Niels Erik Skakkebæk

Niels Erik Skakkebæk

Affiliate Professor

Member of:

  • Paediatrics


  1. 2011
  2. Published

    Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat

    Kristensen, D. M., Hass, U., Lesné, L., Lottrup, G., Jacobsen, P. R., Desdoits-Lethimonier, C., Boberg, J., Petersen, Jørgen Holm, Toppari, J., Jensen, T. K., Brunak, Søren, Skakkebæk, Niels Erik, Nellemann, C., Main, Katharina Maria, Jégou, B. & Leffers, H., 2011, In: Human Reproduction. 26, 1, p. 235-44 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Serum concentrations of Anti-Müllerian Hormone (AMH) in 95 patients with Klinefelter syndrome with or without cryptorchidism

    Aksglaede, L., Christiansen, P., Sørensen, K., Boas, M., Linneberg, Allan René, Main, Katharina Maria, Andersson, A., Skakkebæk, Niels Erik & Juul, Anders, 2011, In: Acta Paediatrica. 100, 6, p. 839-845 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Sex chromosome aneuploidy and anthropometry

    Aksglæde, L., Skakkebæk, Niels Erik & Juul, Anders, 2011, Handbook of Anthropometry: Physical measures of human form in health and disease. Springer

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  5. 2010
  6. Published

    OCT4 and downstream factors are expressed in human somatic urogenital epithelia and in culture of epididymal spheres

    Kristensen, D. M., Nielsen, J. E., Kalisz, M., Dalgaard, M. D., Audouze, K., Larsen, M. E., Jacobsen, G. K., Horn, T., Brunak, S., Skakkebaek, N. E., Leffers, H., Kristensen, D. M., Nielsen, J. E., Kalisz, M., Dalgaard, M. D., Audouze, K. M. L., Larsen, M. E., Jacobsen, G. K., Horn, T., Brunak, S. & 2 others, Skakkebæk, Niels Erik & Leffers, H., 1 Nov 2010, In: Molecular Human Reproduction. 16, 11, p. 835-45 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Serum inhibin-b in fertile men is strongly correlated with low but not high sperm counts: a coordinated study of 1,797 European and US men

    Jørgensen, N., Liu, F., Andersson, A., Vierula, M., Irvine, D. S., Auger, J., Brazil, C. K., Drobnis, E. Z., Jensen, T. K., Jouannet, P., Overstreet, J. W., Redmon, J. B., Sparks, A., Toppari, J., Wang, C., Skakkebæk, Niels Erik & Swan, S. H., 1 Nov 2010, In: Fertility and Sterility. 94, 6, p. 2128-34 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Carcinoma in situ testis displays permissive chromatin modifications similar to immature foetal germ cells

    Almstrup, Kristian, Nielsen, J. E., Mlynarska, O., Jansen, M. T., Jørgensen, A., Skakkebæk, Niels Erik & Rajpert-De Meyts, E., 12 Oct 2010, In: British Journal of Cancer. 103, 8, p. 1269-76 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Childhood exposure to phthalates: associations with thyroid function, insulin-like growth factor I, and growth

    Boas, M., Frederiksen, H., Feldt-Rasmussen, Ulla, Skakkebæk, Niels Erik, Hegedüs, L., Hilsted, L. M., Juul, Anders & Main, Katharina Maria, 1 Oct 2010, In: Environmental Health Perspectives. 118, 10, p. 1458-64 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Cryptorchidism and hypospadias as a sign of testicular dysgenesis syndrome (TDS): environmental connection

    Toppari, J., Virtanen, H. E., Main, Katharina Maria & Skakkebæk, Niels Erik, 1 Oct 2010, In: Birth Defects Research. Part A: Clinical and Molecular Teratology. 88, 10, p. 910-9 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Testicular non-seminoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

    Schmoll, H., Jordan, K., Huddart, R., Pes, M. P. L., Horwich, A., Fizazi, K., Kataja, V., Rajpert-De Meyts, E., Skakkebæk, Niels Erik, ESMO Guidelines Working Group, E. G. W. G. & von der Maase, H. R. R., 1 May 2010, In: Annals of Oncology. 21 Suppl 5, p. v147-54

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Testicular seminoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

    Schmoll, H., Jordan, K., Huddart, R., Pes, M. P. L., Horwich, A., Fizazi, K., Kataja, V., Rajpert-De Meyts, E., Skakkebæk, Niels Erik, ESMO Guidelines Working Group, E. G. W. G. & von der Maase, H. R. R., 1 May 2010, In: Annals of Oncology. 21 Suppl 5, p. v140-6

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract

    Jensen, Martin Blomberg, Nielsen, J. E., Jørgensen, A., Rajpert-De Meyts, E., Kristensen, D. M., Jørgensen, N., Skakkebæk, Niels Erik, Juul, Anders & Leffers, H., 1 May 2010, In: Human Reproduction. 25, 5, p. 1303-11 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Caffeine intake and semen quality in a population of 2,554 young Danish men

    Jensen, T. K., Swan, S. H., Skakkebæk, Niels Erik, Rasmussen, S. & Jørgensen, N., 15 Apr 2010, In: American Journal of Epidemiology. 171, 8, p. 883-91 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Country-specific chemical signatures of persistent environmental compounds in breast milk

    Krysiak-Baltyn, K., Toppari, J., Skakkebaek, N. E., Jensen, T. S., Virtanen, H. E., Schramm, K-W., Shen, H., Vartiainen, T., Kiviranta, H., Taboureau, O., Brunak, S., Main, K. M., Krysiak-Baltyn, K., Toppari, J., Skakkebaek, N. E., Jensen, T. S., Virtanen, H. E., Schramm, K-W., Shen, H., Vartiainen, T. & 4 others, Kiviranta, H., Taboureau, O., Brunak, S. & Main, Katharina Maria, 1 Apr 2010, In: International Journal of Andrology. 33, 2, p. 270-8 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Genital anomalies in boys and the environment

    Main, Katharina Maria, Skakkebæk, Niels Erik, Virtanen, H. E. & Toppari, J., 1 Apr 2010, In: Best Practice & Research: Clinical Endocrinology & Metabolism. 24, 2, p. 279-89 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Hypothesis: exposure to endocrine-disrupting chemicals may interfere with timing of puberty

    Mouritsen, Annette Korsholm, Aksglaede, L., Sørensen, K., Mogensen, S. S., Leffers, H., Main, Katharina Maria, Frederiksen, H., Andersson, A., Skakkebæk, Niels Erik & Juul, Anders, 1 Apr 2010, In: International Journal of Andrology. 33, 2, p. 346-59 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Proceedings of the 5th Copenhagen Workshop on endocrine disrupters: ubiquitous endocrine disrupters and possible human health effects. Preface

    Andersson, A., Bay, K., Grigor, K. M., Toppari, J. & Skakkebæk, Niels Erik, 1 Apr 2010, In: International Journal of Andrology. 33, 2, p. 251 1 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Testicular dysgenesis syndrome comprises some but not all cases of hypospadias and impaired spermatogenesis

    Jørgensen, N., Rajpert-De Meyts, E., Main, Katharina Maria & Skakkebæk, Niels Erik, 1 Apr 2010, In: International Journal of Andrology. 33, 2, p. 298-303 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Testicular germ cell cancer incidence in an immigration perspective, Denmark, 1978 to 2003

    Schmiedel, S., Schüz, J., Skakkebæk, Niels Erik & Johansen, C., 1 Apr 2010, In: Journal of Urology. 183, 4, p. 1378-82 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Semen quality, reproductive hormones and fertility of men operated for hypospadias

    Asklund, C., Jensen, T. K., Main, Katharina Maria, Sobotka, T., Skakkebæk, Niels Erik & Jørgensen, N., 1 Feb 2010, In: International Journal of Andrology. 33, 1, p. 80-7 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Assessment of circulating sex steroid levels in prepubertal and pubertal boys and girls by a novel ultrasensitive gas chromatography-tandem mass spectrometry method

    Courant, F., Aksglæde, L., Antignac, J., Monteau, F., Sørensen, K., Andersson, A., Skakkebæk, Niels Erik, Juul, Anders & Bizec, B. L., 1 Jan 2010, In: Journal of Clinical Endocrinology and Metabolism. 95, 1, p. 82-92 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Normal reference ranges for semen quality and their relations to fecundity

    Skakkebæk, Niels Erik, 1 Jan 2010, In: Asian Journal of Andrology. 12, 1, p. 95-8 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Changes in Anti-Mullerian Hormone (AMH) throughout the Life Span: A Population-Based Study of 1027 Healthy Males from Birth (Cord Blood) to the Age of 69 Years

    Aksglæde, L., Sørensen, K., Boas, M., Mouritsen, Annette Korsholm, Hagen, C. P., Jensen, R. B., Petersen, J. H., Linneberg, Allan René, Andersson, A. M., Main, Katharina Maria, Skakkebæk, Niels Erik & Juul, Anders, 2010, In: Journal of Clinical Endocrinology and Metabolism. 95, 12, p. 5357-5364 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Changes in Anti-Müllerian Hormone (AMH) throughout the Life Span: A Population-Based Study of 1027 Healthy Males from Birth (Cord Blood) to the Age of 69 Years

    Aksglæde, L., Sørensen, K., Boas, M., Mouritsen, A. K. M., Hagen, C., Jensen, R., Petersen, Jørgen Holm, Linneberg, Allan René, Andersson, A., Main, Katharina Maria, Skakkebæk, Niels Erik & Juul, Anders, 2010, In: Journal of Clinical Endocrinology and Metabolism. 95, 12, p. 5357-5364 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Changes in anti-Müllerian hormone (AMH) throughout the life span: a population-based study of 1027 healthy males from birth (cord blood) to the age of 69 years

    Aksglaede, L., Sørensen, K., Boas, M., Mouritsen, A., Hagen, C. P., Jensen, R. B., Petersen, J. H., Linneberg, Allan René, Andersson, A., Main, Katharina Maria, Skakkebæk, Niels Erik & Juul, Anders, 2010, In: Journal of Clinical Endocrinology and Metabolism. 95, 12, p. 5357-64 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Cryptorchidism, hypospadias, testicular tumours and testicular dysgenesis syndrome

    Rajpert-De Meyts, E., Main, Katharina Maria, Toppari, J. & Skakkebæk, Niels Erik, 2010, Endocrinology.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  28. 2009
  29. Published

    Analysis of gene expression profiles of microdissected cell populations indicates that testicular carcinoma in situ is an arrested gonocyte

    Sonne, Si Brask, Almstrup, Kristian, Dalgaard, M., Juncker, A. S., Edsgard, D., Ruban, L., Harrison, N. J., Schwager, C., Abdollahi, A., Huber, P. E., Brunak, Søren, Gjerdrum, L. M., Moore, H. D., Andrews, P. W., Skakkebæk, Niels Erik, Rajpert-De Meyts, E. & Leffers, H., 15 Jun 2009, In: Current Cancer Research. 69, 12, p. 5241-50 10 p.

    Research output: Contribution to journalJournal articleResearch

  30. Published
  31. Published

    Re: The true incidence of cryptorchidism in Denmark: D. Cortes, E. M. Kjellberg, M. Breddam and J. Thorup, J Urol 2008; 179: 314-318

    Thorup, Jørgen Mogens, Cortes, Dina, Main, Katharina Maria, Skakkebæk, Niels Erik & Toppari, J., Feb 2009, In: The Journal of Urology. 181, 2, p. 922-4 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Early puberty in internationally adopted girls: hormonal and clinical markers of puberty in 276 girls examined biannually over two years

    Teilmann, Grete Katrine, Petersen, Jørgen Holm, Gormsen, M., Damgaard, K., Skakkebæk, Niels Erik, Jensen, T. K., Teilmann, Grete Katrine, Petersen, J. H., Gormsen, M., Damgaard, K., Skakkebæk, Niels Erik & Jensen, T. K., 1 Jan 2009, In: Hormone Research. 72, 4, p. 236-46 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Gene expression profiles of mouse spermatogenesis during recovery from irradiation

    Shah, F. J., Tanaka, M., Nielsen, J. E., Iwamoto, T., Kobayashi, S., Skakkebæk, Niels Erik, Leffers, H., Almstrup, K., Shah, F. J., Tanaka, M., Nielsen, J. E., Iwamoto, T., Kobayashi, S., Skakkebæk, Niels Erik, Leffers, H. & Almstrup, Kristian, 1 Jan 2009, In: Reproductive Biology and Endocrinology. 7, p. 130

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Acquired cryptorchidism is frequent in infancy and childhood

    Wohlfahrt-Veje, C., Boisen, K. A., Boas, M., Damgaard, I. N., Kai, C. M., Schmidt, I. M., Chellakooty, M., Suomi, A., Toppari, J., Skakkebæk, Niels Erik & Main, Katharina Maria, 2009, In: International Journal of Andrology. 32, 4, p. 423-8 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Cryptorchidism as part of the testicular dysgenesis syndrome: the environmental connection

    Main, Katharina Maria, Skakkebæk, Niels Erik & Toppari, J., 2009, In: Endocrine Development. 14, p. 167-73 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Do perfluoroalkyl compounds impair human semen quality?

    Joensen, Ulla Nordström, Bossi, R., Leffers, H., Jensen, A. A., Skakkebæk, Niels Erik & Jørgensen, N., 2009, In: Environmental Health Perspectives. 117, 6, p. 923-7 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Is there a problem with male reproduction?

    Joensen, Ulla Nordström, Skakkebæk, Niels Erik & Jørgensen, N., 2009, In: Nature Clinical Practice Endocrinology & Metabolism. 5, 3, p. 144-5 1 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Recent decline in age at breast development: the Copenhagen Puberty Study

    Aksglaede, L., Sørensen, K., Petersen, J. H., Skakkebæk, Niels Erik & Juul, Anders, 2009, In: Pediatrics. 123, 5, p. e932-9

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Recent decline in age at breast development: the Copenhagen Puberty Study

    Aksglaede, L., Sørensen, K., Petersen, Jørgen Holm, Skakkebæk, Niels Erik & Juul, Anders, 2009, In: Pediatrics Electronic Pages. 123, 5, p. e932-9

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Testicular dysgenesis syndrome: foetal origin of adult reproductive problems

    Wohlfahrt-Veje, C., Main, Katharina Maria & Skakkebæk, Niels Erik, 2009, In: Clinical Endocrinology. 71, 4, p. 459-65 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. 2008
  42. Published

    Insulin-like factor 3 levels in second-trimester amniotic fluid

    Bay, K., Cohen, A. S., Jørgensen, Finn Stener, Jørgensen, C., Lind, A. M., Skakkebæk, Niels Erik & Andersson, A., 1 Oct 2008, In: Journal of Clinical Endocrinology and Metabolism. 93, 10, p. 4048-51 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Urinary excretion of phthalates and paraben after repeated whole-body topical application in humans

    Janjua, N. R., Frederiksen, H., Skakkebæk, Niels Erik, Wulf, H. C. & Andersson, A., 1 Apr 2008, In: International Journal of Andrology. 31, 2, p. 118-30 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published
  45. Published

    Adverse trends in male reproductive health: we may have reached a crucial 'tipping point'

    Andersson, A., Jørgensen, N., Main, Katharina Maria, Toppari, J., Rajpert-De Meyts, E., Leffers, H., Juul, Anders, Jensen, T. K. & Skakkebæk, Niels Erik, 2008, In: International Journal of Andrology. 31, 2, p. 74-80 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Association of the polymorphism of the CAG repeat in the mitochondrial DNA polymerase gamma gene (POLG) with testicular germ-cell cancer

    Jensen, Martin Blomberg, Leffers, H., Petersen, Jørgen Holm, Daugaard, G., Skakkebæk, Niels Erik & Rajpert-De Meyts, E., 2008, In: Annals of Oncology. 19, 11, p. 1910-4 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Concentrations of persistent organochlorine compounds in human milk and placenta are higher in Denmark than in Finland

    Shen, H., Main, K. M., Andersson, A. M., Damgaard, I. N., Virtanen, H. E., Toppari, J., Schramm, K. W. & Skakkebæk, Niels Erik, 2008, In: Human Reproduction. 23, 1, p. 201-210 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Environmental factors and puberty timing: expert panel research needs

    Louis, G. M. B., Jr, L. E. G., Marcus, M., Ojeda, S. R., Pescovitz, O. H., Witchel, S. F., Sippell, W., Abbott, D. H., Soto, A., Tyl, R. W., Bourguignon, J. P., Swan, S. H., Golub, M. S., Wabitsch, M., Toppari, J., Euling, S. Y. & Skakkebæk, Niels Erik, 2008, In: Pediatrics. 121 Suppl 3, p. S192-S207

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing

    Crain, D. A., Janssen, S. J., Edwards, T. M., Heindel, J., Ho, S., Hunt, P., Iguchi, T., Juul, Anders, McLachlan, J. A., Schwartz, J., Skakkebæk, Niels Erik, Soto, A. M., Swan, S., Walker, C., Woodruff, T. K., Woodruff, T. J., Giudice, L. C. & Guillette, L. J., 2008, In: Fertility and Sterility. 90, 4, p. 911-40 30 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Low semen volume in 47 adolescents and adults with 47,XXY Klinefelter or 46,XX male syndrome

    Aksglaede, L., Jørgensen, N., Skakkebæk, Niels Erik & Juul, Anders, 2008, In: International Journal of Andrology. 32, 4, p. 376-84 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Mere Testikelkræft og dårlig sædkvalitet

    Skakkebæk, Niels Erik, 2008, In: Tidsskrift for Den norske lægeforening. 128, p. 554-554

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Origin of pluripotent germ cell tumours: the role of microenvironment during embryonic development

    Kristensen, D. M., Sonne, Si Brask, Ottesen, A. M., Perrett, R. M., Nielsen, J. E., Almstrup, Kristian, Skakkebæk, Niels Erik, Leffers, H. & Meyts, E. R., 2008, In: Molecular and Cellular Endocrinology. 288, 1-2, p. 111-8 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Role of environmental factors in the timing of puberty

    Euling, S. Y., Selevan, S. G., Pescovitz, O. H. & Skakkebæk, Niels Erik, 2008, In: Pediatrics. 121 Suppl 3, p. S167-S171

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Semen quality in sub-fertile range for a significant proportion of young men from the general German population: a co-ordinated, controlled study of 791 men from Hamburg and Leipzig

    Paasch, U., Salzbrunn, A., Glander, H. J., Plambeck, K., Salzbrunn, H., Grunewald, S., Stucke, J., Vierula, M., Jorgensen, N. & Skakkebæk, Niels Erik, 2008, In: International Journal of Andrology. 31, 2, p. 93-102 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Sons conceived by assisted reproduction techniques inherit deletions in the azoospermia factor (AZF) region of the Y chromosome and the DAZ gene copy number

    Mau Kai, C., Juul, Anders, McElreavey, K., Ottesen, A. M., Garn, I. D., Main, Katharina Maria, Loft, A., Jørgensen, N., Skakkebæk, Niels Erik, Andersen, A. N. & Rajpert-De Meyts, E., 2008, In: Human Reproduction. 23, 7, p. 1669-1678 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Testicular dysgenesis syndrome and the origin of carcinoma in situ testis

    Sonne, Si Brask, Kristensen, D. M., Novotny, G. W., Olesen, I. A., Nielsen, J. E., Skakkebæk, Niels Erik, Rajpert-De Meyts, E. & Leffers, H., 2008, In: International Journal of Andrology. 31, 2, p. 275-87 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects

    Sharpe, R. M. & Skakkebæk, Niels Erik, 2008, In: Fertility and Sterility. 89, 2 Suppl, p. e33-e38

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    The faroes statement: human health effects of developmental exposure to chemicals in our environment

    Grandjean, P., Bellinger, D., Bergman, A., Cordier, S., vey-Smith, G., Eskenazi, B., Gee, D., Gray, K., Hanson, M., den, H. P. V., Heindel, J. J., Heinzow, B., Hertz-Picciotto, I., Hu, H., Huang, T. T., Jensen, T. K., Landrigan, P. J., McMillen, I. C., Murata, K., Ritz, B. & 4 others, Schoeters, G., Skerfving, S., Weihe, P. & Skakkebæk, Niels Erik, 2008, In: Basic & Clinical Pharmacology & Toxicology. 102, 2, p. 73-75 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. 2007
  60. Published

    Age at voice break in Danish boys: effects of pre-pubertal body mass index and secular trend

    Juul, Anders, Magnusdottir, S., Scheike, T., Prytz, S. & Skakkebæk, Niels Erik, 1 Dec 2007, In: International Journal of Andrology. 30, 6, p. 537-42 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. Published

    Secular decline in male testosterone and sex hormone binding globulin serum levels in Danish population surveys

    Andersson, A., Jensen, T. K., Juul, Anders, Petersen, Jørgen Holm, Jørgensen, T. & Skakkebæk, Niels Erik, 1 Dec 2007, In: Journal of Clinical Endocrinology and Metabolism. 92, 12, p. 4696-705 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. Published

    Self-rated health and semen quality among 3,457 young Danish men

    Jensen, T. K., Jørgensen, N., Asklund, C., Carlsen, E., Kristensen, T. S., Holm, M., Skakkebæk, Niels Erik & Jensen, T. K., 1 Nov 2007, In: Fertility and Sterility. 88, 5, p. 1366-73 8 p.

    Research output: Contribution to journalJournal articleResearch

  63. Published

    Insulin-like factor 3 levels in cord blood and serum from children: effects of age, postnatal hypothalamic-pituitary-gonadal axis activation, and cryptorchidism

    Bay, K., Virtanen, H. E., Hartung, S., Ivell, R., Main, Katharina Maria, Skakkebæk, Niels Erik, Andersson, A., Toppari, J. & Nordic Cryptorchidism Study Group, N. C. S. G., 1 Oct 2007, In: Journal of Clinical Endocrinology and Metabolism. 92, 10, p. 4020-7 8 p.

    Research output: Contribution to journalJournal articleResearch

  64. Published

    Testicular dysgenesis syndrome and carcinoma in situ of the testes

    Joensen, Ulla Nordström, Jorgensen, N. & Skakkebæk, Niels Erik, Aug 2007, In: Nature Clinical Practice Urology. 4, 8, p. 402-403 2 p.

    Research output: Contribution to journalReviewResearchpeer-review

  65. Published

    Metabolism of phthalates in humans

    Frederiksen, H., Skakkebæk, Niels Erik & Andersson, A., 1 Jul 2007, In: Molecular Nutrition & Food Research. 51, 7, p. 899-911 13 p.

    Research output: Contribution to journalJournal articleResearch

  66. Published

    Development and descent of the testis in relation to cryptorchidism

    Virtanen, H. E., Cortes, Dina, Rajpert-De Meyts, E., Ritzén, E. M., Nordenskjöld, A., Skakkebæk, Niels Erik & Toppari, J., 1 May 2007, In: Acta Paediatrica. 96, 5, p. 622-7 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  67. Published

    Fertility treatment and reproductive health of male offspring: a study of 1,925 young men from the general population

    Jensen, T. K., Jørgensen, N., Asklund, C., Carlsen, E., Holm, M., Skakkebæk, Niels Erik & Jensen, T. K., 1 Mar 2007, In: American Journal of Epidemiology. 165, 5, p. 583-90 8 p.

    Research output: Contribution to journalJournal articleResearch

  68. Published

    Primary testicular failure in Klinefelter's syndrome: the use of bivariate luteinizing hormone-testosterone reference charts

    Aksglaede, L., Andersson, A., Jørgensen, N., Jensen, T. K., Carlsen, E., McLachlan, R. I., Skakkebæk, Niels Erik, Petersen, Jørgen Holm & Juul, Anders, 1 Feb 2007, In: Clinical Endocrinology. 66, 2, p. 276-81 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  69. Published

    Origin of testicular germ cell neoplasia: The role of sex chromosomes

    Rajpert-De Meyts, E., Ottesen, A. M., Høi-Hansen, Christina Engel, Sonne, Si Brask, Leffers, H. & Skakkebæk, Niels Erik, 1 Jan 2007, The Y Chromosome and Male Germ Cell Biology in Health and Diseases. World Scientific Publishing Co., p. 289-308 20 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  70. Published

    Analysis of gene expression in normal and neoplastic human testis: new roles of RNA

    Novotny, G. W., Nielsen, J. E., Sonne, Si Brask, Skakkebæk, Niels Erik, Rajpert-De Meyts, E., Leffers, H. & Sonne, Si Brask, 2007, In: International Journal of Andrology. 30, 4, p. 316-327

    Research output: Contribution to journalJournal articleResearchpeer-review

  71. Published

    Changes in the profile of simple mucin-type O-glycans and polypeptide GalNAc-transferases in human testis and testicular neoplasms are associated with germ cell maturation and tumour differentiation

    Rajpert-De Meyts, E., Poll, S. N., Goukasian, I., Jeanneau, C., Herlihy, A. S., Bennett, Eric Paul, Skakkebæk, Niels Erik, Clausen, Henrik, Giwercman, A. & Mandel, Ulla, 2007, In: Virchows Archiv. 451, 4, p. 805-14 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  72. Published

    Environment, testicular dysgenesis and carcinoma in situ testis

    Olesen, I. A., Sonne, Si Brask, Hoei-Hansen, C. E., Rajpert-DeMeyts, E. & Skakkebæk, Niels Erik, 2007, In: Best Practice & Research: Clinical Endocrinology & Metabolism. 21, 3, p. 462-78 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  73. Published

    European consensus conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus Group (EGCCCG): part II

    Krege, S., Beyer, J., Souchon, R., Albers, P., Albrecht, W., Algaba, F., Bamberg, M., Bodrogi, I., Bokemeyer, C., Cavallin-Ståhl, E., Classen, J., Clemm, C., Cohn-Cedermark, G., Culine, S., Daugaard, G., De Mulder, P. H. M., De Santis, M., de Wit, M., de Wit, R., Derigs, H. G. & 63 others, Dieckmann, K., Dieing, A., Droz, J., Fenner, M., Fizazi, K., Flechon, A., Fosså, S. D., del Muro, X. G., Gauler, T., Geczi, L., Gerl, A., Germa-Lluch, J. R., Gillessen, S., Hartmann, J. T., Hartmann, M., Heidenreich, A., Hoeltl, W., Horwich, A., Huddart, R., Jewett, M., Joffe, J., Jones, W. G., Kisbenedek, L., Klepp, O., Kliesch, S., Koehrmann, K. U., Kollmannsberger, C., Kuczyk, M., Laguna, P., Galvis, O. L., Loy, V., Mason, M. D., Mead, G. M., Mueller, R., Nichols, C., Nicolai, N., Oliver, T., Ondrus, D., Oosterhof, G. O. N., Paz-Ares, L., Pizzocaro, G., Pont, J., Pottek, T., Powles, T., Rick, O., Rosti, G., Salvioni, R., Scheiderbauer, J., Schmelz, H., Schmidberger, H., Schmoll, H., Schrader, M., Sedlmayer, F., Skakkebæk, Niels Erik, Sohaib, A., Tjulandin, S., Warde, P., Weinknecht, S., Weissbach, L., Wittekind, C., Winter, E., Wood, L. & von der Maase, H., 2007, In: European Urology. 53, 3, p. 497-513 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  74. Published

    European consensus conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus group (EGCCCG): part I

    Krege, S., Beyer, J., Souchon, R., Albers, P., Albrecht, W., Algaba, F., Bamberg, M., Bodrogi, I., Bokemeyer, C., Cavallin-Ståhl, E., Classen, J., Clemm, C., Cohn-Cedermark, G., Culine, S., Daugaard, G., De Mulder, P. H. M., De Santis, M., de Wit, M., de Wit, R., Derigs, H. G. & 63 others, Dieckmann, K., Dieing, A., Droz, J., Fenner, M., Fizazi, K., Flechon, A., Fosså, S. D., del Muro, X. G., Gauler, T., Geczi, L., Gerl, A., Germa-Lluch, J. R., Gillessen, S., Hartmann, J. T., Hartmann, M., Heidenreich, A., Hoeltl, W., Horwich, A., Huddart, R., Jewett, M., Joffe, J., Jones, W. G., Kisbenedek, L., Klepp, O., Kliesch, S., Koehrmann, K. U., Kollmannsberger, C., Kuczyk, M., Laguna, P., Galvis, O. L., Loy, V., Mason, M. D., Mead, G. M., Mueller, R., Nichols, C., Nicolai, N., Oliver, T., Ondrus, D., Oosterhof, G. O. N., Ares, L. P., Pizzocaro, G., Pont, J., Pottek, T., Powles, T., Rick, O., Rosti, G., Salvioni, R., Scheiderbauer, J., Schmelz, H., Schmidberger, H., Schmoll, H., Schrader, M., Sedlmayer, F., Skakkebæk, Niels Erik, Sohaib, A., Tjulandin, S., Warde, P., Weinknecht, S., Weissbach, L., Wittekind, C., Winter, E., Wood, L. & von der Maase, H., 2007, In: European Urology. 53, 3, p. 478-496 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  75. Published

    High normal testosterone levels in infants with non-mosaic Klinefelter's syndrome

    Aksglaede, L., Petersen, Jørgen Holm, Main, Katharina Maria, Skakkebæk, Niels Erik & Juul, Anders, 2007, In: European Journal of Endocrinology. 157, 3, p. 345-50 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  76. Published

    Improved gene expression signature of testicular carcinoma in situ

    Almstrup, Kristian, Leffers, H., Lothe, R. A., Skakkebæk, Niels Erik, Sonne, Si Brask, Nielsen, J. E., Rajpert-De Meyts, E. & Skotheim, R. I., 2007, In: International Journal of Andrology. 30, 4, p. 292-303

    Research output: Contribution to journalJournal articleResearchpeer-review

  77. Published

    Preserved fertility in a non-mosaic Klinefelter patient with a mutation in the fibroblast growth factor receptor 3 gene: case report

    Juul, Anders, Aksglaede, L., Lund, Allan Meldgaard, Duno, M., Skakkebæk, Niels Erik & Rajpert-De Meyts, E., 2007, In: Human Reproduction. 22, 7, p. 1907-11 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  78. Published

    Reduced serum testosterone levels in infant boys conceived by intracytoplasmic sperm injection

    Mau Kai, C., Main, Katharina Maria, Andersen, A. N., Loft, A., Skakkebæk, Niels Erik & Juul, Anders, 2007, In: Journal of Clinical Endocrinology and Metabolism. 92, 7, p. 2598-603 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  79. Published

    Serum sex hormone-binding globulin levels in healthy children and girls with precocious puberty before and during gonadotropin-releasing hormone agonist treatment

    Sørensen, K., Andersson, A. M., Skakkebæk, Niels Erik & Juul, Anders, 2007, In: Journal of Clinical Endocrinology and Metabolism. 92, 8, p. 3189-96 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  80. Published

    Testicular cancer trends as 'whistle blowers' of testicular developmental problems in populations

    Skakkebæk, Niels Erik, Rajpert-De Meyts, E., Jørgensen, N., Main, Katharina Maria, Leffers, H., Andersson, A., Juul, Anders, Jensen, T. K. & Toppari, J., 2007, In: International Journal of Andrology. 30, 4, p. 198-204; discussion 204-5

    Research output: Contribution to journalReviewResearch

  81. Published

    Translational repression of E2F1 mRNA in carcinoma in situ and normal testis correlates with expression of the miR-17-92 cluster

    Novotny, G. W., Sonne, Si Brask, Nielsen, J. E., Jonstrup, S. P., Hansen, M. A., Skakkebæk, Niels Erik, Rajpert-De Meyts, E., Kjems, J. & Leffers, H., 2007, In: Cell Death and Differentiation. 14, 4, p. 879-82 3 p.

    Research output: Contribution to journalLetterResearch

  82. 2006
  83. Published

    Identification and expression profiling of 10 novel spermatid expressed CYPT genes

    Hansen, M. A., Nielsen, J. E., Tanaka, M., Almstrup, Kristian, Skakkebæk, Niels Erik & Leffers, H., May 2006, In: Molecular Reproduction and Development. 73, 5, p. 568-579 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  84. Published

    Increased expression of alpha- and beta-globin mRNAs at the pituitary following exposure to estrogen during the critical period of neonatal sex differentiation in the rat

    Leffers, H., Navarro, V. M., Nielsen, J. E., Mayen, A., Pinilla, L., Dalgaard, M., Malagon, M. M., Castaño, J. P., Skakkebæk, Niels Erik, Aguilar, E. & Tena-Sempere, M., 1 Apr 2006, In: Journal of Steroid Biochemistry and Molecular Biology. 99, 1, p. 33-43 11 p.

    Research output: Contribution to journalJournal articleResearch

  85. Published

    Testicular dysgenesis syndrome: possible role of endocrine disrupters

    Bay, K., Asklund, C., Skakkebæk, Niels Erik & Andersson, A., 1 Mar 2006, In: Best Practice & Research: Clinical Endocrinology & Metabolism. 20, 1, p. 77-90 14 p.

    Research output: Contribution to journalJournal articleResearch

  86. Published

    Is human fecundity declining?

    Skakkebæk, Niels Erik, Jørgensen, N., Main, Katharina Maria, Rajpert-De Meyts, E., Leffers, H., Andersson, A., Juul, Anders, Carlsen, E., Mortensen, G. K., Jensen, T. K. & Toppari, J., 1 Feb 2006, In: International Journal of Andrology. 29, 1, p. 2-11 10 p.

    Research output: Contribution to journalJournal articleResearch

  87. Published

    Serum levels of activin A and inhibin A are not related to the increased susceptibility to pre-eclampsia in type I diabetic pregnancies

    Ekbom, P., Damm, Peter, Andersson, A., Skakkebæk, Niels Erik, Feldt-Rasmussen, Ulla & Mathiesen, Elisabeth, 1 Jan 2006, In: Acta Obstetricia et Gynecologica Scandinavica. 85, 2, p. 143-7 5 p.

    Research output: Contribution to journalJournal articleResearch

  88. Published

    A prospective study of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-3 in 942 healthy infants: associations with birth weight, gender, growth velocity, and breastfeeding

    Chellakooty, M., Juul, A., Boisen, K. A., Damgaard, I. N., Kai, C. M., Schmidt, I. M., Petersen, Jørgen Holm, Skakkebæk, Niels Erik & Main, K. M., 2006, In: Journal of Clinical Endocrinology and Metabolism. 91, 3, p. 820-826 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  89. Published

    CDH1 (E-cadherin) in testicular germ cell neoplasia: suppressed translation of mRNA in pre-invasive carcinoma in situ but increased protein levels in advanced tumours

    Sonne, Si Brask, Hoei-Hansen, C. E., Nielsen, J. E., Herlihy, A. S., Andersson, A., Almstrup, Kristian, Daugaard, G., Skakkebæk, Niels Erik, Leffers, H., Rajpert-De Meyts, E., Sonne, S. B., Hoei-Hansen, C. E., Nielsen, J. E., Herlihy, A. S., Andersson, A., Almstrup, K., Daugaard, G., Skakkebæk, Niels Erik, Leffers, H. & Rajpert-De Meyts, E., 2006, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 114, 7-8, p. 549-58 10 p.

    Research output: Contribution to journalJournal articleResearch

  90. Published

    From embryonic stem cells to testicular germ cell cancer-- should we be concerned?

    Almstrup, Kristian, Sonne, Si Brask, Hoei-Hansen, C. E., Ottesen, A. M., Nielsen, J. E., Skakkebæk, Niels Erik, Leffers, H. & Rajpert-De Meyts, E., 2006, In: International Journal of Andrology. 29, 1, p. 211-8 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  91. Published

    Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age

    Main, Katharina Maria, Mortensen, G. K., Kaleva, M. M., Boisen, K. A., Damgaard, I. N., Chellakooty, M., Schmidt, I. M., Suomi, A., Virtanen, H. E., Petersen, J. H., Andersson, A., Toppari, J. & Skakkebæk, Niels Erik, 2006, In: Environmental Health Perspectives. 114, 2, p. 270-276 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  92. Published

    Identity of M2A (D2-40) antigen and gp36 (Aggrus, T1A-2, podoplanin) in human developing testis, testicular carcinoma in situ and germ-cell tumours

    Sonne, Si Brask, Herlihy, A. S., Hoei-Hansen, C. E., Nielsen, J. E., Almstrup, Kristian, Skakkebæk, Niels Erik, Marks, A., Leffers, H. & Rajpert-De Meyts, E., 2006, In: Virchows Archiv. 449, 2, p. 200-6 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  93. Published

    Natural history of seminiferous tubule degeneration in Klinefelter syndrome

    Aksglaede, L., Wikström, A. M., Rajpert-De Meyts, E., Dunkel, L., Skakkebæk, Niels Erik & Juul, Anders, 2006, In: Human Reproduction Update. 12, 1, p. 39-48 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  94. Published

    Pubertal development in Danish children: comparison of recent European and US data

    Juul, Anders, Teilmann, Grete Katrine, Scheike, T. H., Hertel, N., Holm, Kirsten, Laursen, E., Main, Katharina Maria & Skakkebæk, Niels Erik, 2006, In: International Journal of Andrology. 29, 1, p. 247-55; discussion 286-90

    Research output: Contribution to journalJournal articleResearchpeer-review

  95. Published

    The sensitivity of the child to sex steroids: possible impact of exogenous estrogens

    Aksglaede, L., Juul, Anders, Leffers, H., Skakkebæk, Niels Erik & Andersson, A., 2006, In: Human Reproduction Update. 12, 4, p. 341-9 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  96. 2005
  97. Published

    Genome-wide gene expression profiling of testicular carcinoma in situ progression into overt tumours

    Almstrup, Kristian, Høi-Hansen, Christina Engel, Nielsen, J. E., Wirkner, U., Ansorge, W., Skakkebæk, Niels Erik, Rajpert-De Meyts, E. & Leffers, H., 23 May 2005, In: British Journal of Cancer. 92, 10, p. 1934-1941 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  98. Published

    A subfertile patient diagnosed with testicular carcinoma in situ by immunocytological staining for AP-2γ in semen samples: Case report

    Høi-Hansen, Christina Engel, Rajpert-De Meyts, E., Carlsen, E., Almstrup, Kristian, Leffers, H. & Skakkebæk, Niels Erik, Mar 2005, In: Human Reproduction. 20, 3, p. 579-582 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  99. Published

    Behandling og udredning af mandlig infertilitet og hypogonadisme

    Carlsen, E., Jørgensen, N., Juul, Anders & Skakkebæk, Niels Erik, 2005, In: Maanedsskrift for Praktisk Laegegerning. 83, p. 1239-49 10 p.

    Research output: Contribution to journalReviewResearch

  100. Published

    Genomic and gene expression signature of the pre-invasive testicular carcinoma in situ

    Almstrup, Kristian, Ottesen, A. M., Sonne, Si Brask, Hoei-Hansen, C. E., Leffers, H., Rajpert-De Meyts, E. & Skakkebæk, Niels Erik, 2005, In: Cell and Tissue Research. 322, 1, p. 159-65 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  101. Published

    Insulin-like growth factor I (IGF-I) and IGF-binding protein 3 as diagnostic markers of growth hormone deficiency in infancy

    Jensen, R. B., Jeppesen, K. A., Vielwerth, S., Michaelsen, K. F., Main, Katharina Maria, Skakkebæk, Niels Erik & Juul, Anders, 2005, In: Hormone Research. 63, 1, p. 15-21 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  102. Published

    Prevalence and incidence of precocious pubertal development in Denmark: an epidemiologic study based on national registries

    Teilmann, Grete Katrine, Pedersen, C., Jensen, T. K., Skakkebæk, Niels Erik & Juul, Anders, 2005, In: Pediatrics. 116, 6, p. 1323-8 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  103. Published

    Stem cell pluripotency factor NANOG is expressed in human fetal gonocytes, testicular carcinoma in situ and germ cell tumours

    Hoei-Hansen, C. E., Almstrup, Kristian, Nielsen, J. E., Sonne, Si Brask, Graem, N., Skakkebæk, Niels Erik, Leffers, H. & Rajpert-De Meyts, E., 2005, In: Histopathology. 47, 1, p. 48-56 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  104. 2004
  105. Published

    Embryonic stem cell-like features of testicular carcinoma in situ revealed by genome-wide gene expression profiling

    Almstrup, Kristian, Høi-Hansen, Christina Engel, Wirkner, U., Blake, J., Schwager, C., Ansorge, W., Nielsen, J. E., Skakkebæk, Niels Erik, Rajpert-De Meyts, E. & Leffers, H., 15 Jul 2004, In: Cancer Research. 64, 14, p. 4736-4743 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  106. Published

    Analysis of cell-type-specific gene expression during mouse spermatogenesis

    Almstrup, Kristian, Nielsen, J. E., Hansen, M. A., Tanaka, M., Skakkebæk, Niels Erik & Leffers, H., Jun 2004, In: Biology of Reproduction. 70, 6, p. 1751-1761 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  107. Published

    Identification of genes differentially expressed in testes containing carcinoma in situ

    Høi-Hansen, Christina Engel, Nielsen, J. E., Almstrup, Kristian, Hansen, M. A., Skakkebæk, Niels Erik, Rajpert-DeMeyts, E. & Leffers, H., Jun 2004, In: Molecular Human Reproduction. 10, 6, p. 423-431 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  108. Published

    A longitudinal study of intrauterine growth and the placental growth hormone (GH)-insulin-like growth factor I axis in maternal circulation: association between placental GH and fetal growth

    Chellakooty, M., Vangsgaard, K., Larsen, T., Scheike, T., Falck-Larsen, J., Legarth, J., Andersson, A. M., Main, Katharina Maria, Skakkebæk, Niels Erik & Juul, Anders, 1 Jan 2004, In: Journal of Clinical Endocrinology and Metabolism. 89, 1, p. 384-91 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 35319116