Acute Kidney Injury because of Implanted Tobramycin Pellets: A Case Report

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Acute Kidney Injury because of Implanted Tobramycin Pellets : A Case Report. / Windfeld-Mathiasen, Josefine; Horwitz, Henrik; Schwartz, Frederik.

I: JBJS Case Connector, Bind 13, Nr. 2, e22.00621, 2023.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Windfeld-Mathiasen, J, Horwitz, H & Schwartz, F 2023, 'Acute Kidney Injury because of Implanted Tobramycin Pellets: A Case Report', JBJS Case Connector, bind 13, nr. 2, e22.00621. https://doi.org/10.2106/JBJS.CC.22.00621

APA

Windfeld-Mathiasen, J., Horwitz, H., & Schwartz, F. (2023). Acute Kidney Injury because of Implanted Tobramycin Pellets: A Case Report. JBJS Case Connector, 13(2), [e22.00621]. https://doi.org/10.2106/JBJS.CC.22.00621

Vancouver

Windfeld-Mathiasen J, Horwitz H, Schwartz F. Acute Kidney Injury because of Implanted Tobramycin Pellets: A Case Report. JBJS Case Connector. 2023;13(2). e22.00621. https://doi.org/10.2106/JBJS.CC.22.00621

Author

Windfeld-Mathiasen, Josefine ; Horwitz, Henrik ; Schwartz, Frederik. / Acute Kidney Injury because of Implanted Tobramycin Pellets : A Case Report. I: JBJS Case Connector. 2023 ; Bind 13, Nr. 2.

Bibtex

@article{a09cbd0b41954b2383ce1e0973cf1564,
title = "Acute Kidney Injury because of Implanted Tobramycin Pellets: A Case Report",
abstract = "Case:A 50-year-old healthy man with normal kidney function underwent surgery for fracture-related infection. Unfortunately, the patient received 2.5 times the intended dose of tobramycin pellets in the medullary cavity and developed acute kidney failure. Given the intraosseous administration of tobramycin, the drug displayed an absorption-dependent pharmacokinetics and multiple treatments with hemodialysis were needed. However, the patient had a complete recovery, and the kidney function remained normal at the 2-year follow-up.Conclusion:Tobramycin pellets are nephrotoxic in supratherapeutic doses; however, it was reversible in this case. Owing to the intraosseous administration, multiple treatments with hemodialysis were required.",
keywords = "antibiotic pellets, fracture, hemodialysis, infection, kidney injury, male, osteomyelitis, Tobramycin",
author = "Josefine Windfeld-Mathiasen and Henrik Horwitz and Frederik Schwartz",
note = "Publisher Copyright: {\textcopyright} 2023 Lippincott Williams and Wilkins. All rights reserved.",
year = "2023",
doi = "10.2106/JBJS.CC.22.00621",
language = "English",
volume = "13",
journal = "JBJS Case Connector",
issn = "2160-3251",
publisher = "Lippincott, Williams & Wilkins",
number = "2",

}

RIS

TY - JOUR

T1 - Acute Kidney Injury because of Implanted Tobramycin Pellets

T2 - A Case Report

AU - Windfeld-Mathiasen, Josefine

AU - Horwitz, Henrik

AU - Schwartz, Frederik

N1 - Publisher Copyright: © 2023 Lippincott Williams and Wilkins. All rights reserved.

PY - 2023

Y1 - 2023

N2 - Case:A 50-year-old healthy man with normal kidney function underwent surgery for fracture-related infection. Unfortunately, the patient received 2.5 times the intended dose of tobramycin pellets in the medullary cavity and developed acute kidney failure. Given the intraosseous administration of tobramycin, the drug displayed an absorption-dependent pharmacokinetics and multiple treatments with hemodialysis were needed. However, the patient had a complete recovery, and the kidney function remained normal at the 2-year follow-up.Conclusion:Tobramycin pellets are nephrotoxic in supratherapeutic doses; however, it was reversible in this case. Owing to the intraosseous administration, multiple treatments with hemodialysis were required.

AB - Case:A 50-year-old healthy man with normal kidney function underwent surgery for fracture-related infection. Unfortunately, the patient received 2.5 times the intended dose of tobramycin pellets in the medullary cavity and developed acute kidney failure. Given the intraosseous administration of tobramycin, the drug displayed an absorption-dependent pharmacokinetics and multiple treatments with hemodialysis were needed. However, the patient had a complete recovery, and the kidney function remained normal at the 2-year follow-up.Conclusion:Tobramycin pellets are nephrotoxic in supratherapeutic doses; however, it was reversible in this case. Owing to the intraosseous administration, multiple treatments with hemodialysis were required.

KW - antibiotic pellets

KW - fracture

KW - hemodialysis

KW - infection

KW - kidney injury

KW - male

KW - osteomyelitis

KW - Tobramycin

U2 - 10.2106/JBJS.CC.22.00621

DO - 10.2106/JBJS.CC.22.00621

M3 - Journal article

C2 - 37026770

AN - SCOPUS:85152165599

VL - 13

JO - JBJS Case Connector

JF - JBJS Case Connector

SN - 2160-3251

IS - 2

M1 - e22.00621

ER -

ID: 343341531