DaPeCa-7: comparative assessment of fluorodeoxyglucose positron emission tomography/computed tomography (CT) and conventional diagnostic CT in diagnosis of lymph node metastases, distant metastases and incidental findings in patients with invasive penile cancer
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DaPeCa-7 : comparative assessment of fluorodeoxyglucose positron emission tomography/computed tomography (CT) and conventional diagnostic CT in diagnosis of lymph node metastases, distant metastases and incidental findings in patients with invasive penile cancer. / Jakobsen, Jakob Kristian; Frahm Nielsen, Tomas; Ipsen, Pia; Albrecht-Beste, Elisabeth; Cardoso Costa, Junia; Alslev, Louise; Predbjørn Krarup, Kim; Grønkær Toft, Birgitte; Høyer, Søren; Bouchelouche, Kirsten; Bjerggaard Jensen, Jørgen.
I: BJU International, Bind 127, Nr. 2, 2021, s. 254-262.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - DaPeCa-7
T2 - comparative assessment of fluorodeoxyglucose positron emission tomography/computed tomography (CT) and conventional diagnostic CT in diagnosis of lymph node metastases, distant metastases and incidental findings in patients with invasive penile cancer
AU - Jakobsen, Jakob Kristian
AU - Frahm Nielsen, Tomas
AU - Ipsen, Pia
AU - Albrecht-Beste, Elisabeth
AU - Cardoso Costa, Junia
AU - Alslev, Louise
AU - Predbjørn Krarup, Kim
AU - Grønkær Toft, Birgitte
AU - Høyer, Søren
AU - Bouchelouche, Kirsten
AU - Bjerggaard Jensen, Jørgen
N1 - Publisher Copyright: © 2020 BJU International
PY - 2021
Y1 - 2021
N2 - Objectives: To evaluate diagnostic accuracy of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) compared to contrast-enhanced CT in assessment of inguinal lymph node (ILN) metastases, distant metastases and synchronous cancers in patients with penile squamous cell carcinoma (pSCC). Patients and Methods: During a 4-year period, patients with pSCC were scheduled for FDG PET/CT prior to surgical treatment at two referral centres that manage all penile cancers in Denmark. The primary endpoint was diagnostic accuracy of FDG PET/CT and of CT alone with histopathology or Response Evaluation Criteria In Solid Tumors (RECIST) as reference. Results: We evaluated 171 patients for distant metastases and synchronous incident cancers and examined 286 groins in 143 patients for LN metastases by FDG PET/CT. Six groins disclosed false negatives. FDG PET/CT sensitivity was 85.4% per patient. In 135 patients (270 groins), CT images were evaluated separately and 22 groins disclosed false negatives. CT sensitivity was 47.5% per patient. FDG PET/CT detected pSCC distant metastases in seven patients. Distant metastases from other cancers were newly detected in three patients. In eight patients, an incidental synchronous cancer was detected. Seven out of the 18 distant malignancies detected depended on FDG PET information. Conclusion: This study underlines the increased diagnostic accuracy of FDG PET/CT compared to CT alone in the evaluation of ILN status. In patients with palpable LNs, the advantage of FDG PET/CT over CT is less pronounced. FDG PET/CT may play a role in penile cancer evaluation.
AB - Objectives: To evaluate diagnostic accuracy of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) compared to contrast-enhanced CT in assessment of inguinal lymph node (ILN) metastases, distant metastases and synchronous cancers in patients with penile squamous cell carcinoma (pSCC). Patients and Methods: During a 4-year period, patients with pSCC were scheduled for FDG PET/CT prior to surgical treatment at two referral centres that manage all penile cancers in Denmark. The primary endpoint was diagnostic accuracy of FDG PET/CT and of CT alone with histopathology or Response Evaluation Criteria In Solid Tumors (RECIST) as reference. Results: We evaluated 171 patients for distant metastases and synchronous incident cancers and examined 286 groins in 143 patients for LN metastases by FDG PET/CT. Six groins disclosed false negatives. FDG PET/CT sensitivity was 85.4% per patient. In 135 patients (270 groins), CT images were evaluated separately and 22 groins disclosed false negatives. CT sensitivity was 47.5% per patient. FDG PET/CT detected pSCC distant metastases in seven patients. Distant metastases from other cancers were newly detected in three patients. In eight patients, an incidental synchronous cancer was detected. Seven out of the 18 distant malignancies detected depended on FDG PET information. Conclusion: This study underlines the increased diagnostic accuracy of FDG PET/CT compared to CT alone in the evaluation of ILN status. In patients with palpable LNs, the advantage of FDG PET/CT over CT is less pronounced. FDG PET/CT may play a role in penile cancer evaluation.
KW - F-fluorodeoxyglucose positron emission tomography
KW - #PenileCancer
KW - #uroonc
KW - computed tomography
KW - diagnostic accuracy
KW - distant metastases
KW - lymph node metastases
KW - penile cancer
KW - synchronous cancer
U2 - 10.1111/bju.15206
DO - 10.1111/bju.15206
M3 - Journal article
C2 - 33448605
AN - SCOPUS:85090313043
VL - 127
SP - 254
EP - 262
JO - BJU International
JF - BJU International
SN - 1464-4096
IS - 2
ER -
ID: 302817573