Cardiovascular Autonomic Neuropathy Is Associated With Increased Glucose Variability in People With Type 1 Diabetes
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Cardiovascular Autonomic Neuropathy Is Associated With Increased Glucose Variability in People With Type 1 Diabetes. / Naaman, Sara H.; Mizrak, Hatice I.; Lind, Nanna; Laursen, Jens C.; Kufaishi, Huda; Christensen, Marie M. B.; Ranjan, Ajenthen G.; Nørgaard, Kirsten; Hansen, Christian S.
In: Diabetes Care, Vol. 45, No. 10, 2022, p. 2461-2465.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Cardiovascular Autonomic Neuropathy Is Associated With Increased Glucose Variability in People With Type 1 Diabetes
AU - Naaman, Sara H.
AU - Mizrak, Hatice I.
AU - Lind, Nanna
AU - Laursen, Jens C.
AU - Kufaishi, Huda
AU - Christensen, Marie M. B.
AU - Ranjan, Ajenthen G.
AU - Nørgaard, Kirsten
AU - Hansen, Christian S.
N1 - © 2022 by the American Diabetes Association.
PY - 2022
Y1 - 2022
N2 - OBJECTIVE: We investigated the association between the cardiovascular autonomic neuropathy (CAN) diagnosis and glucose variability (GV) in type 1 diabetes (T1D), as autonomic dysfunction previously has been associated with increased GV.RESEARCH DESIGN AND METHODS: CAN was assessed by three recommended cardiovascular reflex tests (CARTs). Glucose metrics were obtained from 10-day blinded continuous glucose monitoring (CGM). Between-group differences in GV indices were assessed by regression analyses in 24 participants with T1D with CAN and 24 matched control subjects without CAN.RESULTS: The CAN diagnosis was associated with 4.9% (95% CI 1.0, 8.7) higher coefficient of variation (CV) (P = 0.014), 0.7 mmol/L (0.3, 1.1) higher SD (P = 0.002) of glucose, and 1.4 mmol/mol (0.0, 2.7) higher mean amplitude of glycemic excursions (P = 0.047). Lower measures of CARTs were associated with higher CV, SD, and time above range values.CONCLUSIONS: The CAN diagnosis associates with a significantly higher GV in T1D, despite a high prevalence of routine CGM use.
AB - OBJECTIVE: We investigated the association between the cardiovascular autonomic neuropathy (CAN) diagnosis and glucose variability (GV) in type 1 diabetes (T1D), as autonomic dysfunction previously has been associated with increased GV.RESEARCH DESIGN AND METHODS: CAN was assessed by three recommended cardiovascular reflex tests (CARTs). Glucose metrics were obtained from 10-day blinded continuous glucose monitoring (CGM). Between-group differences in GV indices were assessed by regression analyses in 24 participants with T1D with CAN and 24 matched control subjects without CAN.RESULTS: The CAN diagnosis was associated with 4.9% (95% CI 1.0, 8.7) higher coefficient of variation (CV) (P = 0.014), 0.7 mmol/L (0.3, 1.1) higher SD (P = 0.002) of glucose, and 1.4 mmol/mol (0.0, 2.7) higher mean amplitude of glycemic excursions (P = 0.047). Lower measures of CARTs were associated with higher CV, SD, and time above range values.CONCLUSIONS: The CAN diagnosis associates with a significantly higher GV in T1D, despite a high prevalence of routine CGM use.
KW - Autonomic Nervous System
KW - Blood Glucose
KW - Blood Glucose Self-Monitoring
KW - Cardiovascular System
KW - Diabetes Mellitus, Type 1/complications
KW - Glycated Hemoglobin A
KW - Humans
U2 - 10.2337/dc22-0117
DO - 10.2337/dc22-0117
M3 - Journal article
C2 - 35997272
VL - 45
SP - 2461
EP - 2465
JO - Diabetes Care
JF - Diabetes Care
SN - 0149-5992
IS - 10
ER -
ID: 325890052