A systematic review of the incidence and prevalence of cancer in multiple sclerosis
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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A systematic review of the incidence and prevalence of cancer in multiple sclerosis. / Marrie, Ruth Ann; Reider, Nadia; Cohen, Jeffrey; Stuve, Olaf; Trojano, Maria; Sorensen, Per Soelberg; Reingold, Stephen C; Cutter, Gary.
I: Multiple Sclerosis Journal, Bind 21, Nr. 3, 03.2015, s. 294-304.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - A systematic review of the incidence and prevalence of cancer in multiple sclerosis
AU - Marrie, Ruth Ann
AU - Reider, Nadia
AU - Cohen, Jeffrey
AU - Stuve, Olaf
AU - Trojano, Maria
AU - Sorensen, Per Soelberg
AU - Reingold, Stephen C
AU - Cutter, Gary
N1 - © The Author(s), 2014.
PY - 2015/3
Y1 - 2015/3
N2 - BACKGROUND: Studies of cancer incidence and prevalence in multiple sclerosis (MS) have produced conflicting results.OBJECTIVE: To estimate the incidence and prevalence of cancer in persons with MS and review the quality of included studies.METHODS: We searched the PUBMED, SCOPUS, Web of Knowledge, and EMBASE databases, conference proceedings, and reference lists of all articles retrieved. Abstracts were screened for relevance by two reviewers. Data from included articles were captured using a standardized form, and the abstraction was verified by a second reviewer. We assessed quality of the included studies. We quantitatively assessed studies using the I (2) statistic, and conducted meta-analyses for population-based studies.RESULTS: We identified 38 studies. Estimates for incidence and prevalence varied substantially for most cancers. In population-based studies, cervical, breast, and digestive cancers had the highest incidence. The risk of meningiomas and urinary system cancers appeared higher than expected, while the risks of pancreatic, ovarian, prostate and testicular cancer were lower than expected.CONCLUSION: The complexity of understanding cancer risk in MS is augmented by inconsistencies in study design, and the relative paucity of age, sex and ethnicity-specific risk estimates from which the strong impact of age on the incidence of cancers can be assessed.
AB - BACKGROUND: Studies of cancer incidence and prevalence in multiple sclerosis (MS) have produced conflicting results.OBJECTIVE: To estimate the incidence and prevalence of cancer in persons with MS and review the quality of included studies.METHODS: We searched the PUBMED, SCOPUS, Web of Knowledge, and EMBASE databases, conference proceedings, and reference lists of all articles retrieved. Abstracts were screened for relevance by two reviewers. Data from included articles were captured using a standardized form, and the abstraction was verified by a second reviewer. We assessed quality of the included studies. We quantitatively assessed studies using the I (2) statistic, and conducted meta-analyses for population-based studies.RESULTS: We identified 38 studies. Estimates for incidence and prevalence varied substantially for most cancers. In population-based studies, cervical, breast, and digestive cancers had the highest incidence. The risk of meningiomas and urinary system cancers appeared higher than expected, while the risks of pancreatic, ovarian, prostate and testicular cancer were lower than expected.CONCLUSION: The complexity of understanding cancer risk in MS is augmented by inconsistencies in study design, and the relative paucity of age, sex and ethnicity-specific risk estimates from which the strong impact of age on the incidence of cancers can be assessed.
U2 - 10.1177/1352458514564489
DO - 10.1177/1352458514564489
M3 - Review
C2 - 25533302
VL - 21
SP - 294
EP - 304
JO - Multiple Sclerosis Journal
JF - Multiple Sclerosis Journal
SN - 1352-4585
IS - 3
ER -
ID: 137380442