TY - JOUR

T1 - Brief rapport

T2 - Perceptual aberration in patients at ultra-high risk for psychosis

AU - Clemmensen, Lars

AU - Kristensen, Tina Dam

AU - Wenneberg, Christina

AU - Rimvall, Martin Køster

AU - Nordentoft, Merete

AU - Glenthoej, Louise

PY - 2024

Y1 - 2024

N2 - BackgroundUltra-high risk (UHR) is considered a forerunner of psychosis, but most UHR individuals do not later convert, yet remain symptomatic, disabled and help-seeking. Thus, there is an increased recognition of the UHR phenotype as a syndrome in itself, rather than merely a risk syndrome. It is therefore essential to investigate outcomes other than transition to psychosis. For this purpose, perceptual aberration appears to be a distinct, as well as a stable and less state-specific vulnerability indicator. We aimed to investigate perceptual aberration and associations with functional, neuro and social cognitive risk factors in an UHR sample.MethodOne hundred and twenty UHR and 64 healthy controls were compared on levels of perceptual aberration using the perceptual aberration scale. We further investigated cross-sectional associations between perceptual aberration and CAARMS (as a measure of subthreshold psychotic symptoms) and functional, neuro and social cognitive risk factors within the UHR using Spearmans ρ.ResultsPerceptual aberration was significantly higher in UHR than in healthy controls and was associated with social functioning, executive functioning, and emotion recognition.ConclusionOur findings are consistent with a view of perceptual aberration as a stable vulnerability indicator that varies little with clinical state.

AB - BackgroundUltra-high risk (UHR) is considered a forerunner of psychosis, but most UHR individuals do not later convert, yet remain symptomatic, disabled and help-seeking. Thus, there is an increased recognition of the UHR phenotype as a syndrome in itself, rather than merely a risk syndrome. It is therefore essential to investigate outcomes other than transition to psychosis. For this purpose, perceptual aberration appears to be a distinct, as well as a stable and less state-specific vulnerability indicator. We aimed to investigate perceptual aberration and associations with functional, neuro and social cognitive risk factors in an UHR sample.MethodOne hundred and twenty UHR and 64 healthy controls were compared on levels of perceptual aberration using the perceptual aberration scale. We further investigated cross-sectional associations between perceptual aberration and CAARMS (as a measure of subthreshold psychotic symptoms) and functional, neuro and social cognitive risk factors within the UHR using Spearmans ρ.ResultsPerceptual aberration was significantly higher in UHR than in healthy controls and was associated with social functioning, executive functioning, and emotion recognition.ConclusionOur findings are consistent with a view of perceptual aberration as a stable vulnerability indicator that varies little with clinical state.

U2 - 10.1111/eip.13445

DO - 10.1111/eip.13445

M3 - Journal article

C2 - 37257880

VL - 18

SP - 63

EP - 68

JO - Early Intervention in Psychiatry

JF - Early Intervention in Psychiatry

SN - 1751-7885

IS - 1

ER -