Atrial Septal Defect: Larger Right Ventricular Dimensions and Atrial Volumes as Early as in the First Month After Birth — a Case–Control Study Including 716 Neonates
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Atrial Septal Defect : Larger Right Ventricular Dimensions and Atrial Volumes as Early as in the First Month After Birth — a Case–Control Study Including 716 Neonates. / Dehn, Anna Maria; Dannesbo, Sofie; Sellmer, Anna; Høffner, Line; Blixenkrone-Møller, Elisabeth; Sillesen, Anne-Sophie; Raja, Anna Axelsson; Vejlstrup, Niels; Iversen, Kasper; Bundgaard, Henning; Hjortdal, Vibeke.
I: Pediatric Cardiology, Bind 44, Nr. 7, 2023, s. 1578-1586.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Atrial Septal Defect
T2 - Larger Right Ventricular Dimensions and Atrial Volumes as Early as in the First Month After Birth — a Case–Control Study Including 716 Neonates
AU - Dehn, Anna Maria
AU - Dannesbo, Sofie
AU - Sellmer, Anna
AU - Høffner, Line
AU - Blixenkrone-Møller, Elisabeth
AU - Sillesen, Anne-Sophie
AU - Raja, Anna Axelsson
AU - Vejlstrup, Niels
AU - Iversen, Kasper
AU - Bundgaard, Henning
AU - Hjortdal, Vibeke
N1 - Publisher Copyright: © 2023, The Author(s).
PY - 2023
Y1 - 2023
N2 - Atrial septal defect (ASD) is characterized by a left-to-right shunt causing dilatation of the right atrium and right ventricle as well as pulmonary hyperperfusion. The detection of ASDs often occurs late in childhood or adulthood. Little is known about cardiac structure and function in neonates with ASD. We analyzed neonatal echocardiograms from the Copenhagen Baby Heart Study, a multicenter, population-based cohort study of 27,595 neonates. We included 716 neonates with secundum-type ASDs and matched them 1:1 on sex and age at examination with neonates without ASD from the same birth cohort. Neonates with an ASD (median age 11 days, 52% female) had larger right ventricular (RV) dimensions than matched controls (RV longitudinal dimension end-diastole: 27.7 mm vs. 26.7 mm, p < 0.001; RV basal dimension end-diastole: 14.9 mm vs. 13.8 mm, p < 0.001; and RV outflow tract diameter 13.6 mm vs. 12.4 mm, p < 0.001). Atrial volumes were larger in neonates with ASD compared to controls (right atrial end-systolic volume: 2.9 ml vs. 2.1 ml, p < 0.001; and left atrial end-systolic volume 2.0 ml vs. 1.8 ml, p < 0.001). Tricuspid annular plane systolic excursion was larger in neonates with ASD than in controls (10.2 mm vs. 9.6 mm, p < 0.001). Left ventricular dimensions and function did not differ between neonates with ASD and controls. In conclusion, ASDs were associated with altered cardiac dimensions already in the neonatal period, with larger right ventricular dimensions and larger atrial volumes at echocardiography within the first 30 days after birth. ClinicalTrials.gov Identifier: NCT02753348 (April 27, 2016).
AB - Atrial septal defect (ASD) is characterized by a left-to-right shunt causing dilatation of the right atrium and right ventricle as well as pulmonary hyperperfusion. The detection of ASDs often occurs late in childhood or adulthood. Little is known about cardiac structure and function in neonates with ASD. We analyzed neonatal echocardiograms from the Copenhagen Baby Heart Study, a multicenter, population-based cohort study of 27,595 neonates. We included 716 neonates with secundum-type ASDs and matched them 1:1 on sex and age at examination with neonates without ASD from the same birth cohort. Neonates with an ASD (median age 11 days, 52% female) had larger right ventricular (RV) dimensions than matched controls (RV longitudinal dimension end-diastole: 27.7 mm vs. 26.7 mm, p < 0.001; RV basal dimension end-diastole: 14.9 mm vs. 13.8 mm, p < 0.001; and RV outflow tract diameter 13.6 mm vs. 12.4 mm, p < 0.001). Atrial volumes were larger in neonates with ASD compared to controls (right atrial end-systolic volume: 2.9 ml vs. 2.1 ml, p < 0.001; and left atrial end-systolic volume 2.0 ml vs. 1.8 ml, p < 0.001). Tricuspid annular plane systolic excursion was larger in neonates with ASD than in controls (10.2 mm vs. 9.6 mm, p < 0.001). Left ventricular dimensions and function did not differ between neonates with ASD and controls. In conclusion, ASDs were associated with altered cardiac dimensions already in the neonatal period, with larger right ventricular dimensions and larger atrial volumes at echocardiography within the first 30 days after birth. ClinicalTrials.gov Identifier: NCT02753348 (April 27, 2016).
KW - Atrial Septal Defect
KW - Copenhagen Baby Heart Study
KW - Echocardiography
KW - Neonates
KW - Right ventricular dimensions
U2 - 10.1007/s00246-023-03211-z
DO - 10.1007/s00246-023-03211-z
M3 - Journal article
C2 - 37369832
AN - SCOPUS:85163319757
VL - 44
SP - 1578
EP - 1586
JO - Pediatric Cardiology
JF - Pediatric Cardiology
SN - 0172-0643
IS - 7
ER -
ID: 368807808