Defective amplification of the late phase insulin response to glucose by GIP in obese Type II diabetic patients

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Glucagon-like-peptide-1 (GLP-1) is strongly insulinotropic in patients with Type II (non-insulin-dependent) diabetes mellitus, whereas glucose-dependent insulinotropic polypeptide (GIP) is less effective. Our investigation evaluated "early" (protocol 1) - and "late phase" (protocol 2) insulin and C-peptide responses to GLP-1 and GIP stimulation in patients with Type II diabetes.
Original languageEnglish
JournalDiabetologia
Volume45
Issue number8
Pages (from-to)1111-9
Number of pages9
ISSN0012-186X
DOIs
Publication statusPublished - 1 Aug 2002

ID: 34069971