Kinetic analysis of the human blood-brain barrier transport of lactate and its influence by hypercapnia

Research output: Contribution to journal › Journal article › Research › peer-review

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Kinetic analysis of the human blood-brain barrier transport of lactate and its influence by hypercapnia. / Knudsen, G M; Paulson, O B; Hertz, M M.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 11, No. 4, 07.1991, p. 581-6.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Knudsen, GM, Paulson, OB & Hertz, MM 1991, 'Kinetic analysis of the human blood-brain barrier transport of lactate and its influence by hypercapnia', Journal of Cerebral Blood Flow and Metabolism, vol. 11, no. 4, pp. 581-6. https://doi.org/10.1038/jcbfm.1991.107

APA

Knudsen, G. M., Paulson, O. B., & Hertz, M. M. (1991). Kinetic analysis of the human blood-brain barrier transport of lactate and its influence by hypercapnia. Journal of Cerebral Blood Flow and Metabolism, 11(4), 581-6. https://doi.org/10.1038/jcbfm.1991.107

Vancouver

Knudsen GM, Paulson OB, Hertz MM. Kinetic analysis of the human blood-brain barrier transport of lactate and its influence by hypercapnia. Journal of Cerebral Blood Flow and Metabolism. 1991 Jul;11(4):581-6. https://doi.org/10.1038/jcbfm.1991.107

Author

Knudsen, G M ; Paulson, O B ; Hertz, M M. / Kinetic analysis of the human blood-brain barrier transport of lactate and its influence by hypercapnia. In: Journal of Cerebral Blood Flow and Metabolism. 1991 ; Vol. 11, No. 4. pp. 581-6.

Bibtex

@article{7e470bda8d534ec7bf193221e580af76,
title = "Kinetic analysis of the human blood-brain barrier transport of lactate and its influence by hypercapnia",
abstract = "Blood-brain barrier permeability to L-lactate was studied in 18 patients with the double indicator technique. Venous outflow curves were obtained during normo- and hypercapnia and were analyzed by means of a model that takes tracer backflux and capillary heterogeneity of transit times into account. The average unidirectional extraction of L-lactate was 15%; the transport from the blood to the brain (PS1) was 0.081 ml g-1 min-1 and the transport from the brain to the blood (PS2) was on the same order of magnitude. In hypercapnia, arterial pH decreased from 7.39 to 7.26 and PS1 to L-lactate increased significantly by 110%. PS2 also increased although a statistically significant difference compared to the resting state was not reached. It is concluded that L-lactate is easily taken up by the human brain, and that the mechanism by which it crosses the blood-brain barrier is equilibrative. Furthermore, the brain permeability to lactate is enhanced by hypercapnia and the mechanism is believed to act through the decrease in pH.",
keywords = "Adult, Aged, Blood-Brain Barrier, Brain/metabolism, Cell Membrane Permeability, Humans, Hypercapnia/metabolism, Kinetics, Lactates/blood, Lactic Acid, Middle Aged, Surface Properties",
author = "Knudsen, {G M} and Paulson, {O B} and Hertz, {M M}",
year = "1991",
month = jul,
doi = "10.1038/jcbfm.1991.107",
language = "English",
volume = "11",
pages = "581--6",
journal = "Journal of Cerebral Blood Flow and Metabolism",
issn = "0271-678X",
publisher = "SAGE Publications",
number = "4",

}

RIS

TY - JOUR

T1 - Kinetic analysis of the human blood-brain barrier transport of lactate and its influence by hypercapnia

AU - Knudsen, G M

AU - Paulson, O B

AU - Hertz, M M

PY - 1991/7

Y1 - 1991/7

N2 - Blood-brain barrier permeability to L-lactate was studied in 18 patients with the double indicator technique. Venous outflow curves were obtained during normo- and hypercapnia and were analyzed by means of a model that takes tracer backflux and capillary heterogeneity of transit times into account. The average unidirectional extraction of L-lactate was 15%; the transport from the blood to the brain (PS1) was 0.081 ml g-1 min-1 and the transport from the brain to the blood (PS2) was on the same order of magnitude. In hypercapnia, arterial pH decreased from 7.39 to 7.26 and PS1 to L-lactate increased significantly by 110%. PS2 also increased although a statistically significant difference compared to the resting state was not reached. It is concluded that L-lactate is easily taken up by the human brain, and that the mechanism by which it crosses the blood-brain barrier is equilibrative. Furthermore, the brain permeability to lactate is enhanced by hypercapnia and the mechanism is believed to act through the decrease in pH.

AB - Blood-brain barrier permeability to L-lactate was studied in 18 patients with the double indicator technique. Venous outflow curves were obtained during normo- and hypercapnia and were analyzed by means of a model that takes tracer backflux and capillary heterogeneity of transit times into account. The average unidirectional extraction of L-lactate was 15%; the transport from the blood to the brain (PS1) was 0.081 ml g-1 min-1 and the transport from the brain to the blood (PS2) was on the same order of magnitude. In hypercapnia, arterial pH decreased from 7.39 to 7.26 and PS1 to L-lactate increased significantly by 110%. PS2 also increased although a statistically significant difference compared to the resting state was not reached. It is concluded that L-lactate is easily taken up by the human brain, and that the mechanism by which it crosses the blood-brain barrier is equilibrative. Furthermore, the brain permeability to lactate is enhanced by hypercapnia and the mechanism is believed to act through the decrease in pH.

KW - Adult

KW - Aged

KW - Blood-Brain Barrier

KW - Brain/metabolism

KW - Cell Membrane Permeability

KW - Humans

KW - Hypercapnia/metabolism

KW - Kinetics

KW - Lactates/blood

KW - Lactic Acid

KW - Middle Aged

KW - Surface Properties

U2 - 10.1038/jcbfm.1991.107

DO - 10.1038/jcbfm.1991.107

M3 - Journal article

C2 - 2050746

VL - 11

SP - 581

EP - 586

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

SN - 0271-678X

IS - 4

ER -

ID: 275031525