Pleiotropic effects of GIP on islet function involve osteopontin
Research output: Contribution to journal › Journal article › Research › peer-review
The incretin hormone GIP (glucose-dependent insulinotropic polypeptide) promotes pancreatic β-cell function by potentiating insulin secretion and β-cell proliferation. Recently, a combined analysis of several genome-wide association studies (Meta-analysis of Glucose and Insulin-Related Traits Consortium [MAGIC]) showed association to postprandial insulin at the GIP receptor (GIPR) locus. Here we explored mechanisms that could explain the protective effects of GIP on islet function.
| Original language | English |
|---|---|
| Journal | Diabetes |
| Volume | 60 |
| Issue number | 9 |
| Pages (from-to) | 2424-33 |
| Number of pages | 10 |
| ISSN | 0012-1797 |
| DOIs | |
| Publication status | Published - Sep 2011 |
- Alleles, Diabetes Mellitus, Type 2, Gastric Inhibitory Polypeptide, Genome-Wide Association Study, Glucagon-Like Peptide 1, Humans, Insulin, Insulin-Secreting Cells, Islets of Langerhans, Male, Osteopontin
Research areas
ID: 40176782