Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes
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Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes. / Schmitt, Jochen; Schwarz, Kristin; Baurecht, Hansjörg; Hotze, Melanie; Fölster-Holst, Regina; Rodríguez, Elke; Lee, Young A E; Franke, Andre; Degenhardt, Frauke; Lieb, Wolfgang; Gieger, Christian; Kabesch, Michael; Nöthen, Markus M; Irvine, Alan D; McLean, W H Irwin; Deckert, Stefanie; Stephan, Victoria; Schwarz, Peter; Aringer, Martin; Novak, Natalija; Weidinger, Stephan.
I: The Journal of allergy and clinical immunology, Bind 137, Nr. 1, 01.2016, s. 130-136.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes
AU - Schmitt, Jochen
AU - Schwarz, Kristin
AU - Baurecht, Hansjörg
AU - Hotze, Melanie
AU - Fölster-Holst, Regina
AU - Rodríguez, Elke
AU - Lee, Young A E
AU - Franke, Andre
AU - Degenhardt, Frauke
AU - Lieb, Wolfgang
AU - Gieger, Christian
AU - Kabesch, Michael
AU - Nöthen, Markus M
AU - Irvine, Alan D
AU - McLean, W H Irwin
AU - Deckert, Stefanie
AU - Stephan, Victoria
AU - Schwarz, Peter
AU - Aringer, Martin
AU - Novak, Natalija
AU - Weidinger, Stephan
N1 - Copyright © 2015 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
PY - 2016/1
Y1 - 2016/1
N2 - BACKGROUND: Atopic dermatitis (AD) is characterized by epidermal barrier failure and immune-mediated inflammation. Evidence on AD as a potential risk factor for inflammatory comorbidities is scarce.OBJECTIVES: We sought to test the hypothesis that prevalent AD is a risk factor for incident rheumatoid arthritis (RA) and inflammatory bowel disease (IBD; Crohn disease [CD], ulcerative colitis [UC]) and is inversely related to type 1 diabetes (T1D) and to investigate established RA, IBD, and T1D susceptibility loci in AD.METHODS: This cohort study used data from German National Health Insurance beneficiaries aged 40 years or younger (n = 655,815) from 2005 through 2011. Prevalent AD in the period 2005 to 2006 was defined as primary exposure, and incident RA, IBD, and T1D in the period 2007 to 2011 were defined as primary outcomes. Risk ratios were calculated with generalized linear models. Established RA, IBD, and T1D loci were explored in high-density genotyping data from 2,425 cases with AD and 5,449 controls.RESULTS: Patients with AD (n = 49,847) were at increased risk for incident RA (risk ratio [RR], 1.72; 95% CI, 1.25-2.37) and/or IBD (CD: RR, 1.34; 95% CI, 1.11-1.61; UC: RR, 1.25; 95% CI, 1.03-1.53). After adjusting for health care utilization, there was a nominally significant inverse effect on T1D risk (RR, 0.72; 95% CI, 0.53-0.998). There was no disproportionate occurrence of known RA, CD, UC, or T1D risk alleles in AD.CONCLUSIONS: AD is a risk factor for the development of RA and IBD. This excess comorbidity cannot be attributed to major known IBD and RA genetic risk factors.
AB - BACKGROUND: Atopic dermatitis (AD) is characterized by epidermal barrier failure and immune-mediated inflammation. Evidence on AD as a potential risk factor for inflammatory comorbidities is scarce.OBJECTIVES: We sought to test the hypothesis that prevalent AD is a risk factor for incident rheumatoid arthritis (RA) and inflammatory bowel disease (IBD; Crohn disease [CD], ulcerative colitis [UC]) and is inversely related to type 1 diabetes (T1D) and to investigate established RA, IBD, and T1D susceptibility loci in AD.METHODS: This cohort study used data from German National Health Insurance beneficiaries aged 40 years or younger (n = 655,815) from 2005 through 2011. Prevalent AD in the period 2005 to 2006 was defined as primary exposure, and incident RA, IBD, and T1D in the period 2007 to 2011 were defined as primary outcomes. Risk ratios were calculated with generalized linear models. Established RA, IBD, and T1D loci were explored in high-density genotyping data from 2,425 cases with AD and 5,449 controls.RESULTS: Patients with AD (n = 49,847) were at increased risk for incident RA (risk ratio [RR], 1.72; 95% CI, 1.25-2.37) and/or IBD (CD: RR, 1.34; 95% CI, 1.11-1.61; UC: RR, 1.25; 95% CI, 1.03-1.53). After adjusting for health care utilization, there was a nominally significant inverse effect on T1D risk (RR, 0.72; 95% CI, 0.53-0.998). There was no disproportionate occurrence of known RA, CD, UC, or T1D risk alleles in AD.CONCLUSIONS: AD is a risk factor for the development of RA and IBD. This excess comorbidity cannot be attributed to major known IBD and RA genetic risk factors.
KW - Adolescent
KW - Adult
KW - Arthritis, Rheumatoid
KW - Child
KW - Child, Preschool
KW - Dermatitis, Atopic
KW - Diabetes Mellitus, Type 1
KW - Female
KW - Germany
KW - Humans
KW - Incidence
KW - Infant
KW - Infant, Newborn
KW - Inflammatory Bowel Diseases
KW - Male
KW - Odds Ratio
KW - Prevalence
KW - Risk Factors
KW - Young Adult
KW - Journal Article
KW - Research Support, N.I.H., Extramural
KW - Research Support, Non-U.S. Gov't
U2 - 10.1016/j.jaci.2015.06.029
DO - 10.1016/j.jaci.2015.06.029
M3 - Journal article
C2 - 26253344
VL - 137
SP - 130
EP - 136
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
SN - 0091-6749
IS - 1
ER -
ID: 178193694