Lundby-Christensen, L., Vaag, A., Tarnow, L., Almdal, T. P., Lund, S. S., Wetterslev, J., Gluud, C., Boesgaard, T. W., Wiinberg, N., Perrild, H., Krarup, T., Snorgaard, O., Gade-Rasmussen, B., Thorsteinsson, B., Røder, M., Mathiesen, E. R., Jensen, T., Vestergaard, H., Hedetoft, C., Breum, L. & 6 others, Duun, E., Sneppen, S. B., Pedersen, Oluf Borbye, Hemmingsen, B., Carstensen, Bendix & Madsbad, Sten, 2016, In: B M J Open. 6, 2, e008377.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Metformin versus placebo in combination with insulin analogues in patients with type 2 diabetes mellitus: the randomised, blinded Copenhagen Insulin and Metformin Therapy (CIMT) trial

    Lundby-Christensen, L., Tarnow, L., Boesgaard, T. W., Lund, S. S., Wiinberg, N., Perrild, H., Krarup, T., Snorgaard, O., Gade-Rasmussen, B., Thorsteinsson, B., Røder, M., Mathiesen, E. R., Jensen, T., Vestergaard, H., Hedetoft, C., Breum, L., Duun, E., Sneppen, S. B., Pedersen, O., Hemmingsen, B. & 6 others, Carstensen, Bendix, Madsbad, Sten, Gluud, C., Wetterslev, J., Vaag, Allan & Almdal, Thomas Peter, 2016, In: B M J Open. 6, 2, e008376.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. 2013
  17. Published

    Under-reporting of adverse effects of tesofensine

    Astrup, A., Madsbad, Sten, Breum, Leif, Jensen, T. J., Kroustrup, J. P. & Larsen, T. M., 2013, In: Lancet. 382, 9887, p. 127 1 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  18. 2012
  19. Published

    Bilateral primary adrenal lymphoma presenting with adrenal insufficiency

    Holm, J., Breum, Leif, Stenfeldt, K. & Hitz, Mette Friberg, 2012, In: Case Reports in Endocrinology. 2012, p. 638298

    Research output: Contribution to journal › Journal article › Research

  20. 2009
  21. Published

    Effekt af tesofensine på kropsvægt og kropssammensætning hos svært overvægtige

    Nielsen, A. H., Larsen, T. M., Madsbad, Sten, Breum, Leif, Jensen, T. J., Kroustrup, J. P. & Astrup, A., 2009, In: Ugeskrift for læger. 171, 41-42, p. 2974-2977 4 p.

    Research output: Contribution to journal › Journal article › Research

  22. Published

    Study rationale and design of the CIMT trial: the Copenhagen Insulin and Metformin Therapy trial

    Lundby Christensen, L., Almdal, T., Boesgaard, T., Breum, L., Dunn, E., Gade-Rasmussen, B., Gluud, C., Hedetoft, C., Jarloev, A., Jensen, T., Krarup, T., Johansen, L. B., Lund, S. S., Madsbad, S., Mathiesen, E., Moelvig, J., Nielsen, F., Perrild, H., Pedersen, O., Roeder, M. & 31 others, Snorgaard, O., Tarnow, L., Thorsteinsson, B., Vaag, Allan, drb459, drb459, Wetterslev, J., Wiinberg, N., CIMT Trial Group, C. T. G., Lundby Christensen, L., Almdal, T., Boesgaard, T., Breum, L., Dunn, E., Gade-Rasmussen, B., Gluud, C., Hedetoft, C., Jarloev, A., Jensen, T., Krarup, T., Johansen, L. B., Lund, S. S., Madsbad, Sten, Mathiesen, E., Moelvig, J., Nielsen, F., Perrild, Hans, Pedersen, O., Roeder, M., Snorgaard, O., Thorsteinsson, B. & drb459, drb459, 2009, In: Diabetes, Obesity and Metabolism. 11, 4, p. 315-22 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    The effect of tesofensine on weight loss: results from a one-armed, open-labelled extension study

    Astrup, A., Madsbad, Sten, Breum, Leif, Kroustrup, J. P., Raben, A., Jensen, J. K. S., Meier, D. & Sjödin, Anders Mikael, 2009, In: Obesity Facts. suppl. 2, p. 211-212 2 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

  24. Published

    The long-term effect of tesofensine on weight loss: interim results from a one-armed, open-labelled extension study

    Sjödin, Anders Mikael, Madsbad, Sten, Breum, Leif, Kroustrup, J. P., Raben, Anne, Jensen, J. K. S., Meier, D. & Astrup, A., 2009, In: Obesity. 17, Suppl. 2, p. S107 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

  25. 2008
  26. Published

    Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial

    Astrup, A., Madsbad, Sten, Breum, Leif, Jensen, T. J., Kroustrup, J. P. & Larsen, T. M., 2008, In: Lancet. 372, 9653, p. 1906-1913 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Initiating or Switching to Biphasic Insulin Aspart 30/70 Therapy in Subjects with Type 2 Diabetes Mellitus. An Observational Study

    Breum, Leif, Almdal, Thomas Peter, Eiken, P., Lund, P. & Christiansen, E., 2008, In: Review of Diabetic Studies. 5, 3, p. 154-162 8 p.

    Research output: Contribution to journal › Journal article › Research

  28. 1996
  29. Published

    Aggression and personality: Association with amino acids and monoamine metabolites

    Møller, Søren, Mortensen, Erik Lykke, Breum, Leif, Alling, C., Larsen, Olav, Bøge-Rasmussen, T., Jensen, C. & Bennicke, K., Mar 1996, In: Psychological Medicine. 26, 2, p. 323-331 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. 1995
  31. Published

    Collagen metabolism in obesity: the effect of weight loss

    Rasmussen, M. H., Jensen, Lars Thorbjørn, Andersen, T., Breum, Leif & Hilsted, J., Sep 1995, In: International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. 19, 9, p. 659-63 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Long-term effects of fluoxetine on glycemic control in obese patients with non-insulin-dependent diabetes mellitus or glucose intolerance: Influence on muscle glycogen synthase and insulin receptor kinase activity

    Breum, Leif, Bjerre, U., Bak, J. F., Jacobsen, Søren & Astrup, A., 1995, In: Metabolism - Clinical and Experimental. 44, 12, p. 1570-1576 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Pharmacological and clinical studies of ephedrine and other thermogenic agonists

    Astrup, A., Breum, Leif & Toubro, S., 1995, In: Obesity Research. 3, Suppl. 4, p. 537S-540S 4 p.

    Research output: Contribution to journal › Review › Research › peer-review

  34. 1991
  35. Published

    Cardiac contractility, central haemodynamics and blood pressure regulation during semistarvation

    Stokholm, K. H., Breum, Leif & Astrup, A., 1991, In: Clinical Physiology. 11, 6, p. 513-523 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

ID: 925943