Association of atopic dermatitis with depression, anxiety, and suicidal ideation in children and adults: A systematic review and meta-analysis
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
BACKGROUND: Atopic dermatitis (AD) has been associated with anxiety and depression, but the magnitude of the alleged association is unknown.
OBJECTIVE: To perform a systematic review and meta-analysis of the association between AD in children and adults and, respectively, depression, anxiety, and suicidal behavior.
METHODS: The medical databases PubMed, Embase, and PsychINFO were searched.
RESULTS: There was a significant association between adult AD and, respectively, depression (pooled odds ratio [OR], 2.19; 95% confidence interval [CI], 1.87-2.57) and anxiety (pooled OR, 2.19; 95% CI, 1.75-2.73). AD was also associated with depression in children (pooled OR, 1.27; 95% CI, 1.12-1.45); few data were available for anxiety. A positive association was found between AD in adults and adolescents and suicidal ideation (pooled OR, 4.32; 95% CI, 1.93-9.66). Only a few studies examined the risk of completed suicide, but the majority showed a positive association between completed suicide and AD.
LIMITATIONS: Included studies used different definitions of depression and anxiety, and few studies examined the severity of AD.
CONCLUSION: Depression, anxiety, and suicidal ideation should be considered by doctors when treating patients with AD. Because AD disease improvement appears to reduce these risks, this should be a priority.
Originalsprog | Engelsk |
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Tidsskrift | Journal of the American Academy of Dermatology |
Vol/bind | 79 |
Udgave nummer | 3 |
Sider (fra-til) | 448-456.e30 |
ISSN | 0190-9622 |
DOI | |
Status | Udgivet - 2018 |
ID: 217512894