C-reactive protein modifies lipoprotein(a)-related risk for coronary heart disease: the BiomarCaRE project
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C-reactive protein modifies lipoprotein(a)-related risk for coronary heart disease : the BiomarCaRE project. / Arnold, Natalie; Blaum, Christopher; Goßling, Alina; Brunner, Fabian J.; Bay, Benjamin; Ferrario, Marco M.; Brambilla, Paolo; Cesana, Giancarlo; Leoni, Valerio; Palmieri, Luigi; Donfrancesco, Chiara; Padró, Teresa; Andersson, Jonas; Jousilahti, Pekka; Ojeda, Francisco; Zeller, Tanja; Linneberg, Allan; Söderberg, Stefan; Iacoviello, Licia; Gianfagna, Francesco; Sans, Susana; Veronesi, Giovanni; Thorand, Barbara; Peters, Annette; Tunstall-Pedoe, Hugh; Kee, Frank; Salomaa, Veikko; Schnabel, Renate B.; Kuulasmaa, Kari; Blankenberg, Stefan; Koenig, Wolfgang; Waldeyer, Christoph; the BiomarCaRE investigators.
I: European Heart Journal, Bind 45, Nr. 12, 2024, s. 1043-1054.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - C-reactive protein modifies lipoprotein(a)-related risk for coronary heart disease
T2 - the BiomarCaRE project
AU - Arnold, Natalie
AU - Blaum, Christopher
AU - Goßling, Alina
AU - Brunner, Fabian J.
AU - Bay, Benjamin
AU - Ferrario, Marco M.
AU - Brambilla, Paolo
AU - Cesana, Giancarlo
AU - Leoni, Valerio
AU - Palmieri, Luigi
AU - Donfrancesco, Chiara
AU - Padró, Teresa
AU - Andersson, Jonas
AU - Jousilahti, Pekka
AU - Ojeda, Francisco
AU - Zeller, Tanja
AU - Linneberg, Allan
AU - Söderberg, Stefan
AU - Iacoviello, Licia
AU - Gianfagna, Francesco
AU - Sans, Susana
AU - Veronesi, Giovanni
AU - Thorand, Barbara
AU - Peters, Annette
AU - Tunstall-Pedoe, Hugh
AU - Kee, Frank
AU - Salomaa, Veikko
AU - Schnabel, Renate B.
AU - Kuulasmaa, Kari
AU - Blankenberg, Stefan
AU - Koenig, Wolfgang
AU - Waldeyer, Christoph
AU - the BiomarCaRE investigators
N1 - Publisher Copyright: © The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved.
PY - 2024
Y1 - 2024
N2 - Background and Aims Recent investigations have suggested an interdependence of lipoprotein(a) [Lp(a)]-related risk for cardiovascular disease with background inflammatory burden. The aim the present analysis was to investigate whether high-sensitive C-reactive protein (hsCRP) modulates the association between Lp(a) and coronary heart disease (CHD) in the general population. Methods Data from 71 678 participants from 8 European prospective population-based cohort studies were used (65 661 without/6017 with established CHD at baseline; median follow-up 9.8/13.8 years, respectively). Fine and Gray competing risk-adjusted models were calculated according to accompanying hsCRP concentration (<2 and ≥2 mg/L). Results Among CHD-free individuals, increased Lp(a) levels were associated with incident CHD irrespective of hsCRP concentration: fully adjusted sub-distribution hazard ratios [sHRs (95% confidence interval)] for the highest vs. lowest fifth of Lp(a) distribution were 1.45 (1.23-1.72) and 1.48 (1.23-1.78) for a hsCRP group of <2 and ≥2 mg/L, respectively, with no interaction found between these two biomarkers on CHD risk (Pinteraction = 0.82). In those with established CHD, similar associations were seen only among individuals with hsCRP ≥ 2 mg/L [1.34 (1.03-1.76)], whereas among participants with a hsCRP concentration <2 mg/L, there was no clear association between Lp(a) and future CHD events [1.29 (0.98-1.71)] (highest vs. lowest fifth, fully adjusted models; Pinteraction = 0.024). Conclusions While among CHD-free individuals Lp(a) was significantly associated with incident CHD regardless of hsCRP, in participants with CHD at baseline, Lp(a) was related to recurrent CHD events only in those with residual inflammatory risk. These findings might guide adequate selection of high-risk patients for forthcoming Lp(a)-targeting compounds.
AB - Background and Aims Recent investigations have suggested an interdependence of lipoprotein(a) [Lp(a)]-related risk for cardiovascular disease with background inflammatory burden. The aim the present analysis was to investigate whether high-sensitive C-reactive protein (hsCRP) modulates the association between Lp(a) and coronary heart disease (CHD) in the general population. Methods Data from 71 678 participants from 8 European prospective population-based cohort studies were used (65 661 without/6017 with established CHD at baseline; median follow-up 9.8/13.8 years, respectively). Fine and Gray competing risk-adjusted models were calculated according to accompanying hsCRP concentration (<2 and ≥2 mg/L). Results Among CHD-free individuals, increased Lp(a) levels were associated with incident CHD irrespective of hsCRP concentration: fully adjusted sub-distribution hazard ratios [sHRs (95% confidence interval)] for the highest vs. lowest fifth of Lp(a) distribution were 1.45 (1.23-1.72) and 1.48 (1.23-1.78) for a hsCRP group of <2 and ≥2 mg/L, respectively, with no interaction found between these two biomarkers on CHD risk (Pinteraction = 0.82). In those with established CHD, similar associations were seen only among individuals with hsCRP ≥ 2 mg/L [1.34 (1.03-1.76)], whereas among participants with a hsCRP concentration <2 mg/L, there was no clear association between Lp(a) and future CHD events [1.29 (0.98-1.71)] (highest vs. lowest fifth, fully adjusted models; Pinteraction = 0.024). Conclusions While among CHD-free individuals Lp(a) was significantly associated with incident CHD regardless of hsCRP, in participants with CHD at baseline, Lp(a) was related to recurrent CHD events only in those with residual inflammatory risk. These findings might guide adequate selection of high-risk patients for forthcoming Lp(a)-targeting compounds.
KW - Coronary heart disease
KW - Epidemiology
KW - General population
KW - High-sensitive C-reactive protein
KW - Lipoprotein(a)
U2 - 10.1093/eurheartj/ehad867
DO - 10.1093/eurheartj/ehad867
M3 - Journal article
C2 - 38240386
AN - SCOPUS:85189079840
VL - 45
SP - 1043
EP - 1054
JO - European Heart Journal
JF - European Heart Journal
SN - 0195-668X
IS - 12
ER -
ID: 388021700