Clinically stable disease is associated with a lower risk of both income loss and disability pension for patients with multiple sclerosis

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Clinically stable disease is associated with a lower risk of both income loss and disability pension for patients with multiple sclerosis. / Chalmer, Thor Ameri; Buron, Mathias; Illes, Zsolt; Papp, Viktoria; Theodorsdottir, Asta; Schäfer, Jakob; Hansen, Victoria; Asgari, Nasrin; Skejø, Pernille Bro; Jensen, Henrik Boye; Sørensen, Per Soelberg; Magyari, Melinda.

I: Journal of neurology, neurosurgery, and psychiatry, Bind 91, Nr. 1, 2020, s. 67-74.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Chalmer, TA, Buron, M, Illes, Z, Papp, V, Theodorsdottir, A, Schäfer, J, Hansen, V, Asgari, N, Skejø, PB, Jensen, HB, Sørensen, PS & Magyari, M 2020, 'Clinically stable disease is associated with a lower risk of both income loss and disability pension for patients with multiple sclerosis', Journal of neurology, neurosurgery, and psychiatry, bind 91, nr. 1, s. 67-74. https://doi.org/10.1136/jnnp-2019-321523

APA

Chalmer, T. A., Buron, M., Illes, Z., Papp, V., Theodorsdottir, A., Schäfer, J., Hansen, V., Asgari, N., Skejø, P. B., Jensen, H. B., Sørensen, P. S., & Magyari, M. (2020). Clinically stable disease is associated with a lower risk of both income loss and disability pension for patients with multiple sclerosis. Journal of neurology, neurosurgery, and psychiatry, 91(1), 67-74. https://doi.org/10.1136/jnnp-2019-321523

Vancouver

Chalmer TA, Buron M, Illes Z, Papp V, Theodorsdottir A, Schäfer J o.a. Clinically stable disease is associated with a lower risk of both income loss and disability pension for patients with multiple sclerosis. Journal of neurology, neurosurgery, and psychiatry. 2020;91(1):67-74. https://doi.org/10.1136/jnnp-2019-321523

Author

Chalmer, Thor Ameri ; Buron, Mathias ; Illes, Zsolt ; Papp, Viktoria ; Theodorsdottir, Asta ; Schäfer, Jakob ; Hansen, Victoria ; Asgari, Nasrin ; Skejø, Pernille Bro ; Jensen, Henrik Boye ; Sørensen, Per Soelberg ; Magyari, Melinda. / Clinically stable disease is associated with a lower risk of both income loss and disability pension for patients with multiple sclerosis. I: Journal of neurology, neurosurgery, and psychiatry. 2020 ; Bind 91, Nr. 1. s. 67-74.

Bibtex

@article{473ab51de7024c39b7c8444b15406115,
title = "Clinically stable disease is associated with a lower risk of both income loss and disability pension for patients with multiple sclerosis",
abstract = "OBJECTIVE: To assess the risk of losing income from salaries and risk disability pension for multiple sclerosis patients with a clinically stable disease course 3 years after the start of disease-modifying therapy (DMT).METHODS: Data from the Danish Multiple Sclerosis Registry were linked to other Danish nationwide population-based databases. We included patients who started treatment with a DMT between 2001 and 2014. Patients were categorised into a clinically stable group (No Evidence of Disease Activity (NEDA-2)) and a clinically active group (relapse activity or 6-month confirmed Expanded Disability Status Scale worsening). Outcomes were: (1) loss of regular income from salaries and (2) a transfer payment labelled as disability pension. We used a Cox proportional hazards model to estimate confounder-adjusted HRs, and absolute risks were plotted using cumulative incidence curves accounting for competing risks.RESULTS: We included 2406 patients for the income analyses and 3123 patients for the disability pension analysis. Median follow-up from index date was ~5 years in both analyses. The NEDA-2 group had a 26% reduced rate of losing income (HR 0.74; 95% CI 0.60 to 0.92). HRs were calculated for 5-year intervals in the disability pension analysis: year 0-5: a 57% reduced rate of disability pension for the NEDA-2 group (HR 0.43; 95% CI 0.33 to 0.55) and year 5-10: a 36% reduced rate (HR 0.64; 95% CI 0.40 to 1.01).CONCLUSION: Clinically stable disease course (NEDA-2) is associated with a reduced risk of losing income from salaries and a reduced risk of disability pension.",
keywords = "Adolescent, Adult, Databases, Factual, Denmark/epidemiology, Disability Evaluation, Disease Progression, Endpoint Determination, Female, Humans, Income, Male, Middle Aged, Multiple Sclerosis/economics, Pensions/statistics & numerical data, Recurrence, Registries, Risk Assessment, Salaries and Fringe Benefits, Young Adult",
author = "Chalmer, {Thor Ameri} and Mathias Buron and Zsolt Illes and Viktoria Papp and Asta Theodorsdottir and Jakob Sch{\"a}fer and Victoria Hansen and Nasrin Asgari and Skej{\o}, {Pernille Bro} and Jensen, {Henrik Boye} and S{\o}rensen, {Per Soelberg} and Melinda Magyari",
note = "{\textcopyright} Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.",
year = "2020",
doi = "10.1136/jnnp-2019-321523",
language = "English",
volume = "91",
pages = "67--74",
journal = "Journal of Neurology, Neurosurgery and Psychiatry",
issn = "0022-3050",
publisher = "B M J Group",
number = "1",

}

RIS

TY - JOUR

T1 - Clinically stable disease is associated with a lower risk of both income loss and disability pension for patients with multiple sclerosis

AU - Chalmer, Thor Ameri

AU - Buron, Mathias

AU - Illes, Zsolt

AU - Papp, Viktoria

AU - Theodorsdottir, Asta

AU - Schäfer, Jakob

AU - Hansen, Victoria

AU - Asgari, Nasrin

AU - Skejø, Pernille Bro

AU - Jensen, Henrik Boye

AU - Sørensen, Per Soelberg

AU - Magyari, Melinda

N1 - © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2020

Y1 - 2020

N2 - OBJECTIVE: To assess the risk of losing income from salaries and risk disability pension for multiple sclerosis patients with a clinically stable disease course 3 years after the start of disease-modifying therapy (DMT).METHODS: Data from the Danish Multiple Sclerosis Registry were linked to other Danish nationwide population-based databases. We included patients who started treatment with a DMT between 2001 and 2014. Patients were categorised into a clinically stable group (No Evidence of Disease Activity (NEDA-2)) and a clinically active group (relapse activity or 6-month confirmed Expanded Disability Status Scale worsening). Outcomes were: (1) loss of regular income from salaries and (2) a transfer payment labelled as disability pension. We used a Cox proportional hazards model to estimate confounder-adjusted HRs, and absolute risks were plotted using cumulative incidence curves accounting for competing risks.RESULTS: We included 2406 patients for the income analyses and 3123 patients for the disability pension analysis. Median follow-up from index date was ~5 years in both analyses. The NEDA-2 group had a 26% reduced rate of losing income (HR 0.74; 95% CI 0.60 to 0.92). HRs were calculated for 5-year intervals in the disability pension analysis: year 0-5: a 57% reduced rate of disability pension for the NEDA-2 group (HR 0.43; 95% CI 0.33 to 0.55) and year 5-10: a 36% reduced rate (HR 0.64; 95% CI 0.40 to 1.01).CONCLUSION: Clinically stable disease course (NEDA-2) is associated with a reduced risk of losing income from salaries and a reduced risk of disability pension.

AB - OBJECTIVE: To assess the risk of losing income from salaries and risk disability pension for multiple sclerosis patients with a clinically stable disease course 3 years after the start of disease-modifying therapy (DMT).METHODS: Data from the Danish Multiple Sclerosis Registry were linked to other Danish nationwide population-based databases. We included patients who started treatment with a DMT between 2001 and 2014. Patients were categorised into a clinically stable group (No Evidence of Disease Activity (NEDA-2)) and a clinically active group (relapse activity or 6-month confirmed Expanded Disability Status Scale worsening). Outcomes were: (1) loss of regular income from salaries and (2) a transfer payment labelled as disability pension. We used a Cox proportional hazards model to estimate confounder-adjusted HRs, and absolute risks were plotted using cumulative incidence curves accounting for competing risks.RESULTS: We included 2406 patients for the income analyses and 3123 patients for the disability pension analysis. Median follow-up from index date was ~5 years in both analyses. The NEDA-2 group had a 26% reduced rate of losing income (HR 0.74; 95% CI 0.60 to 0.92). HRs were calculated for 5-year intervals in the disability pension analysis: year 0-5: a 57% reduced rate of disability pension for the NEDA-2 group (HR 0.43; 95% CI 0.33 to 0.55) and year 5-10: a 36% reduced rate (HR 0.64; 95% CI 0.40 to 1.01).CONCLUSION: Clinically stable disease course (NEDA-2) is associated with a reduced risk of losing income from salaries and a reduced risk of disability pension.

KW - Adolescent

KW - Adult

KW - Databases, Factual

KW - Denmark/epidemiology

KW - Disability Evaluation

KW - Disease Progression

KW - Endpoint Determination

KW - Female

KW - Humans

KW - Income

KW - Male

KW - Middle Aged

KW - Multiple Sclerosis/economics

KW - Pensions/statistics & numerical data

KW - Recurrence

KW - Registries

KW - Risk Assessment

KW - Salaries and Fringe Benefits

KW - Young Adult

U2 - 10.1136/jnnp-2019-321523

DO - 10.1136/jnnp-2019-321523

M3 - Journal article

C2 - 31727727

VL - 91

SP - 67

EP - 74

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

SN - 0022-3050

IS - 1

ER -

ID: 260764163