Brain aging differs with cognitive ability regardless of education

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  • Kristine B. Walhovd
  • Lars Nyberg
  • Ulman Lindenberger
  • Inge K. Amlien
  • Øystein Sørensen
  • Yunpeng Wang
  • Athanasia M. Mowinckel
  • Rogier A. Kievit
  • Klaus P. Ebmeier
  • David Bartrés-Faz
  • Simone Kühn
  • Boraxbekk, Carl-Johan Oskar
  • Paolo Ghisletta
  • Kathrine Skak Madsen
  • Willliam F.C. Baaré
  • Enikő Zsoldos
  • Fredrik Magnussen
  • Didac Vidal-Piñeiro
  • Brenda Penninx
  • Anders M. Fjell

Higher general cognitive ability (GCA) is associated with lower risk of neurodegenerative disorders, but neural mechanisms are unknown. GCA could be associated with more cortical tissue, from young age, i.e. brain reserve, or less cortical atrophy in adulthood, i.e. brain maintenance. Controlling for education, we investigated the relative association of GCA with reserve and maintenance of cortical volume, -area and -thickness through the adult lifespan, using multiple longitudinal cognitively healthy brain imaging cohorts (n = 3327, 7002 MRI scans, baseline age 20–88 years, followed-up for up to 11 years). There were widespread positive relationships between GCA and cortical characteristics (level-level associations). In select regions, higher baseline GCA was associated with less atrophy over time (level-change associations). Relationships remained when controlling for polygenic scores for both GCA and education. Our findings suggest that higher GCA is associated with cortical volumes by both brain reserve and -maintenance mechanisms through the adult lifespan.

OriginalsprogEngelsk
Artikelnummer13886
TidsskriftScientific Reports
Vol/bind12
ISSN2045-2322
DOI
StatusUdgivet - 2022

Bibliografisk note

Funding Information:
The Lifebrain project is funded by the EU Horizon 2020 Grant Agreement Number 732592 (Lifebrain). In addition, the different sub-studies are supported by different sources: LCBC: The European Research Council under grant agreements 283634, 725025 (to A.M.F.) and 313440 (to K.B.W.), as well as the Norwegian Research Council (to A.M.F., K.B.W.), The National Association for Public Health's dementia research program, Norway (to A.M.F). Betula: a scholar grant from the Knut and Alice Wallenberg (KAW) foundation to L.N. Barcelona: Partially supported by an ICREA Academia 2019 grant award; by the California Walnut Commission, Sacramento, California. BASE-II has been supported by the German Federal Ministry of Education and Research under Grant Numbers 16SV5537/ 16SV5837/ 16SV5538/ 16SV5536K /01UW0808/ 01UW0706/ 01GL1716A/ 01GL1716B, the European Research Council under grant agreement 677804 (to S.K.). The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) was supported by a programme grant from the UK Biotechnology and Biological Sciences Research Council (Grant Number BB/H008217/1) and by continued intramural funding from the UK Medical Research Council to the Cognition & Brain Sciences Unit in Cambridge. Part of the research was conducted using the UK Biobank resource under Application Number 32048.

Funding Information:
The Lifebrain project is funded by the EU Horizon 2020 Grant Agreement Number 732592 (Lifebrain). In addition, the different sub-studies are supported by different sources: LCBC: The European Research Council under grant agreements 283634, 725025 (to A.M.F.) and 313440 (to K.B.W.), as well as the Norwegian Research Council (to A.M.F., K.B.W.), The National Association for Public Health's dementia research program, Norway (to A.M.F). Betula: a scholar grant from the Knut and Alice Wallenberg (KAW) foundation to L.N. Barcelona: Partially supported by an ICREA Academia 2019 grant award; by the California Walnut Commission, Sacramento, California. BASE-II has been supported by the German Federal Ministry of Education and Research under Grant Numbers 16SV5537/ 16SV5837/ 16SV5538/ 16SV5536K /01UW0808/ 01UW0706/ 01GL1716A/ 01GL1716B, the European Research Council under grant agreement 677804 (to S.K.). The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) was supported by a programme grant from the UK Biotechnology and Biological Sciences Research Council (Grant Number BB/H008217/1) and by continued intramural funding from the UK Medical Research Council to the Cognition & Brain Sciences Unit in Cambridge. Part of the research was conducted using the UK Biobank resource under Application Number 32048.

Publisher Copyright:
© 2022, The Author(s).

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