Cancer incidence in blood transfusion recipients
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Cancer incidence in blood transfusion recipients. / Hjalgrim, Henrik; Edgren, Gustaf; Rostgaard, Klaus; Reilly, Marie; Tran, Trung Nam; Titlestad, Kjell Einar; Shanwell, Agneta; Jersild, Casper; Adami, Johanna; Wikman, Agneta; Gridley, Gloria; Wideroff, Louise; Nyrén, Olof; Melbye, Mads.
I: Journal of the National Cancer Institute, Bind 99, Nr. 24, 12.2007, s. 1864-1874.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Cancer incidence in blood transfusion recipients
AU - Hjalgrim, Henrik
AU - Edgren, Gustaf
AU - Rostgaard, Klaus
AU - Reilly, Marie
AU - Tran, Trung Nam
AU - Titlestad, Kjell Einar
AU - Shanwell, Agneta
AU - Jersild, Casper
AU - Adami, Johanna
AU - Wikman, Agneta
AU - Gridley, Gloria
AU - Wideroff, Louise
AU - Nyrén, Olof
AU - Melbye, Mads
PY - 2007/12
Y1 - 2007/12
N2 - Background: Blood transfusions may influence the recipients' cancer risks both through transmission of biologic agents and by modulation of the immune system. However, cancer occurrence in transfusion recipients remains poorly characterized. Methods: We used computerized files from Scandinavian blood banks to identify a cohort of 888843 cancer-free recipients transfused after 1968. The recipients were followed from first registered transfusion until the date of death, emigration, cancer diagnosis, or December 31, 2002, whichever came first. Relative risks were expressed as ratios of the observed to the expected numbers of cancers, that is, standardized incidence ratios (SIRs), using incidence rates for the general Danish and Swedish populations as a reference. All statistical tests were two-sided. Results: During 5652918 person-years of follow-up, 80990 cancers occurred in the transfusion recipients, corresponding to a SIR of 1.45 (95% confidence interval [CI] = 1.44 to 1.46). The SIR for cancer overall decreased from 5.36 (95% CI = 5.29 to 5.43) during the first 6 months after transfusion to 1.10 or less for follow-up periods more than 2 years after the transfusion. However, the standardized incidence ratios for cancers of the tongue, mouth, pharynx, esophagus, liver, and respiratory and urinary tracts and for squamous cell skin carcinoma remained elevated beyond 10 years after the transfusion. Conclusions: The marked increase in cancer risk shortly after a blood transfusion may reflect the presence of undiagnosed occult cancers with symptoms that necessitated the blood transfusion. The continued increased risk of tobacco- and alcohol-related cancers suggests that lifestyle and other risk factors related to conditions prompting transfusion rather than transfusion-related exposures per se are important to the observed cancer occurrence in the recipients.
AB - Background: Blood transfusions may influence the recipients' cancer risks both through transmission of biologic agents and by modulation of the immune system. However, cancer occurrence in transfusion recipients remains poorly characterized. Methods: We used computerized files from Scandinavian blood banks to identify a cohort of 888843 cancer-free recipients transfused after 1968. The recipients were followed from first registered transfusion until the date of death, emigration, cancer diagnosis, or December 31, 2002, whichever came first. Relative risks were expressed as ratios of the observed to the expected numbers of cancers, that is, standardized incidence ratios (SIRs), using incidence rates for the general Danish and Swedish populations as a reference. All statistical tests were two-sided. Results: During 5652918 person-years of follow-up, 80990 cancers occurred in the transfusion recipients, corresponding to a SIR of 1.45 (95% confidence interval [CI] = 1.44 to 1.46). The SIR for cancer overall decreased from 5.36 (95% CI = 5.29 to 5.43) during the first 6 months after transfusion to 1.10 or less for follow-up periods more than 2 years after the transfusion. However, the standardized incidence ratios for cancers of the tongue, mouth, pharynx, esophagus, liver, and respiratory and urinary tracts and for squamous cell skin carcinoma remained elevated beyond 10 years after the transfusion. Conclusions: The marked increase in cancer risk shortly after a blood transfusion may reflect the presence of undiagnosed occult cancers with symptoms that necessitated the blood transfusion. The continued increased risk of tobacco- and alcohol-related cancers suggests that lifestyle and other risk factors related to conditions prompting transfusion rather than transfusion-related exposures per se are important to the observed cancer occurrence in the recipients.
UR - http://www.scopus.com/inward/record.url?scp=38449114338&partnerID=8YFLogxK
U2 - 10.1093/jnci/djm248
DO - 10.1093/jnci/djm248
M3 - Journal article
C2 - 18073377
AN - SCOPUS:38449114338
VL - 99
SP - 1864
EP - 1874
JO - National Cancer Institute. Journal (Online)
JF - National Cancer Institute. Journal (Online)
SN - 1460-2105
IS - 24
ER -
ID: 259456232