Connectivity between Right Inferior Frontal Gyrus and Supplementary Motor Area Predicts After-Effects of Right Frontal Cathodal tDCS on Picture Naming Speed
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Connectivity between Right Inferior Frontal Gyrus and Supplementary Motor Area Predicts After-Effects of Right Frontal Cathodal tDCS on Picture Naming Speed. / Rosso, Charlotte; Valabregue, R; Arbizu, C; Ferrieux, S; Vargas, P; Humbert, F; Attal, Y; Messé, A; Zavanone, C; Meunier, S; Cohen, L; Delmaire, C; Thielscher, A; Herz, D M; Siebner, H R; Samson, Y; Lehéricy, S.
I: Brain Stimulation, Bind 7, Nr. 1, 2014, s. 122-129.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Connectivity between Right Inferior Frontal Gyrus and Supplementary Motor Area Predicts After-Effects of Right Frontal Cathodal tDCS on Picture Naming Speed
AU - Rosso, Charlotte
AU - Valabregue, R
AU - Arbizu, C
AU - Ferrieux, S
AU - Vargas, P
AU - Humbert, F
AU - Attal, Y
AU - Messé, A
AU - Zavanone, C
AU - Meunier, S
AU - Cohen, L
AU - Delmaire, C
AU - Thielscher, A
AU - Herz, D M
AU - Siebner, H R
AU - Samson, Y
AU - Lehéricy, S
N1 - Copyright © 2014 Elsevier Inc. All rights reserved.
PY - 2014
Y1 - 2014
N2 - BACKGROUND: Cathodal transcranial direct current stimulation (tDCS) of the right frontal cortex improves language abilities in post-stroke aphasic patients. Yet little is known about the effects of right frontal cathodal tDCS on normal language function.OBJECTIVE/HYPOTHESIS: To explore the cathodal tDCS effects of the right-hemispheric homologue of Broca's area on picture naming in healthy individuals. We hypothesized that cathodal tDCS improves picture naming and that this effect is determined by the anatomical and functional connectivity of the targeted region.METHODS: Cathodal and sham tDCS were applied to the right inferior frontal gyrus in 24 healthy subjects before a picture-naming task. All participants were studied with magnetic resonance imaging at pre-interventional baseline. Probabilistic tractography and dynamic causal modeling of functional brain activity during a word repetition task were applied to characterize anatomical and functional connectivity.RESULTS: Subjects named pictures faster after cathodal relative to sham tDCS. The accelerating effect of tDCS was explained by a reduced frequency of very slow responses. tDCS-induced acceleration of picture naming correlated with larger volumes of the tract connecting the right Broca's area and the supplementary motor area (SMA) and greater functional coupling from the right SMA to the right Broca's area.CONCLUSIONS: The results support the notion that the after-effects of tDCS on brain function are at least in part determined by the anatomical and functional connectivity of the targeted region.
AB - BACKGROUND: Cathodal transcranial direct current stimulation (tDCS) of the right frontal cortex improves language abilities in post-stroke aphasic patients. Yet little is known about the effects of right frontal cathodal tDCS on normal language function.OBJECTIVE/HYPOTHESIS: To explore the cathodal tDCS effects of the right-hemispheric homologue of Broca's area on picture naming in healthy individuals. We hypothesized that cathodal tDCS improves picture naming and that this effect is determined by the anatomical and functional connectivity of the targeted region.METHODS: Cathodal and sham tDCS were applied to the right inferior frontal gyrus in 24 healthy subjects before a picture-naming task. All participants were studied with magnetic resonance imaging at pre-interventional baseline. Probabilistic tractography and dynamic causal modeling of functional brain activity during a word repetition task were applied to characterize anatomical and functional connectivity.RESULTS: Subjects named pictures faster after cathodal relative to sham tDCS. The accelerating effect of tDCS was explained by a reduced frequency of very slow responses. tDCS-induced acceleration of picture naming correlated with larger volumes of the tract connecting the right Broca's area and the supplementary motor area (SMA) and greater functional coupling from the right SMA to the right Broca's area.CONCLUSIONS: The results support the notion that the after-effects of tDCS on brain function are at least in part determined by the anatomical and functional connectivity of the targeted region.
KW - Adult
KW - Aged
KW - Brain Mapping
KW - Cross-Over Studies
KW - Diffusion Tensor Imaging
KW - Electric Stimulation
KW - Electrodes
KW - Female
KW - Frontal Lobe
KW - Humans
KW - Image Processing, Computer-Assisted
KW - Language
KW - Male
KW - Middle Aged
KW - Motor Cortex
KW - Neural Pathways
KW - Young Adult
U2 - 10.1016/j.brs.2013.08.007
DO - 10.1016/j.brs.2013.08.007
M3 - Journal article
C2 - 24099835
VL - 7
SP - 122
EP - 129
JO - Brain Stimulation
JF - Brain Stimulation
SN - 1935-861X
IS - 1
ER -
ID: 138555825