Kinetic analysis of the human blood-brain barrier transport of lactate and its influence by hypercapnia
Research output: Contribution to journal › Journal article › Research › peer-review
Blood-brain barrier permeability to L-lactate was studied in 18 patients with the double indicator technique. Venous outflow curves were obtained during normo- and hypercapnia and were analyzed by means of a model that takes tracer backflux and capillary heterogeneity of transit times into account. The average unidirectional extraction of L-lactate was 15%; the transport from the blood to the brain (PS1) was 0.081 ml g-1 min-1 and the transport from the brain to the blood (PS2) was on the same order of magnitude. In hypercapnia, arterial pH decreased from 7.39 to 7.26 and PS1 to L-lactate increased significantly by 110%. PS2 also increased although a statistically significant difference compared to the resting state was not reached. It is concluded that L-lactate is easily taken up by the human brain, and that the mechanism by which it crosses the blood-brain barrier is equilibrative. Furthermore, the brain permeability to lactate is enhanced by hypercapnia and the mechanism is believed to act through the decrease in pH.
Original language | English |
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Journal | Journal of Cerebral Blood Flow and Metabolism |
Volume | 11 |
Issue number | 4 |
Pages (from-to) | 581-6 |
Number of pages | 6 |
ISSN | 0271-678X |
DOIs | |
Publication status | Published - Jul 1991 |
- Adult, Aged, Blood-Brain Barrier, Brain/metabolism, Cell Membrane Permeability, Humans, Hypercapnia/metabolism, Kinetics, Lactates/blood, Lactic Acid, Middle Aged, Surface Properties
Research areas
ID: 275031525