Cardiovascular Autonomic Neuropathy Is Associated With Increased Glucose Variability in People With Type 1 Diabetes
Research output: Contribution to journal › Journal article › Research › peer-review
OBJECTIVE: We investigated the association between the cardiovascular autonomic neuropathy (CAN) diagnosis and glucose variability (GV) in type 1 diabetes (T1D), as autonomic dysfunction previously has been associated with increased GV.
RESEARCH DESIGN AND METHODS: CAN was assessed by three recommended cardiovascular reflex tests (CARTs). Glucose metrics were obtained from 10-day blinded continuous glucose monitoring (CGM). Between-group differences in GV indices were assessed by regression analyses in 24 participants with T1D with CAN and 24 matched control subjects without CAN.
RESULTS: The CAN diagnosis was associated with 4.9% (95% CI 1.0, 8.7) higher coefficient of variation (CV) (P = 0.014), 0.7 mmol/L (0.3, 1.1) higher SD (P = 0.002) of glucose, and 1.4 mmol/mol (0.0, 2.7) higher mean amplitude of glycemic excursions (P = 0.047). Lower measures of CARTs were associated with higher CV, SD, and time above range values.
CONCLUSIONS: The CAN diagnosis associates with a significantly higher GV in T1D, despite a high prevalence of routine CGM use.
Original language | English |
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Journal | Diabetes Care |
Volume | 45 |
Issue number | 10 |
Pages (from-to) | 2461-2465 |
Number of pages | 5 |
ISSN | 0149-5992 |
DOIs | |
Publication status | Published - 2022 |
Bibliographical note
© 2022 by the American Diabetes Association.
- Autonomic Nervous System, Blood Glucose, Blood Glucose Self-Monitoring, Cardiovascular System, Diabetes Mellitus, Type 1/complications, Glycated Hemoglobin A, Humans
Research areas
ID: 325890052